The altering cellular components and function in tumor microenvironment during remissive and relapsed stages of anti-CD19 CAR T-cell treated lymphoma mice

Anti-CD19 chimeric antigen receptor (CAR) T cells represent a highly promising strategy for B-cell malignancies. Despite the inspiring initial achievement, remission in a notable fraction of subjects is short-lived, and relapse remains a major challenge. Tumor microenvironment (TME) was proved to be...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1101769
Main Authors:	Zhao, Kai, Ren, Chunxiao, Tang, Donghai, Zhao, Li, Chen, Xianxian, Wang, Ying, Xu, Kailin
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 25.01.2023
Subjects:	Animals CD19 chimeric antigen receptor T cell Immunology immunosuppression Immunotherapy, Adoptive lymphoma Lymphoma - therapy Lymphoma, B-Cell Mice Neoplasm Recurrence, Local Receptors, Chimeric Antigen Tumor Microenvironment immunosuppression chimeric antigen receptor T cell tumor microenvironment CD19 lymphoma
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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