Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice

Volatile anesthetics inhibit presynaptic voltage-gated sodium channels to reduce neurotransmitter release, but their effects on excitatory neuron excitability by sodium current inhibition are unclear. The authors hypothesized that inhibition of transient and persistent neuronal sodium currents by th...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Anesthesiology (Philadelphia) Jg. 131; H. 1; S. 94
Hauptverfasser:	Zhao, Wenling, Zhang, Mingyue, Liu, Jin, Liang, Peng, Wang, Rurong, Hemmings, Hugh C, Zhou, Cheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2019
Schlagworte:	Action Potentials Anesthetics, Inhalation - pharmacology Animals Female Hippocampus - drug effects Isoflurane - pharmacology Male Mice Models, Animal Pyramidal Cells - drug effects Sodium Channels - drug effects
ISSN:	1528-1175, 1528-1175
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!