Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression

Replication of the mitochondrial genome and expression of the genes it encodes both depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated nucleotide metabolism not only destabilises the mitochondrial genome, but also affects its transcription. Here, we report that a...

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Bibliographic Details
Published in:	The EMBO journal Vol. 42; no. 18; p. e113256
Main Authors:	Grotehans, Nils, McGarry, Lynn, Nolte, Hendrik, Xavier, Vanessa, Kroker, Moritz, Narbona‐Pérez, Álvaro Jesús, Deshwal, Soni, Giavalisco, Patrick, Langer, Thomas, MacVicar, Thomas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.09.2023 Springer Nature B.V John Wiley and Sons Inc
Subjects:	Deoxyribonucleotides Electron transport Electron transport chain EMBO32 EMBO57 Gene expression Genes Genomes Kinases Life Sciences Mitochondria Mitochondrial DNA Nucleoside-diphosphate kinase Nucleosides Nucleotides Oxidative phosphorylation Phosphorylation Ribonucleotides Transcription mitochondrial transcription NME6 nucleotide metabolism mitochondria mitochondrial DNA
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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