Transcription factor TFII-I fine tunes innate properties of B lymphocytes

The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here...

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Published in:Frontiers in immunology Vol. 14; p. 1067459
Main Authors: Singh, Amit, Kaileh, Mary, De, Supriyo, Mazan-Mamczarz, Krystyna, Bayarsaihan, Dashzeveg, Sen, Ranjan, Roy, Ananda L.
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 23.01.2023
Subjects:
Animals
B cell
Chromatin
chromatin accessibility
FO and MZ B cells
Gtf2i
Humans
Immunology
innate and adaptive immunity
Mice
Protein Binding
Sjogren's Syndrome
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription Factors, TFII - genetics
Transcription Factors, TFII - metabolism
Transcription Factors, TFIII - genetics
Transcription Factors, TFIII - metabolism
B cell
FO and MZ B cells
innate and adaptive immunity
Gtf2i
chromatin accessibility
ISSN:1664-3224, 1664-3224
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Abstract The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans.
AbstractList The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans.
The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans.
The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren's syndrome and Lupus in humans and, germline deletion of the gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for polymorphisms associated with B cell dominated autoimmune diseases in humans.
The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren's syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans.The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren's syndrome and Lupus in humans and, germline deletion of the Gtf2i gene in mice leads to embryonic lethality. Here we report a unique role for TFII-I in homeostasis of innate properties of B lymphocytes. Loss of Gtf2i in murine B lineage cells leads to an alteration in transcriptome, chromatin landscape and associated transcription factor binding sites, which exhibits myeloid-like features and coincides with enhanced sensitivity to LPS induced gene expression. TFII-I deficient B cells also show increased switching to IgG3, a phenotype associated with inflammation. These results demonstrate a role for TFII-I in maintaining immune homeostasis and provide clues for GTF2I polymorphisms associated with B cell dominated autoimmune diseases in humans.
Author Singh, Amit
Sen, Ranjan
Bayarsaihan, Dashzeveg
Roy, Ananda L.
Mazan-Mamczarz, Krystyna
Kaileh, Mary
De, Supriyo
AuthorAffiliation 3 Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center , Farmington, CT , United States
1 Laboratory of Molecular Biology and Immunology, National Institutes of Health, National Institute on Aging , Baltimore, MD , United States
2 Laboratory of Genetics & Genomics, National Institutes of Health, National Institute on Aging , Baltimore, MD , United States
AuthorAffiliation_xml – name: 3 Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health Center , Farmington, CT , United States
– name: 1 Laboratory of Molecular Biology and Immunology, National Institutes of Health, National Institute on Aging , Baltimore, MD , United States
– name: 2 Laboratory of Genetics & Genomics, National Institutes of Health, National Institute on Aging , Baltimore, MD , United States
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  givenname: Mary
  surname: Kaileh
  fullname: Kaileh, Mary
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  givenname: Supriyo
  surname: De
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Cites_doi 10.1038/s41418-020-0502-7
10.1016/j.immuni.2021.08.018
10.1242/dev.051052
10.1101/gad.11.19.2482
10.1038/ni.1666
10.1016/j.it.2019.01.005
10.1038/nature07765
10.1016/j.molcel.2010.05.004
10.1038/ng.2779
10.1146/annurev.immunol.23.021704.115728
10.1038/ncomms11889
10.1038/ng.3016
10.1038/nri3383
10.1038/ni.2262
10.1038/nn.4276
10.1038/nri2656
10.1128/MCB.00247-13
10.1002/eji.1830270707
10.1016/j.molcel.2011.04.011
10.1073/pnas.0811531106
10.1073/pnas.94.2.604
10.1002/dvg.22948
10.1007/s12026-008-8055-8
10.1016/j.dnarep.2021.103175
10.3389/fimmu.2021.655590
10.1186/s13059-021-02466-0
10.1126/science.aau0730
10.1038/354245a0
10.1038/srep27563
10.1016/j.gene.2011.10.030
10.1016/j.coi.2008.03.014
10.1038/nri3300
10.1111/j.1365-2141.2006.06360.x
10.1097/MD.0000000000000387
10.3389/fimmu.2021.711633
10.4049/jimmunol.180.3.1719
10.1084/jem.20152002
10.1073/pnas.1416674112
10.1016/j.molcel.2006.09.005
10.1038/s41576-018-0089-8
10.1038/nmeth.2688
10.1128/MCB.19.7.5014
10.1016/j.molmed.2017.04.002
10.4049/jimmunol.1501326
10.4049/jimmunol.1502163
10.1038/ni.2370
10.1371/journal.pgen.1010235
10.1002/ajmg.a.20496
10.1038/ni1008-1091
10.1038/emboj.2009.20
10.3389/fgene.2018.00368
10.1016/0092-8674(92)90293-L
10.1016/j.cell.2018.12.036
10.1038/s41572-021-00276-z
10.1093/hmg/7.3.325
10.1038/ni.3724
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Keywords B cell
FO and MZ B cells
innate and adaptive immunity
Gtf2i
chromatin accessibility
Language English
License Copyright © 2023 Singh, Kaileh, De, Mazan-Mamczarz, Bayarsaihan, Sen and Roy.
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Edited by: Hermann Eibel, University of Freiburg Medical Center, Germany
Reviewed by: Reuben Matthew Tooze, University of Leeds, United Kingdom; Stephen Nutt, The University of Melbourne, Australia
These authors share first authorship
This article was submitted to B Cell Biology, a section of the journal Frontiers in Immunology
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References Roy (B1) 1991; 354
Klemm (B43) 2019; 20
Stark (B47) 2011
Ren (B18) 2011; 42
Newman (B28) 2017; 18
Miller (B31) 2012; 13
Malhotra (B34) 2012; 13
Wibisana (B54) 2022; 18
Petrini (B14) 2014; 46
Yang (B17) 1997; 94
Cerutti (B23) 2013; 13
Schmidt (B19) 2009; 28
Allman (B20) 2008; 20
Kim (B12) 2016; 6
Hakre (B6) 2006; 24
Krzyzak (B50) 2016; 196
Wohner (B45) 2016; 213
Stadanlick (B25) 2008; 9
Buenrostro (B40) 2013; 10
Fernando (B39) 2021; 12
Makita (B29) 2021; 12
Yoshida (B36) 2019; 176
Enkhmandakh (B16) 2009; 106
Cao (B53) 2018; 361
Barak (B10) 2016; 19
Robles (B52) 2016; 7
Perez Jurado (B8) 1998; 7
Poitras (B51) 2010; 137
Roy (B4) 2021; 106
Novina (B26) 1999; 19
Wang (B44) 2009; 43
Benoist (B58) 2012; 12
Missen (B35) 2006; 135
Xu (B41) 2021; 22
Kim (B13) 2020; 27
Mohammad (B27) 2013; 33
Grueneberg (B2) 1997; 11
Pillai (B22) 2005; 23
Roy (B3) 2017; 23
Sladowski (B33) 2006; 44
Roy (B5) 2012; 492
Pena-Hernandez (B42) 2015; 112
Kimura (B57) 2018; 9
Enkhmandakh (B24) 2016; 54
Jager (B32) 2016; 196
Damelang (B55) 2019; 40
Zhang (B56) 2015; 94
Kitamura (B37) 1992; 69
Morris (B7) 2003
Kozel (B9) 2021; 7
Luecke (B49) 2021; 54
Pridans (B38) 2008; 180
Guery (B48) 1997; 27
Heinz (B46) 2010; 38
Li (B11) 2013; 45
Mammoto (B15) 2009; 457
Heng (B30) 2008; 9
Pillai (B21) 2009; 9
References_xml – volume: 27
  year: 2020
  ident: B13
  article-title: Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-020-0502-7
– volume: 54
  year: 2021
  ident: B49
  article-title: Stimulus-specific responses in innate immunity: Multilayered regulatory circuits
  publication-title: Immunity
  doi: 10.1016/j.immuni.2021.08.018
– volume: 137
  year: 2010
  ident: B51
  article-title: An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
  publication-title: Development
  doi: 10.1242/dev.051052
– volume: 11
  year: 1997
  ident: B2
  article-title: A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I
  publication-title: Genes Dev
  doi: 10.1101/gad.11.19.2482
– volume: 9
  year: 2008
  ident: B25
  article-title: Tonic b cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling
  publication-title: Nat Immunol
  doi: 10.1038/ni.1666
– volume: 40
  start-page: 197
  year: 2019
  ident: B55
  article-title: Role of IgG3 in infectious diseases
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2019.01.005
– volume: 457
  year: 2009
  ident: B15
  article-title: A mechanosensitive transcriptional mechanism that controls angiogenesis
  publication-title: Nature
  doi: 10.1038/nature07765
– volume: 38
  year: 2010
  ident: B46
  article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and b cell identities
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2010.05.004
– volume: 45
  year: 2013
  ident: B11
  article-title: A genome-wide association study in han Chinese identifies a susceptibility locus for primary sjogren's syndrome at 7q11.23
  publication-title: Nat Genet
  doi: 10.1038/ng.2779
– volume: 23
  year: 2005
  ident: B22
  article-title: Marginal zone b cells
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev.immunol.23.021704.115728
– volume: 7
  start-page: 11889
  year: 2016
  ident: B52
  article-title: Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating b-cell receptor signalling and shaping lymphocyte dynamics
  publication-title: Nat Commun
  doi: 10.1038/ncomms11889
– volume: 46
  year: 2014
  ident: B14
  article-title: A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors
  publication-title: Nat Genet
  doi: 10.1038/ng.3016
– volume: 13
  year: 2013
  ident: B23
  article-title: Marginal zone b cells: virtues of innate-like antibody-producing lymphocytes
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3383
– volume: 13
  start-page: 499
  year: 2012
  ident: B34
  article-title: Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
  publication-title: Nat Immunol
  doi: 10.1038/ni.2262
– volume: 19
  year: 2016
  ident: B10
  article-title: Neurobiology of social behavior abnormalities in autism and williams syndrome
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4276
– volume: 9
  year: 2009
  ident: B21
  article-title: The follicular versus marginal zone b lymphocyte cell fate decision
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2656
– volume: 33
  year: 2013
  ident: B27
  article-title: Dual phosphorylation of btk by akt/protein kinase b provides docking for 14-3-3zeta, regulates shuttling, and attenuates both tonic and induced signaling in b cells
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00247-13
– volume: 27
  year: 1997
  ident: B48
  article-title: Normal b cells fail to secrete interleukin-12
  publication-title: Eur J Immunol
  doi: 10.1002/eji.1830270707
– volume: 42
  year: 2011
  ident: B18
  article-title: Direct interactions of OCA-b and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2011.04.011
– volume: 106
  year: 2009
  ident: B16
  article-title: Essential functions of the williams-beuren syndrome-associated TFII-I genes in embryonic development
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.0811531106
– volume: 94
  year: 1997
  ident: B17
  article-title: BAP-135, a target for bruton's tyrosine kinase in response to b cell receptor engagement
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.94.2.604
– volume: 54
  year: 2016
  ident: B24
  article-title: Generation of a mouse model for a conditional inactivation of Gtf2i allele
  publication-title: Genesis
  doi: 10.1002/dvg.22948
– volume: 43
  year: 2009
  ident: B44
  article-title: IRF8 regulates myeloid and b lymphoid lineage diversification
  publication-title: Immunol Res
  doi: 10.1007/s12026-008-8055-8
– volume: 106
  start-page: 103175
  year: 2021
  ident: B4
  article-title: Role of the multifunctional transcription factor TFII-I in DNA damage repair
  publication-title: DNA Repair (Amst)
  doi: 10.1016/j.dnarep.2021.103175
– volume: 12
  year: 2021
  ident: B39
  article-title: Multi-dimensional gene regulation in innate and adaptive lymphocytes: A view from regulomes
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.655590
– volume: 22
  start-page: 244
  year: 2021
  ident: B41
  article-title: Acute depletion of CTCF rewires genome-wide chromatin accessibility
  publication-title: Genome Biol
  doi: 10.1186/s13059-021-02466-0
– volume: 361
  year: 2018
  ident: B53
  article-title: Joint profiling of chromatin accessibility and gene expression in thousands of single cells
  publication-title: Science
  doi: 10.1126/science.aau0730
– volume: 354
  year: 1991
  ident: B1
  article-title: Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF
  publication-title: Nature
  doi: 10.1038/354245a0
– volume: 6
  start-page: 27563
  year: 2016
  ident: B12
  article-title: Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis
  publication-title: Sci Rep
  doi: 10.1038/srep27563
– volume: 492
  start-page: 32
  year: 2012
  ident: B5
  article-title: Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later
  publication-title: Gene
  doi: 10.1016/j.gene.2011.10.030
– volume: 20
  year: 2008
  ident: B20
  article-title: Peripheral b cell subsets
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2008.03.014
– volume: 12
  year: 2012
  ident: B58
  article-title: Consortium biology in immunology: the perspective from the immunological genome project
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3300
– volume: 135
  year: 2006
  ident: B35
  article-title: Stage specific gene expression of serpins and their cognate proteases during myeloid differentiation
  publication-title: Br J Haematol
  doi: 10.1111/j.1365-2141.2006.06360.x
– volume: 94
  year: 2015
  ident: B56
  article-title: Serum IgG subclasses in autoimmune diseases
  publication-title: Med (Baltimore)
  doi: 10.1097/MD.0000000000000387
– volume: 12
  year: 2021
  ident: B29
  article-title: Post-transcriptional regulation of immune responses and inflammatory diseases by RNA-binding ZFP36 family proteins
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.711633
– volume: 180
  year: 2008
  ident: B38
  article-title: Identification of Pax5 target genes in early b cell differentiation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.3.1719
– volume: 213
  year: 2016
  ident: B45
  article-title: Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center b cell and plasma cell development
  publication-title: J Exp Med
  doi: 10.1084/jem.20152002
– volume-title: DiffBind: differential binding analysis of ChIP-seq peak data. r package version
  year: 2011
  ident: B47
– volume: 112
  year: 2015
  ident: B42
  article-title: Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I
  publication-title: Proc Natl Acad Sci U.S.A.
  doi: 10.1073/pnas.1416674112
– volume: 24
  year: 2006
  ident: B6
  article-title: Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.09.005
– volume: 20
  year: 2019
  ident: B43
  article-title: Chromatin accessibility and the regulatory epigenome
  publication-title: Nat Rev Genet
  doi: 10.1038/s41576-018-0089-8
– volume: 10
  year: 2013
  ident: B40
  article-title: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2688
– volume: 19
  year: 1999
  ident: B26
  article-title: Regulation of nuclear localization and transcriptional activity of TFII-I by bruton's tyrosine kinase
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.19.7.5014
– volume: 44
  year: 2006
  ident: B33
  article-title: Expression of the membrane complement regulatory proteins (CD55 and CD59) in human thymus
  publication-title: Folia Histochem Cytobiol
– volume: 23
  year: 2017
  ident: B3
  article-title: Pathophysiology of TFII-I: Old guard wearing new hats
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2017.04.002
– volume: 196
  year: 2016
  ident: B32
  article-title: Dendritic cells regulate GPR34 through mitogenic signals and undergo apoptosis in its absence
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1501326
– volume: 196
  year: 2016
  ident: B50
  article-title: CD83 modulates b cell activation and germinal center responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1502163
– volume: 13
  year: 2012
  ident: B31
  article-title: Deciphering the transcriptional network of the dendritic cell lineage
  publication-title: Nat Immunol
  doi: 10.1038/ni.2370
– volume: 18
  year: 2022
  ident: B54
  article-title: Enhanced transcriptional heterogeneity mediated by NF-kappaB super-enhancers
  publication-title: PloS Genet
  doi: 10.1371/journal.pgen.1010235
– start-page: 45
  year: 2003
  ident: B7
  article-title: GTF2I hemizygosity implicated in mental retardation in williams syndrome: genotype-phenotype analysis of five families with deletions in the williams syndrome region
  publication-title: Am J Med Genet A
  doi: 10.1002/ajmg.a.20496
– volume: 9
  year: 2008
  ident: B30
  article-title: Immunological genome project c. the immunological genome project: networks of gene expression in immune cells
  publication-title: Nat Immunol
  doi: 10.1038/ni1008-1091
– volume: 28
  year: 2009
  ident: B19
  article-title: Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, bright
  publication-title: EMBO J
  doi: 10.1038/emboj.2009.20
– volume: 9
  year: 2018
  ident: B57
  article-title: Williams-beuren syndrome as a potential risk factor for burkitt lymphoma
  publication-title: Front Genet
  doi: 10.3389/fgene.2018.00368
– volume: 69
  year: 1992
  ident: B37
  article-title: A critical role of lambda 5 protein in b cell development
  publication-title: Cell
  doi: 10.1016/0092-8674(92)90293-L
– volume: 176
  start-page: 897
  year: 2019
  ident: B36
  article-title: The cis-regulatory atlas of the mouse immune system
  publication-title: Cell
  doi: 10.1016/j.cell.2018.12.036
– volume: 7
  start-page: 42
  year: 2021
  ident: B9
  article-title: Williams syndrome
  publication-title: Nat Rev Dis Primers
  doi: 10.1038/s41572-021-00276-z
– volume: 7
  year: 1998
  ident: B8
  article-title: A duplicated gene in the breakpoint regions of the 7q11.23 williams-beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/7.3.325
– volume: 18
  year: 2017
  ident: B28
  article-title: Maintenance of the marginal-zone b cell compartment specifically requires the RNA-binding protein ZFP36L1
  publication-title: Nat Immunol
  doi: 10.1038/ni.3724
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Snippet The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic roles in gene regulation. TFII-I associated polymorphisms...
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StartPage 1067459
SubjectTerms Animals
B cell
Chromatin
chromatin accessibility
FO and MZ B cells
Gtf2i
Humans
Immunology
innate and adaptive immunity
Mice
Protein Binding
Sjogren's Syndrome
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription Factors, TFII - genetics
Transcription Factors, TFII - metabolism
Transcription Factors, TFIII - genetics
Transcription Factors, TFIII - metabolism
Title Transcription factor TFII-I fine tunes innate properties of B lymphocytes
URI https://www.ncbi.nlm.nih.gov/pubmed/36756127
https://www.proquest.com/docview/2774897273
https://pubmed.ncbi.nlm.nih.gov/PMC9900109
https://doaj.org/article/e12b30c6e59b4bb0a08d25cb577b1e47
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