HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic...

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Vydáno v:Cell cycle (Georgetown, Tex.) Ročník 18; číslo 23; s. 3239 - 3250
Hlavní autoři: Lei, Rui, Li, Jian, Liu, Feng, Li, Weihan, Zhang, Shizhen, Wang, Yang, Chu, Xi, Xu, Jinghong
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Taylor & Francis 02.12.2019
Témata:
fibroblasts
HIF-1α
keloid
NF-κB
Research Paper
TGF-β/Smad
TLR4
TGF-β/Smad
keloid
NF-κB
fibroblasts
HIF-1α
TLR4
ISSN:1538-4101, 1551-4005, 1551-4005
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Shrnutí:A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic cellular and biological behaviors. In this study, we found that the expression level of HIF-1α in keloid tissue was significantly higher than that in the normal skin tissue. Hypoxia-induced HIF-1α expression significantly inhibited cellular apoptosis and promoted cellular proliferation in keloid fibroblasts but not in normal fibroblasts. Specifically, HIF-1α activated the TGF-β/Smad and TLR4/MyD88/NF-κB pathways, and the interaction of these two pathways may promote the development of keloids. Moreover, in vivo experiments showed that the inhibition of HIF-1α significantly reduced the growth of keloids.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1538-4101
1551-4005
1551-4005
DOI:10.1080/15384101.2019.1670508