Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3‐Center‐2‐Component Reactions of Cyclic Ketoacids

We report the use of bifunctional starting materials (ketoacids) in a diastereoselective Passerini three‐center‐two‐component reaction. Study of the reaction scope revealed the required structural features for stereoselectivity in the isocyanide addition. In this system, an interesting isomerization...

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Bibliographic Details
Published in:	European journal of organic chemistry Vol. 2017; no. 9; pp. 1262 - 1271
Main Authors:	Cioc, Răzvan C., Estévez, Verónica, van der Niet, Daan J., Vande Velde, Christophe M. L., Turrini, Nikolaus G., Hall, Mélanie, Faber, Kurt, Ruijter, Eelco, Orru, Romano V. A.
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 03.03.2017 Wiley Subscription Services, Inc John Wiley and Sons Inc
Subjects:	Chemistry Chemistry, Organic Cyclization Diastereoselectivity Ketoacids Lactones Multicomponent reactions Physical Sciences Rearrangement Science & Technology Multicomponent reactions ACID Cyclization Ketoacids DIASTEREOSELECTIVE SYNTHESIS HETEROCYCLES ISOCYANIDES UGI-REACTION FACILE Diastereoselectivity Lactones Rearrangement
ISSN:	1434-193X, 1099-0690
Online Access:	Get full text
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