Precision Medicine in the Diagnosis and Management of Orthopedic Biofilm Infections

Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of int...

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Published in:Frontiers in medicine Vol. 7; p. 580671
Main Authors: Baldan, Rossella, Sendi, Parham
Format: Journal Article
Language:English
Published: Lausanne Frontiers Media SA 10.11.2020
Frontiers Media S.A
Subjects:
Antibiotics
Antimicrobial agents
Biofilms
Diagnostic tests
Genomes
Global health
Health care industry
implant-related infection
Infections
Medicine
Meta-analysis
metagenomic sequencing
Microorganisms
minimal biofilm eradication concentration
next-generation sequencing
Orthopedics
osteomyelitis
Pathogens
Patients
Precision medicine
Systematic review
Transplants & implants
United States > US
ISSN:2296-858X, 2296-858X
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Abstract Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.
AbstractList Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.
Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.
Author Baldan, Rossella
Sendi, Parham
AuthorAffiliation 3 Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel , Basel , Switzerland
4 Department of Orthopaedic and Trauma Surgery, University Hospital Basel , Basel , Switzerland
2 Centre for Musculoskeletal Infections, University Hospital Basel , Basel , Switzerland
1 Institute for Infectious Diseases, University of Bern , Bern , Switzerland
AuthorAffiliation_xml – name: 1 Institute for Infectious Diseases, University of Bern , Bern , Switzerland
– name: 2 Centre for Musculoskeletal Infections, University Hospital Basel , Basel , Switzerland
– name: 3 Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel , Basel , Switzerland
– name: 4 Department of Orthopaedic and Trauma Surgery, University Hospital Basel , Basel , Switzerland
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  surname: Baldan
  fullname: Baldan, Rossella
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  givenname: Parham
  surname: Sendi
  fullname: Sendi, Parham
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Copyright © 2020 Baldan and Sendi.
Copyright © 2020 Baldan and Sendi. 2020 Baldan and Sendi
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Snippet Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field...
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SubjectTerms Antibiotics
Antimicrobial agents
Biofilms
Diagnostic tests
Genomes
Global health
Health care industry
implant-related infection
Infections
Medicine
Meta-analysis
metagenomic sequencing
Microorganisms
minimal biofilm eradication concentration
next-generation sequencing
Orthopedics
osteomyelitis
Pathogens
Patients
Precision medicine
Systematic review
Transplants & implants
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