Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer

Pancreatic cancer presents with a dismal mortality rate and is in urgent need of methods for early detection with potential for timely intervention. All living cells, including cancer cells, generate exosomes. We previously discovered double stranded genomic DNA in exosomes derived from the circulat...

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Vydáno v:	Cancer biology & therapy Ročník 18; číslo 3; s. 158 - 165
Hlavní autoři:	Yang, Sujuan, Che, Sara P. Y., Kurywchak, Paul, Tavormina, Jena L., Gansmo, Liv B., Correa de Sampaio, Pedro, Tachezy, Michael, Bockhorn, Maximilian, Gebauer, Florian, Haltom, Amanda R., Melo, Sonia A., LeBleu, Valerie S., Kalluri, Raghu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 04.03.2017
Témata:	Case-Control Studies Cell Line, Tumor Circulating exosomal DNA digital PCR DNA - blood DNA - genetics DNA, Neoplasm - blood DNA, Neoplasm - genetics exosome Exosomes - genetics Humans KRAS liquid biopsy Mutation pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Polymerase Chain Reaction - methods Proto-Oncogene Proteins p21(ras) - genetics Research Paper TP53 Tumor Suppressor Protein p53 - genetics pancreatic cancer Circulating exosomal DNA digital PCR KRAS TP53 exosome liquid biopsy
ISSN:	1538-4047, 1555-8576, 1555-8576
On-line přístup:	Získat plný text
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