HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic...

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Bibliographic Details

Published in:	Cell cycle (Georgetown, Tex.) Vol. 18; no. 23; pp. 3239 - 3250
Main Authors:	Lei, Rui, Li, Jian, Liu, Feng, Li, Weihan, Zhang, Shizhen, Wang, Yang, Chu, Xi, Xu, Jinghong
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02.12.2019
Subjects:	fibroblasts HIF-1α keloid NF-κB Research Paper TGF-β/Smad TLR4 TGF-β/Smad keloid NF-κB fibroblasts HIF-1α TLR4
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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