Development of a predictive algorithm for the efficacy of half-life extension strategies

[Display omitted] A challenge in development of peptide and protein therapeutics is rapid elimination from the body, necessitating frequent dosing that may lead to toxicities and/or poor patient compliance. To solve this issue, there has been great investment into half-life extension of rapidly elim...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 660; p. 124382
Main Author:	Glassman, Patrick M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 20.07.2024
Subjects:	Algorithms Drug delivery Half-Life Half-life extension Humans Linear Models Models, Biological Multivariate regression Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacokinetics Multivariate regression Drug delivery Pharmacokinetics Half-life extension
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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