Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection

Two human monoclonal antibodies (MAbs) (2F5 and 4E10) against the human immunodeficiency virus type 1 (HIV-1) envelope g41 cluster II membrane proximal external region (MPER) broadly neutralize HIV-1 primary isolates. However, these antibody specificities are rare, are not induced by Env immunizatio...

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Vydáno v:	Journal of virology Ročník 82; číslo 1; s. 115
Hlavní autoři:	Alam, S Munir, Scearce, Richard M, Parks, Robert J, Plonk, Kelly, Plonk, Steven G, Sutherland, Laura L, Gorny, Miroslaw K, Zolla-Pazner, Susan, Vanleeuwen, Stacie, Moody, M Anthony, Xia, Shi-Mao, Montefiori, David C, Tomaras, Georgia D, Weinhold, Kent J, Karim, Salim Abdool, Hicks, Charles B, Liao, Hua-Xin, Robinson, James, Shaw, George M, Haynes, Barton F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2008
Témata:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Cross Reactions Epitopes - immunology HIV Antibodies - blood HIV Antibodies - immunology HIV Antibodies - metabolism HIV Envelope Protein gp41 - immunology HIV Infections - immunology HIV-1 - immunology Humans Kinetics Lipids - immunology Mice Neutralization Tests Protein Binding
ISSN:	1098-5514, 1098-5514
On-line přístup:	Zjistit podrobnosti o přístupu
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