Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19

and are highly polymorphic pharmacogenes; however, clinically actionable genetic variability in drug metabolism due to these genes has been limited to a few common alleles. The identification and functional characterization of less-common open reading frame sequence variation might help to individua...

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Vydané v:	Drug metabolism and disposition Ročník 47; číslo 4; s. 425
Hlavní autori:	Devarajan, Sandhya, Moon, Irene, Ho, Ming-Fen, Larson, Nicholas B, Neavin, Drew R, Moyer, Ann M, Black, John L, Bielinski, Suzette J, Scherer, Steven E, Wang, Liewei, Weinshilboum, Richard M, Reid, Joel M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.04.2019
ISSN:	1521-009X, 1521-009X
On-line prístup:	Zistit podrobnosti o prístupe
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