The DNA methylation profile of activated human natural killer cells

Natural killer (NK) cells are now recognized to exhibit characteristics akin to cells of the adaptive immune system. The generation of adaptive memory is linked to epigenetic reprogramming including alterations in DNA methylation. The study herein found reproducible genome wide DNA methylation chang...

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Bibliographic Details
Published in:	Epigenetics Vol. 11; no. 5; pp. 363 - 380
Main Authors:	Wiencke, John. K., Butler, Rondi, Hsuang, George, Eliot, Melissa, Kim, Stephanie, Sepulveda, Manuel A., Siegel, Derick, Houseman, E. Andres, Kelsey, Karl T.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 03.05.2016
Subjects:	Adaptive Immunity - genetics B-Lymphocytes - immunology B-Lymphocytes - metabolism Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - immunology Blood Donors CpG Islands - genetics Differentially methylated regions digital PCR DNA - genetics DNA - immunology DNA methylation DNA Methylation - genetics DNA Methylation - immunology Epigenesis, Genetic - genetics Epigenesis, Genetic - immunology Genome-Wide Association Study Homeodomain Proteins - genetics Homeodomain Proteins - immunology Humans innate immunity Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - genetics NK cells NKp46 Promoter Regions, Genetic Research Paper DNA methylation NK cells Differentially methylated regions NKp46 digital PCR innate immunity
ISSN:	1559-2294, 1559-2308
Online Access:	Get full text
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