Polycomb silencers control cell fate, development and cancer

Key Points Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and progression of human cancer. Polycomb group (PcG) proteins regulate epigenetically mediated transcriptional silencing. They are involved in the ma...

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Bibliographic Details
Published in:	Nature reviews. Cancer Vol. 6; no. 11; pp. 846 - 856
Main Authors:	Sparmann, Anke, van Lohuizen, Maarten
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2006 Nature Publishing Group
Subjects:	Animals Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Gene mutations Gene Silencing Genetic aspects Health aspects Humans Identification and classification Neoplasms - genetics Neoplasms - pathology Neoplasms - physiopathology Polycomb-Group Proteins Prognosis Repressor Proteins - genetics Repressor Proteins - physiology review-article Tumor suppressor genes United States
ISSN:	1474-175X, 1474-1768
Online Access:	Get full text
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