Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

Inherited retinal degenerations (IRDs) constitute a group of clinically and genetically diverse vision-impairing disorders. Retinitis pigmentosa (RP), the most common form of IRD, is characterized by gradual dysfunction and degeneration of rod photoreceptors, followed by the loss of cone photorecept...

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Bibliographic Details
Published in:	eLife Vol. 14
Main Authors:	Song, Hyun Beom, Campello, Laura, Mondal, Anupam, Chen, Holly Y, English, Milton A, Glen, Michael, Vanlandingham, Phillip, Farjo, Rafal, Swaroop, Anand
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 15.04.2025 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Animals Cell death Cellular stress response Cilia Corticosteroids Disease Models, Animal Female Genetic aspects Health aspects Leber congenital amaurosis Male Medical research Medicine Medicine, Experimental Mutation neuroprotection Organoids Photoreceptors Phototransduction Physiological aspects Proteins Rats Research Advance Reserpine Reserpine - pharmacology Reserpine - therapeutic use Retina Retinal degeneration Retinal Rod Photoreceptor Cells - drug effects Retinitis pigmentosa Retinitis Pigmentosa - drug therapy Retinitis Pigmentosa - genetics Retinitis Pigmentosa - pathology Rhodopsin Rhodopsin - genetics Rhodopsin - metabolism rhodopsin mutation Sex Factors small molecule drug Tomography Transcriptomes Visual acuity United States California retinal degeneration rat neuroprotection rhodopsin mutation retinitis pigmentosa medicine small molecule drug
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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