Transcription factor TFII-I fine tunes innate properties of B lymphocytes

The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 14; p. 1067459
Main Authors:	Singh, Amit, Kaileh, Mary, De, Supriyo, Mazan-Mamczarz, Krystyna, Bayarsaihan, Dashzeveg, Sen, Ranjan, Roy, Ananda L.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 23.01.2023
Subjects:	Animals B cell Chromatin chromatin accessibility FO and MZ B cells Gtf2i Humans Immunology innate and adaptive immunity Mice Protein Binding Sjogren's Syndrome Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors, TFII - genetics Transcription Factors, TFII - metabolism Transcription Factors, TFIII - genetics Transcription Factors, TFIII - metabolism B cell FO and MZ B cells innate and adaptive immunity Gtf2i chromatin accessibility
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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