Evidence for Multiple Binding Modes in the Initial Contact Between SARS‐CoV‐2 Spike S1 Protein and Cell Surface Glycans

Infection of host cells by SARS‐CoV‐2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1‐RBD to undergo a conformational change into the ‘open’ conformation. These two ev...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 29; no. 1; pp. e202202599 - n/a
Main Authors:	Parafioriti, Michela, Ni, Minghong, Petitou, Maurice, Mycroft‐West, Courtney J., Rudd, Timothy R., Gandhi, Neha S., Ferro, Vito, Turnbull, Jeremy E., Lima, Marcelo A., Skidmore, Mark A., Fernig, David G., Yates, Edwin A., Bisio, Antonella, Guerrini, Marco, Elli, Stefano
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 02.01.2023 John Wiley and Sons Inc
Subjects:	ACE2 Angiotensin Angiotensin-converting enzyme 2 Binding Binding Sites Cell fusion Cell membranes Cell surface Chemistry COVID-19 Extracellular matrix Heparan sulfate Humans Magnetic resonance spectroscopy MD simulation Membrane fusion Molecular dynamics Molecular Dynamics Simulation NMR NMR spectroscopy Nuclear magnetic resonance Oligosaccharides Peptidyl-dipeptidase A Polysaccharides Protein Binding Protein Domains Protein S protein S spike Proteins SARS-CoV-2 SARS-CoV-2 - metabolism Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Tethering Viral diseases Viruses MD simulation SARS-CoV-2 heparan sulfate NMR spectroscopy protein S spike
ISSN:	0947-6539, 1521-3765, 1521-3765
Online Access:	Get full text
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