Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway

Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under diabetic conditions are very limited. Clinical evidence establishes an endothelial protective effect of metformin, but the underlying mechanisms remain unclear. We aimed to investigate whether metformin exerts i...

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Bibliographic Details
Published in:	Autophagy Vol. 15; no. 5; pp. 843 - 870
Main Authors:	Niu, Chao, Chen, Zhiwei, Kim, Kyoung Tae, Sun, Jia, Xue, Mei, Chen, Gen, Li, Santie, Shen, Yingjie, Zhu, Zhongxin, Wang, Xu, Liang, Jiaojiao, Jiang, Chao, Cong, Weitao, Jin, Litai, Li, Xiaokun
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 04.05.2019
Subjects:	Angiogenesis Animals Autophagy - drug effects Autophagy - genetics BNIP3 Capillary Permeability - drug effects Capillary Permeability - genetics Cells, Cultured diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetic Angiopathies - metabolism Diabetic Angiopathies - pathology Diabetic Angiopathies - physiopathology Diabetic Angiopathies - prevention & control Down-Regulation - drug effects Down-Regulation - genetics endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Gene Expression Regulation - drug effects GLI1 Hedgehog Proteins - drug effects Hedgehog Proteins - genetics Hedgehog Proteins - metabolism HEK293 Cells Human Umbilical Vein Endothelial Cells Humans Hyperglycemia - complications Hyperglycemia - drug therapy Hyperglycemia - metabolism Hyperglycemia - physiopathology LC3 Metformin - pharmacology Metformin - therapeutic use Mice Mice, Inbred C57BL Mice, Transgenic Research Paper Retina - drug effects Retina - metabolism Retina - pathology Signal Transduction - drug effects Signal Transduction - genetics Angiogenesis diabetes mellitus GLI1 LC3 endothelial dysfunction BNIP3
ISSN:	1554-8627, 1554-8635, 1554-8635
Online Access:	Get full text
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