Precision Medicine in the Diagnosis and Management of Orthopedic Biofilm Infections
Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of int...
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| Vydáno v: | Frontiers in medicine Ročník 7; s. 580671 |
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| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Lausanne
Frontiers Media SA
10.11.2020
Frontiers Media S.A |
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| ISSN: | 2296-858X, 2296-858X |
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| Abstract | Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections. |
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| AbstractList | Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections.Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections. Orthopedic biofilm infections are difficult to treat and require a multidisciplinary approach to diagnostics and management. Recent advances in the field include methods to disrupt biofilm, sequencing tools, and antibiotic susceptibility tests for bacteria residing in biofilm. The observation of interclonal differences in biofilm properties of the causative microorganisms, together with considerations of comorbidities and polypharmacy in a growing aging population, calls for a personalized approach to treat these infections. In this article, we highlight aspects of precision medicine that may open new perspectives in the diagnosis and management of orthopedic biofilm infections. |
| Author | Baldan, Rossella Sendi, Parham |
| AuthorAffiliation | 3 Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel , Basel , Switzerland 4 Department of Orthopaedic and Trauma Surgery, University Hospital Basel , Basel , Switzerland 2 Centre for Musculoskeletal Infections, University Hospital Basel , Basel , Switzerland 1 Institute for Infectious Diseases, University of Bern , Bern , Switzerland |
| AuthorAffiliation_xml | – name: 1 Institute for Infectious Diseases, University of Bern , Bern , Switzerland – name: 2 Centre for Musculoskeletal Infections, University Hospital Basel , Basel , Switzerland – name: 3 Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel , Basel , Switzerland – name: 4 Department of Orthopaedic and Trauma Surgery, University Hospital Basel , Basel , Switzerland |
| Author_xml | – sequence: 1 givenname: Rossella surname: Baldan fullname: Baldan, Rossella – sequence: 2 givenname: Parham surname: Sendi fullname: Sendi, Parham |
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| Cites_doi | 10.1038/s41564-018-0349-6 10.1128/MMBR.00013-14 10.1302/0301-620X.100B2.BJJ-2017-0531.R2 10.1093/cid/ciy303 10.1111/j.1365-2958.2006.05190.x 10.1111/1469-0691.12020 10.1128/IAI.01014-13 10.1093/ofid/ofz130 10.1016/j.ijmm.2014.03.003 10.1016/j.diagmicrobio.2015.09.012 10.1371/journal.pone.0009216 10.5301/jabfm.5000210 10.5858/arpa.2016-0539-RA 10.1016/S0140-6736(04)16934-1 10.1128/mBio.00756-16 10.1111/apm.12951 10.1002/jor.24683 10.1111/1469-0691.12651 10.1038/s41598-018-31437-y 10.1128/JCM.01227-07 10.1007/s11999-008-0263-y 10.1056/NEJMoa1401268 10.1038/nrg.2017.88 10.1016/j.nano.2019.102039 10.1111/joim.12233 10.1128/JCM.01459-14 10.1302/2046-3758.97.BJR-2019-0325.R2 10.1016/j.mimet.2014.02.020 10.1128/JB.00619-17 10.1002/jor.24616 10.1016/j.jinf.2012.08.018 10.1111/1574-6968.12125 10.1016/S1473-3099(15)00062-6 10.3899/jrheum.170990 10.1128/JCM.00402-18 10.1093/hmg/ddi261 10.1016/j.amjmed.2015.09.006 10.1016/j.cmi.2016.10.022 10.1093/infdis/jix148 10.1016/j.diagmicrobio.2018.06.009 10.1056/NEJMoa1803396 10.1080/14787210.2017.1262257 10.1038/nprot.2010.71 10.1093/infdis/jiy341 10.1128/JCM.00006-10 10.1016/j.arth.2018.09.018 10.1128/JCM.01686-08 10.1016/j.ijid.2020.05.044 10.1097/MD.0000000000014547 10.1128/JCM.03117-13 10.1074/mcp.RA117.000461 10.1016/j.ijid.2020.07.039 10.1074/jbc.M114.553073 10.1093/jac/dkw447 10.1093/cid/cis966 10.1016/j.mimet.2016.02.016 10.1016/j.arth.2018.02.078 10.1086/596736 10.1056/NEJMoa061588 10.1016/j.ijid.2020.05.125 10.1093/jac/dkt180 10.1007/s00264-013-2038-7 10.1038/s41579-018-0019-y 10.1128/JCM.00170-11 10.2106/JBJS.17.00434 10.1371/journal.ppat.1000422 10.1016/j.arth.2019.02.044 10.1101/gr.238170.118 10.1128/IAI.00394-15 10.3389/fmed.2020.00053 10.1016/j.ijantimicag.2018.05.004 10.1186/s12575-019-0106-0 10.1016/j.jinf.2011.05.005 10.1128/JCM.00462-17 10.1016/j.diagmicrobio.2014.03.021 10.1002/ana.24499 10.1128/JCM.00335-13 10.1128/JCM.00834-12 10.1186/1756-0500-7-457 10.1128/JCM.01351-17 10.1016/j.ijid.2020.03.055 10.1186/s12879-020-04955-2 10.1128/IAI.00699-12 10.1038/s41576-019-0113-7 |
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| Copyright | 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020 Baldan and Sendi. Copyright © 2020 Baldan and Sendi. 2020 Baldan and Sendi |
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| References | Schon (B49) 2017; 23 Hong (B53) 2018; 92 Suda (B20) 2013; 37 Miller (B55) 2019; 29 Blauwkamp (B54) 2019; 4 Masters (B64) 2019; 21 Sendi (B87) 2019; 6 Larsen (B23) 2018; 56 Park (B66) 2012; 80 Thieme (B80) 2019; 21 Rinaudo (B72) 2010; 5 Buscetta (B67) 2014; 289 Bémer (B22) 2014; 52 Dramsi (B73) 2006; 60 Cazanave (B14) 2013; 51 Portillo (B13) 2012; 65 Thoendel (B26) 2018; 67 Fang (B30) 2020; 99 Bai (B4) 2019; 98 Pham (B47) 2020; 7 Stoesser (B36) 2013; 68 Castellanos (B59) 2014; 12 Sadee (B9) 2005; 14 Lebeaux (B75) 2014; 78 Gomez (B18) 2012; 50 Li (B42) 2016; 7 Tande (B6) 2016; 129 Li (B33) 2019; 34 Osmon (B1) 2013; 56 Abdel Karim (B57) 2019; 34 B39 Rak (B21) 2013; 343 Cai (B31) 2020; 96 Wang (B29) 2020; 95 Kiso (B48) 2004; 364 Schlaberg (B52) 2017; 215 Chiu (B43) 2019; 20 Redanz (B70) 2018; 200 Moser (B84) 2019; 127 Ghasemi (B8) 2016; 6 Vincent (B35) 2017; 138 Dastgheyb (B63) 2015; 83 Tarabichi (B24) 2018; 100 Dora (B16) 2008; 46 Ruppen (B83) 2017; 72 Tarabichi (B25) 2018 Saeed (B65) 2020 Kobayashi (B17) 2008; 466 Gordon (B37) 2014; 52 Schlaberg (B51) 2017; 141 Harrison (B85) 2010; 5 Trampuz (B10) 2007; 357 Mesrati (B61) 2018; 52 Walker (B40) 2015; 15 Sendi (B5) 2011; 63 Wilson (B41) 2015; 78 Huang (B32) 2020; 9 Tasse (B86) 2018; 8 (B50) 2016 Ivy (B27) 2018; 56 Street (B28) 2017; 55 Patras (B69) 2018; 218 Piper (B11) 2009; 47 Macià (B78) 2014; 20 Konto-Ghiorghi (B71) 2009; 5 Wang (B45) 2020; 20 Zimmerli (B3) 2014; 276 Parvizi (B56) 2018; 33 Marín (B19) 2012; 50 Levy (B34) 2012; 18 Arciola (B7) 2018; 16 Wilson (B44) 2019; 380 Holmberg (B81) 2016; 84 Wilson (B38) 2014; 370 Simen (B76) 2009; 199 Sommerfeld Ross (B58) 2014; 100 Gardy (B77) 2018; 19 Singh (B2) 2019; 46 Suriyanarayanan (B74) 2018; 17 Cardile (B82) 2014; 7 Schwarz (B62) 2020 Achermann (B12) 2010; 48 Wang (B46) 2020; 97 Malone (B79) 2017; 15 Post (B60) 2014; 304 Ryu (B15) 2014; 79 Jiang (B68) 2014; 82 |
| References_xml | – volume: 4 start-page: 663 year: 2019 ident: B54 article-title: Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease publication-title: Nat Microbiol. doi: 10.1038/s41564-018-0349-6 – volume: 78 start-page: 510 year: 2014 ident: B75 article-title: Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics publication-title: Microbiol Mol Biol Rev. doi: 10.1128/MMBR.00013-14 – start-page: 127 year: 2018 ident: B25 article-title: Can next generation sequencing play a role in detecting pathogens in synovial fluid? publication-title: Bone Joint J. doi: 10.1302/0301-620X.100B2.BJJ-2017-0531.R2 – volume: 67 start-page: 1333 year: 2018 ident: B26 article-title: Identification of prosthetic joint infection pathogens using a shotgun metagenomics approach publication-title: Clin Infect Dis. doi: 10.1093/cid/ciy303 – volume: 60 start-page: 1401 year: 2006 ident: B73 article-title: Assembly and role of pili in group B streptococci publication-title: Mol Microbiol. doi: 10.1111/j.1365-2958.2006.05190.x – volume: 18 start-page: 1168 year: 2012 ident: B34 article-title: The role of molecular diagnostics in implant-associated bone and joint infection publication-title: Clin Microbiol Infect. doi: 10.1111/1469-0691.12020 – volume: 82 start-page: 1007 year: 2014 ident: B68 article-title: BsaB, a novel adherence factor of group B Streptococcus publication-title: Infect Immun doi: 10.1128/IAI.01014-13 – volume: 6 start-page: ofz130 year: 2019 ident: B87 article-title: Cardiac implantable electronic device-related infection due to Granulicatella adiacens publication-title: Open Forum Infect Dis doi: 10.1093/ofid/ofz130 – volume: 304 start-page: 565 year: 2014 ident: B60 article-title: Phenotypic and genotypic characterisation of Staphylococcus aureus causing musculoskeletal infections publication-title: Int J Med Microbiol. doi: 10.1016/j.ijmm.2014.03.003 – volume: 84 start-page: 19 year: 2016 ident: B81 article-title: Mature biofilms of Enterococcus faecalis and Enterococcus faecium are highly resistant to antibiotics publication-title: Diagn Microbiol Infect Dis. doi: 10.1016/j.diagmicrobio.2015.09.012 – volume: 5 start-page: e9216 year: 2010 ident: B72 article-title: Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus publication-title: PLoS ONE. doi: 10.1371/journal.pone.0009216 – volume: 12 start-page: 141 year: 2014 ident: B59 article-title: Adherence of S. epidermidis on different metals. A comparative in vitro study publication-title: J Appl Biomater Funct Mater. doi: 10.5301/jabfm.5000210 – volume: 141 start-page: 776 year: 2017 ident: B51 article-title: Validation of metagenomic next-generation sequencing tests for universal pathogen detection publication-title: Arch Pathol Lab Med. doi: 10.5858/arpa.2016-0539-RA – volume: 364 start-page: 759 year: 2004 ident: B48 article-title: Resistant influenza A viruses in children treated with oseltamivir: descriptive study publication-title: Lancet. doi: 10.1016/S0140-6736(04)16934-1 – volume: 7 start-page: e00756 year: 2016 ident: B42 article-title: Penicillin-binding protein transpeptidase signatures for tracking and predicting beta-lactam resistance levels in Streptococcus pneumoniae publication-title: mBio doi: 10.1128/mBio.00756-16 – volume: 127 start-page: 361 year: 2019 ident: B84 article-title: Antibiotic therapy as personalized medicine - general considerations and complicating factors publication-title: APMIS. doi: 10.1111/apm.12951 – year: 2020 ident: B65 article-title: Bacterial toxins in musculoskeletal infections publication-title: J Orthop Res. doi: 10.1002/jor.24683 – volume: 20 start-page: 981 year: 2014 ident: B78 article-title: Antimicrobial susceptibility testing in biofilm-growing bacteria publication-title: Clin Microbiol Infect. doi: 10.1111/1469-0691.12651 – volume: 8 start-page: 13040 year: 2018 ident: B86 article-title: A steam-based method to investigate biofilm publication-title: Sci Rep. doi: 10.1038/s41598-018-31437-y – volume: 46 start-page: 824 year: 2008 ident: B16 article-title: Evaluation of conventional microbiological procedures and molecular genetic techniques for diagnosis of infections in patients with implanted orthopedic devices publication-title: J Clin Microbiol. doi: 10.1128/JCM.01227-07 – volume: 466 start-page: 1716 year: 2008 ident: B17 article-title: Molecular identification of bacteria from aseptically loose implants publication-title: Clin Orthop Relat Res. doi: 10.1007/s11999-008-0263-y – volume: 370 start-page: 2408 year: 2014 ident: B38 article-title: Actionable diagnosis of neuroleptospirosis by next-generation sequencing publication-title: N Engl J Med. doi: 10.1056/NEJMoa1401268 – volume: 19 start-page: 9 year: 2018 ident: B77 article-title: Towards a genomics-informed, real-time, global pathogen surveillance system publication-title: Nat Rev Genet. doi: 10.1038/nrg.2017.88 – ident: B39 – volume: 21 start-page: 102039 year: 2019 ident: B64 article-title: An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis publication-title: Nanomedicine. doi: 10.1016/j.nano.2019.102039 – volume: 276 start-page: 111 year: 2014 ident: B3 article-title: Clinical presentation and treatment of orthopaedic implant-associated infection publication-title: J Intern Med. doi: 10.1111/joim.12233 – volume: 52 start-page: 3583 year: 2014 ident: B22 article-title: Evaluation of 16S rRNA gene PCR sensitivity and specificity for diagnosis of prosthetic joint infection: a prospective multicenter cross-sectional study publication-title: J Clin Microbiol. doi: 10.1128/JCM.01459-14 – volume: 9 start-page: 440 year: 2020 ident: B32 article-title: Metagenomic next-generation sequencing of synovial fluid demonstrates high accuracy in prosthetic joint infection diagnostics: mNGS for diagnosing PJI publication-title: Bone Joint Res. doi: 10.1302/2046-3758.97.BJR-2019-0325.R2 – volume: 100 start-page: 111 year: 2014 ident: B58 article-title: Quantification of confocal images of biofilms grown on irregular surfaces publication-title: J Microbiol Methods. doi: 10.1016/j.mimet.2014.02.020 – volume: 200 start-page: e00619 year: 2018 ident: B70 article-title: Distinct regulatory role of carbon catabolite protein A (CcpA) in oral streptococcal spxB expression publication-title: J Bacteriol. doi: 10.1128/JB.00619-17 – year: 2020 ident: B62 article-title: Adjuvant antibiotic-loaded bone cement: concerns with current use and research to make it work publication-title: J Orthop Res. doi: 10.1002/jor.24616 – volume: 65 start-page: 541 year: 2012 ident: B13 article-title: Multiplex PCR of sonication fluid accurately differentiates between prosthetic joint infection and aseptic failure publication-title: J Infect. doi: 10.1016/j.jinf.2012.08.018 – volume: 343 start-page: 42 year: 2013 ident: B21 article-title: Comparison of molecular and culture method in diagnosis of prosthetic joint infection publication-title: FEMS Microbiol Lett. doi: 10.1111/1574-6968.12125 – volume: 15 start-page: 1193 year: 2015 ident: B40 article-title: Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study publication-title: Lancet Infect Dis. doi: 10.1016/S1473-3099(15)00062-6 – volume: 46 start-page: 1134 year: 2019 ident: B2 article-title: Rates of total joint replacement in the United States: future projections to 2020-2040 using the national inpatient sample publication-title: J Rheumatol. doi: 10.3899/jrheum.170990 – volume: 56 start-page: e00402 year: 2018 ident: B27 article-title: Direct detection and identification of prosthetic joint infection pathogens in synovial fluid by metagenomic shotgun sequencing publication-title: J Clin Microbiol. doi: 10.1128/JCM.00402-18 – volume: 14 start-page: R207 year: 2005 ident: B9 article-title: Pharmacogenetics/genomics and personalized medicine publication-title: Hum Mol Genet. doi: 10.1093/hmg/ddi261 – volume: 129 start-page: 221.e11 year: 2016 ident: B6 article-title: Clinical presentation, risk factors, and outcomes of hematogenous prosthetic joint infection in patients with Staphylococcus aureus bacteremia publication-title: Am J Med. doi: 10.1016/j.amjmed.2015.09.006 – volume: 23 start-page: 154 year: 2017 ident: B49 article-title: Mycobacterium tuberculosis drug-resistance testing: challenges, recent developments and perspectives publication-title: Clin Microbiol Infect. doi: 10.1016/j.cmi.2016.10.022 – volume: 215 start-page: 1407 year: 2017 ident: B52 article-title: Viral pathogen detection by metagenomics and pan-viral group polymerase chain reaction in children with pneumonia lacking identifiable etiology publication-title: J Infect Dis. doi: 10.1093/infdis/jix148 – volume: 92 start-page: 210 year: 2018 ident: B53 article-title: Liquid biopsy for infectious diseases: sequencing of cell-free plasma to detect pathogen DNA in patients with invasive fungal disease publication-title: Diagn Microbiol Infect Dis. doi: 10.1016/j.diagmicrobio.2018.06.009 – volume: 380 start-page: 2327 year: 2019 ident: B44 article-title: Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis publication-title: N Engl J Med. doi: 10.1056/NEJMoa1803396 – volume: 15 start-page: 147 year: 2017 ident: B79 article-title: Approaches to biofilm-associated infections: the need for standardized and relevant biofilm methods for clinical applications publication-title: Expert Rev Anti Infect Ther. doi: 10.1080/14787210.2017.1262257 – volume: 5 start-page: 1236 year: 2010 ident: B85 article-title: Microtiter susceptibility testing of microbes growing on peg lids: a miniaturized biofilm model for high-throughput screening publication-title: Nat Protoc. doi: 10.1038/nprot.2010.71 – volume: 218 start-page: 1641 year: 2018 ident: B69 article-title: Group B Streptococcus biofilm regulatory protein A contributes to bacterial physiology and innate immune resistance publication-title: J Infect Dis. doi: 10.1093/infdis/jiy341 – volume: 48 start-page: 1208 year: 2010 ident: B12 article-title: Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants publication-title: J Clin Microbiol. doi: 10.1128/JCM.00006-10 – volume: 34 start-page: S339 year: 2019 ident: B57 article-title: Hip and knee section, diagnosis, algorithm: proceedings of international consensus on orthopedic infections publication-title: J Arthroplasty. doi: 10.1016/j.arth.2018.09.018 – volume: 47 start-page: 1878 year: 2009 ident: B11 article-title: Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication publication-title: J Clin Microbiol. doi: 10.1128/JCM.01686-08 – volume: 97 start-page: 54 year: 2020 ident: B46 article-title: Preliminary assessment of nanopore-based metagenomic sequencing for the diagnosis of prosthetic joint infection publication-title: Int J Infect Dis. doi: 10.1016/j.ijid.2020.05.044 – volume: 98 start-page: e14547 year: 2019 ident: B4 article-title: Incidence of surgical-site infection following open reduction and internal fixation of a distal femur fracture: an observational case-control study publication-title: Medicine. doi: 10.1097/MD.0000000000014547 – volume: 52 start-page: 1182 year: 2014 ident: B37 article-title: Prediction of Staphylococcus aureus antimicrobial resistance by whole-genome sequencing publication-title: J Clin Microbiol. doi: 10.1128/JCM.03117-13 – volume: 17 start-page: 643 year: 2018 ident: B74 article-title: Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation publication-title: Mol Cell Proteomics. doi: 10.1074/mcp.RA117.000461 – volume: 99 start-page: 108 year: 2020 ident: B30 article-title: Detecting the presence of bacteria in low-volume preoperative aspirated synovial fluid by metagenomic next-generation sequencing publication-title: Int J Infect Dis. doi: 10.1016/j.ijid.2020.07.039 – volume: 289 start-page: 21003 year: 2014 ident: B67 article-title: FbsC, a novel fibrinogen-binding protein, promotes Streptococcus agalactiae-host cell interactions publication-title: J Biol Chem. doi: 10.1074/jbc.M114.553073 – volume: 72 start-page: 444 year: 2017 ident: B83 article-title: In vitro activity of gentamicin as an adjunct to penicillin against biofilm group B Streptococcus publication-title: J Antimicrob Chemother. doi: 10.1093/jac/dkw447 – volume: 56 start-page: e1 year: 2013 ident: B1 article-title: Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America publication-title: Clin Infect Dis. doi: 10.1093/cid/cis966 – volume: 138 start-page: 60 year: 2017 ident: B35 article-title: Next-generation sequencing (NGS) in the microbiological world: how to make the most of your money publication-title: J Microbiol Methods. doi: 10.1016/j.mimet.2016.02.016 – volume: 33 start-page: 1309 year: 2018 ident: B56 article-title: The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria publication-title: J Arthroplasty. doi: 10.1016/j.arth.2018.02.078 – volume: 6 start-page: 310 year: 2016 ident: B8 article-title: Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis publication-title: Am J Nucl Med Mol Imaging. – volume: 199 start-page: 693 year: 2009 ident: B76 article-title: Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes publication-title: J Infect Dis. doi: 10.1086/596736 – volume: 357 start-page: 654 year: 2007 ident: B10 article-title: Sonication of removed hip and knee prostheses for diagnosis of infection publication-title: N Engl J Med. doi: 10.1056/NEJMoa061588 – volume: 96 start-page: 573 year: 2020 ident: B31 article-title: Metagenomic next generation sequencing improves diagnosis of prosthetic joint infection by detecting the presence of bacteria in periprosthetic tissues publication-title: Int J Infect Dis. doi: 10.1016/j.ijid.2020.05.125 – volume: 68 start-page: 2234 year: 2013 ident: B36 article-title: Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data publication-title: J Antimicrob Chemother. doi: 10.1093/jac/dkt180 – volume: 37 start-page: 2515 year: 2013 ident: B20 article-title: Prosthetic infection: improvement of diagnostic procedures using 16S ribosomal deoxyribonucleic acid polymerase chain reaction publication-title: Int Orthop. doi: 10.1007/s00264-013-2038-7 – volume: 16 start-page: 397 year: 2018 ident: B7 article-title: Implant infections: adhesion, biofilm formation and immune evasion publication-title: Nat Rev Microbiol. doi: 10.1038/s41579-018-0019-y – volume: 50 start-page: 583 year: 2012 ident: B19 article-title: Role of universal 16S rRNA gene PCR and sequencing in diagnosis of prosthetic joint infection publication-title: J Clin Microbiol. doi: 10.1128/JCM.00170-11 – volume: 100 start-page: 147 year: 2018 ident: B24 article-title: Diagnosis of periprosthetic joint infection: the potential of next-generation sequencing publication-title: J Bone Joint Surg Am. doi: 10.2106/JBJS.17.00434 – volume: 5 start-page: e1000422 year: 2009 ident: B71 article-title: Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiae publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000422 – volume: 34 start-page: 1514 year: 2019 ident: B33 article-title: Performance of sequencing assays in diagnosis of prosthetic joint infection: a systematic review and meta-analysis publication-title: J Arthroplasty. doi: 10.1016/j.arth.2019.02.044 – volume-title: Infectious Disease Next Generation Sequencing Based Diagnostic Devices: Microbial Identification and Detection of Antimicrobial Resistance and Virulence Markers year: 2016 ident: B50 – volume: 29 start-page: 831 year: 2019 ident: B55 article-title: Laboratory validation of a clinical metagenomic sequencing assay for pathogen detection in cerebrospinal fluid publication-title: Genome Res. doi: 10.1101/gr.238170.118 – volume: 83 start-page: 2966 year: 2015 ident: B63 article-title: Role of phenol-soluble modulins in formation of Staphylococcus aureus biofilms in synovial fluid publication-title: Infect Immun. doi: 10.1128/IAI.00394-15 – volume: 7 start-page: 53 year: 2020 ident: B47 article-title: Second periprosthetic joint infection caused by Streptococcus dysgalactiae: how genomic sequencing can help defining the best therapeutic strategy publication-title: Front Med. doi: 10.3389/fmed.2020.00053 – volume: 52 start-page: 922 year: 2018 ident: B61 article-title: Virulence determinants, biofilm production and antimicrobial susceptibility in Staphylococcus aureus causing device-associated infections in a Tunisian hospital publication-title: Int J Antimicrob Agents. doi: 10.1016/j.ijantimicag.2018.05.004 – volume: 21 start-page: 18 year: 2019 ident: B80 article-title: MBEC vs. MBIC: the lack of differentiation between biofilm reducing and inhibitory effects as a current problem in biofilm methodology publication-title: Biol Proced Online. doi: 10.1186/s12575-019-0106-0 – volume: 63 start-page: 17 year: 2011 ident: B5 article-title: Periprosthetic joint infection following Staphylococcus aureus bacteremia publication-title: J Infect. doi: 10.1016/j.jinf.2011.05.005 – volume: 55 start-page: 2334 year: 2017 ident: B28 article-title: Molecular diagnosis of orthopedic-device-related infection directly from sonication fluid by metagenomic sequencing publication-title: J Clin Microbiol. doi: 10.1128/JCM.00462-17 – volume: 79 start-page: 448 year: 2014 ident: B15 article-title: Low sensitivity of periprosthetic tissue PCR for prosthetic knee infection diagnosis publication-title: Diagn Microbiol Infect Dis. doi: 10.1016/j.diagmicrobio.2014.03.021 – volume: 78 start-page: 722 year: 2015 ident: B41 article-title: Diagnosing Balamuthia mandrillaris encephalitis with metagenomic deep sequencing publication-title: Ann Neurol. doi: 10.1002/ana.24499 – volume: 51 start-page: 2280 year: 2013 ident: B14 article-title: Rapid molecular microbiologic diagnosis of prosthetic joint infection publication-title: J Clin Microbiol. doi: 10.1128/JCM.00335-13 – volume: 50 start-page: 3501 year: 2012 ident: B18 article-title: Prosthetic joint infection diagnosis using broad-range PCR of biofilms dislodged from knee and hip arthroplasty surfaces using sonication publication-title: J Clin Microbiol. doi: 10.1128/JCM.00834-12 – volume: 7 start-page: 457 year: 2014 ident: B82 article-title: Human plasma enhances the expression of Staphylococcal microbial surface components recognizing adhesive matrix molecules promoting biofilm formation and increases antimicrobial tolerance in vitro publication-title: BMC Res Notes. doi: 10.1186/1756-0500-7-457 – volume: 56 start-page: e01351 year: 2018 ident: B23 article-title: Differential contributions of specimen types, culturing, and 16S rRNA sequencing in diagnosis of prosthetic joint infections publication-title: J Clin Microbiol. doi: 10.1128/JCM.01351-17 – volume: 95 start-page: 8 year: 2020 ident: B29 article-title: Comparison of broad-range polymerase chain reaction and metagenomic next-generation sequencing for the diagnosis of prosthetic joint infection publication-title: Int J Infect Dis. doi: 10.1016/j.ijid.2020.03.055 – volume: 20 start-page: 253 year: 2020 ident: B45 article-title: Can metagenomic next-generation sequencing identify the pathogens responsible for culture-negative prosthetic joint infection? publication-title: BMC Infect Dis. doi: 10.1186/s12879-020-04955-2 – volume: 80 start-page: 3975 year: 2012 ident: B66 article-title: CsrRS and environmental pH regulate group B Streptococcus adherence to human epithelial cells and extracellular matrix publication-title: Infect Immun. doi: 10.1128/IAI.00699-12 – volume: 20 start-page: 341 year: 2019 ident: B43 article-title: Clinical metagenomics publication-title: Nat Rev Genet. doi: 10.1038/s41576-019-0113-7 |
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| SubjectTerms | Antibiotics Antimicrobial agents Biofilms Diagnostic tests Genomes Global health Health care industry implant-related infection Infections Medicine Meta-analysis metagenomic sequencing Microorganisms minimal biofilm eradication concentration next-generation sequencing Orthopedics osteomyelitis Pathogens Patients Precision medicine Systematic review Transplants & implants |
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