Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19

and are highly polymorphic pharmacogenes; however, clinically actionable genetic variability in drug metabolism due to these genes has been limited to a few common alleles. The identification and functional characterization of less-common open reading frame sequence variation might help to individua...

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Veröffentlicht in:	Drug metabolism and disposition Jg. 47; H. 4; S. 425
Hauptverfasser:	Devarajan, Sandhya, Moon, Irene, Ho, Ming-Fen, Larson, Nicholas B, Neavin, Drew R, Moyer, Ann M, Black, John L, Bielinski, Suzette J, Scherer, Steven E, Wang, Liewei, Weinshilboum, Richard M, Reid, Joel M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2019
ISSN:	1521-009X, 1521-009X
Online-Zugang:	Weitere Angaben
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