Polycomb silencers control cell fate, development and cancer

Key Points Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and progression of human cancer. Polycomb group (PcG) proteins regulate epigenetically mediated transcriptional silencing. They are involved in the ma...

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Vydané v:	Nature reviews. Cancer Ročník 6; číslo 11; s. 846 - 856
Hlavní autori:	Sparmann, Anke, van Lohuizen, Maarten
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.11.2006 Nature Publishing Group
Predmet:	Animals Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Gene mutations Gene Silencing Genetic aspects Health aspects Humans Identification and classification Neoplasms - genetics Neoplasms - pathology Neoplasms - physiopathology Polycomb-Group Proteins Prognosis Repressor Proteins - genetics Repressor Proteins - physiology review-article Tumor suppressor genes United States
ISSN:	1474-175X, 1474-1768
On-line prístup:	Získať plný text
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Abstract	Key Points Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and progression of human cancer. Polycomb group (PcG) proteins regulate epigenetically mediated transcriptional silencing. They are involved in the maintenance of embryonic and adult stem cells and have been implicated in cancer development. PcG-mediated repression of key tumour-suppressor pathways, as well as their role in the regulation of stem cell maintenance might contribute to their oncogenic function. The recent global identification of PcG target genes provides the first insights into the mechanisms that govern stem cell maintenance and imply a dynamic regulation of PcG function during differentiation. Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. How do PcGs regulate cellular identity, and how might these functions be relevant during tumorigenesis? Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.
AbstractList	Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis. Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis. Key Points Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and progression of human cancer. Polycomb group (PcG) proteins regulate epigenetically mediated transcriptional silencing. They are involved in the maintenance of embryonic and adult stem cells and have been implicated in cancer development. PcG-mediated repression of key tumour-suppressor pathways, as well as their role in the regulation of stem cell maintenance might contribute to their oncogenic function. The recent global identification of PcG target genes provides the first insights into the mechanisms that govern stem cell maintenance and imply a dynamic regulation of PcG function during differentiation. Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. How do PcGs regulate cellular identity, and how might these functions be relevant during tumorigenesis? Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis.
Audience	Academic
Author	van Lohuizen, Maarten Sparmann, Anke
Author_xml	– sequence: 1 givenname: Anke surname: Sparmann fullname: Sparmann, Anke organization: Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121 – sequence: 2 givenname: Maarten surname: van Lohuizen fullname: van Lohuizen, Maarten email: m.v.lohuizen@nki.nl organization: Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17060944$$D View this record in MEDLINE/PubMed
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Snippet	Key Points Epigenetic gene silencing is an important mechanism for the loss of gene function and collaborates with genetic mutation in the initiation and... Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with...
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SubjectTerms	Animals Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Gene mutations Gene Silencing Genetic aspects Health aspects Humans Identification and classification Neoplasms - genetics Neoplasms - pathology Neoplasms - physiopathology Polycomb-Group Proteins Prognosis Repressor Proteins - genetics Repressor Proteins - physiology review-article Tumor suppressor genes
Title	Polycomb silencers control cell fate, development and cancer
URI	https://link.springer.com/article/10.1038/nrc1991 https://www.ncbi.nlm.nih.gov/pubmed/17060944 https://www.proquest.com/docview/275032076 https://www.proquest.com/docview/20526745 https://www.proquest.com/docview/68993265
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