Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies

This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by se...

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Veröffentlicht in:	Food chemistry Jg. 477; S. 143630
Hauptverfasser:	Liu, Lu, Barber, Elizabeth, Kellow, Nicole J., Williamson, Gary
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 15.06.2025
Schlagworte:	bioactive properties bioavailability Biological Availability blood chemical structure Clinical Trials as Topic Dietary Supplements - analysis Emulsification Encapsulation fenugreek Flavonoid food chemistry food matrix Food matrix interactions galactomannans Humans lecithins meta-analysis Polyphenols quercetin Quercetin - administration & dosage Quercetin - analysis Quercetin - pharmacokinetics Solid dispersion systematic review urine Encapsulation Polyphenols Solid dispersion Emulsification Flavonoid Food matrix interactions
ISSN:	0308-8146, 1873-7072, 1873-7072
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Abstract	This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by several factors. 1) Chemical structure: Quercetin-3-O-oligoglucosides exhibited 2-fold higher bioavailability than quercetin-3-O-glucoside, 10-fold higher than quercetin-3-O-rutinoside and ∼ 20-fold higher than quercetin aglycone. 2) Modification of physicochemical properties: In comparison to quercetin aglycone, the quercetin-3-O-glucoside-γ-cyclodextrin inclusion complex showed a 10.8-fold increase in bioavailability, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin phytosome, showed a 62- and 20.1-fold increase, respectively. 3) Food matrix effects: the addition of dietary fats and fibre increased bioavailability by ∼2-fold. This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans. •Quercetin bioavailability is increased by lipid complexation and glucosylation.•Increasing quercetin solubility and stability is not guaranteed to increase bioavailability.•Large increases in quercetin bioavailability are possible with appropriate formulation.
AbstractList	This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by several factors. 1) Chemical structure: Quercetin-3-O-oligoglucosides exhibited 2-fold higher bioavailability than quercetin-3-O-glucoside, 10-fold higher than quercetin-3-O-rutinoside and ∼ 20-fold higher than quercetin aglycone. 2) Modification of physicochemical properties: In comparison to quercetin aglycone, the quercetin-3-O-glucoside-γ-cyclodextrin inclusion complex showed a 10.8-fold increase in bioavailability, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin phytosome, showed a 62- and 20.1-fold increase, respectively. 3) Food matrix effects: the addition of dietary fats and fibre increased bioavailability by ∼2-fold. This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans. •Quercetin bioavailability is increased by lipid complexation and glucosylation.•Increasing quercetin solubility and stability is not guaranteed to increase bioavailability.•Large increases in quercetin bioavailability are possible with appropriate formulation. This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by several factors. 1) Chemical structure: Quercetin-3-O-oligoglucosides exhibited 2-fold higher bioavailability than quercetin-3-O-glucoside, 10-fold higher than quercetin-3-O-rutinoside and ~ 20-fold higher than quercetin aglycone. 2) Modification of physicochemical properties: In comparison to quercetin aglycone, the quercetin-3-O-glucoside-γ-cyclodextrin inclusion complex showed a 10.8-fold increase in bioavailability, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin phytosome, showed a 62- and 20.1-fold increase, respectively. 3) Food matrix effects: the addition of dietary fats and fibre increased bioavailability by ~2-fold. This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans. This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by several factors. 1) Chemical structure: Quercetin-3-O-oligoglucosides exhibited 2-fold higher bioavailability than quercetin-3-O-glucoside, 10-fold higher than quercetin-3-O-rutinoside and ∼ 20-fold higher than quercetin aglycone. 2) Modification of physicochemical properties: In comparison to quercetin aglycone, the quercetin-3-O-glucoside-γ-cyclodextrin inclusion complex showed a 10.8-fold increase in bioavailability, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin phytosome, showed a 62- and 20.1-fold increase, respectively. 3) Food matrix effects: the addition of dietary fats and fibre increased bioavailability by ∼2-fold. This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans. This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by several factors. 1) Chemical structure: Quercetin-3-O-oligoglucosides exhibited 2-fold higher bioavailability than quercetin-3-O-glucoside, 10-fold higher than quercetin-3-O-rutinoside and ∼ 20-fold higher than quercetin aglycone. 2) Modification of physicochemical properties: In comparison to quercetin aglycone, the quercetin-3-O-glucoside-γ-cyclodextrin inclusion complex showed a 10.8-fold increase in bioavailability, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin phytosome, showed a 62- and 20.1-fold increase, respectively. 3) Food matrix effects: the addition of dietary fats and fibre increased bioavailability by ∼2-fold. This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans.This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024. The bioavailability of quercetin in humans was affected by several factors. 1) Chemical structure: Quercetin-3-O-oligoglucosides exhibited 2-fold higher bioavailability than quercetin-3-O-glucoside, 10-fold higher than quercetin-3-O-rutinoside and ∼ 20-fold higher than quercetin aglycone. 2) Modification of physicochemical properties: In comparison to quercetin aglycone, the quercetin-3-O-glucoside-γ-cyclodextrin inclusion complex showed a 10.8-fold increase in bioavailability, while the self-emulsifying fenugreek galactomannans and lecithin encapsulation, and lecithin phytosome, showed a 62- and 20.1-fold increase, respectively. 3) Food matrix effects: the addition of dietary fats and fibre increased bioavailability by ∼2-fold. This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans.
ArticleNumber	143630
Author	Barber, Elizabeth Kellow, Nicole J. Liu, Lu Williamson, Gary
Author_xml	– sequence: 1 givenname: Lu surname: Liu fullname: Liu, Lu organization: Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia – sequence: 2 givenname: Elizabeth surname: Barber fullname: Barber, Elizabeth organization: Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia – sequence: 3 givenname: Nicole J. surname: Kellow fullname: Kellow, Nicole J. organization: Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia – sequence: 4 givenname: Gary surname: Williamson fullname: Williamson, Gary email: gary.williamson1@monash.edu organization: Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, 264 Ferntree Gully Road, Notting Hill, VIC 3168, Australia
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Cites_doi	10.1016/j.jff.2017.07.047 10.1016/j.jff.2018.07.035 10.1080/10715760600771400 10.1016/j.bcp.2017.03.012 10.1021/acsomega.2c05929 10.3945/ajcn.2010.29924 10.1021/acs.jafc.1c01388 10.1007/s00394-015-1084-x 10.3390/nu16010161 10.1016/j.foodchem.2021.130152 10.1080/07315724.2003.10719296 10.4014/jmb.1907.07003 10.1080/10715769900301141 10.1016/j.foodres.2016.02.013 10.1007/s13318-018-0517-3 10.1016/j.ebiom.2019.08.069 10.1111/1750-3841.13079 10.1016/j.jff.2021.104501 10.1017/S0007114519002137 10.1016/j.abb.2010.06.036 10.1093/ije/dyn065 10.1016/j.jff.2023.105707 10.1046/j.1365-2125.2003.02007.x 10.1111/bcp.14094 10.1177/00912700122010366 10.1002/(SICI)1097-0010(199707)74:3<331::AID-JSFA806>3.0.CO;2-C 10.1093/ajcn/68.1.60 10.1079/BJN20061809 10.1080/09168451.2018.1498726 10.1016/j.carbpol.2012.11.073 10.1021/jf030582e 10.1017/S0007114515000537 10.1016/j.colcom.2021.100493 10.1093/jn/131.3.745 10.1016/j.phymed.2023.154979 10.1016/j.wasman.2021.03.033 10.1021/jf3001857 10.1016/j.foodres.2015.11.017 10.1016/j.foodchem.2024.140262 10.1016/S0006-2952(03)00039-X 10.1080/10715760100300261 10.1016/j.fhfh.2022.100113 10.1016/j.foodhyd.2023.109502 10.1016/j.jff.2021.104663 10.1016/j.bcp.2015.09.022 10.1002/mnfr.201200619 10.1111/j.1750-3841.2012.02934.x 10.1021/jf9024823 10.1016/j.ejps.2013.08.018 10.1016/j.foodchem.2015.03.024 10.1016/j.indcrop.2020.112250 10.1016/j.ebiom.2018.12.052 10.1016/j.trsl.2019.07.005 10.1093/jn/138.5.885 10.2147/IJN.S318416 10.1016/j.stemcr.2021.01.005 10.1007/s00018-020-03564-1 10.1016/S0014-5793(97)01367-7 10.1039/D1FO00275A 10.1207/s15327914nc5401_3 10.1016/S0304-3835(97)04644-2 10.1136/bmj.b2535 10.1016/S0009-9120(02)00397-1 10.1017/S0007114511003242 10.1016/j.fbio.2021.101297 10.1007/s10753-021-01479-y 10.1016/j.foodchem.2015.04.035 10.1039/C5FO00155B 10.1111/j.2042-7158.1998.tb06183.x 10.1002/mnfr.201300234 10.1016/j.biortech.2011.08.029 10.1016/j.fbio.2024.105352 10.47750/pnr.2022.13.S06.131 10.1002/mnfr.202100613 10.1016/j.plaphy.2021.05.023 10.1016/j.foodchem.2024.140163 10.1016/j.crfs.2022.01.002
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Keywords	Encapsulation Polyphenols Solid dispersion Emulsification Flavonoid Food matrix interactions
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References	Sterne, Savovic, Page, Elbers, Blencowe, Boutron, Higgins (bb0355) 2019; 366 Kim, Jiang, Ogrodnik, Chen, Zhu, Lohmeier, Lerman (bb0190) 2019; 213 Justice, Nambiar, Tchkonia, LeBrasseur, Pascual, Hashmi, Kirkland (bb0165) 2019; 40 Shi, Williamson (bb0335) 2015; 6 Zhu, Song, Zhao (bb0415) 2021; 43 Makino, Takano, Kita, Nishimukai (bb0240) 2018; 82 Lin, Chen, Farag, Teng, Cao (bb0220) 2024; 62 Behera, Mishra, Mohapatra (bb0015) 2021; 44 Hollman, vanTrijp, Buysman, VanderGaag, Mengelers, deVries, Katan (bb0140) 1997; 418 Hollman, van het Hof, Tijburgh, Katan (bb0135) 2001; 34 Mangoni, Jackson (bb0245) 2004; 57 Koli, Erlund, Jula, Marniemi, Mattila, Alfthan (bb0195) 2010; 58 Lee, Mitchell (bb0205) 2012; 60 Riva, Ronchi, Petrangolini, Bosisio, Allegrini (bb0320) 2019; 44 Trakooncharoenvit, Hara, Hira (bb0365) 2021; 69 Abdulhameed, Hassan, Alwafi, Alzobai (bb0005) 2022; 13 Boonpawa, Moradi, Spenkelink, Rietjens, Punt (bb0025) 2015; 98 Erlund, Freese, Marnietni, Hakala, Alfthan (bb0080) 2006; 54 Guo, Mah, Davis, Jalili, Ferruzzi, Chun, Bruno (bb0110) 2013; 57 Wiczkowski, Romaszko, Bucinski, Szawara-Nowak, Honke, Zielinski, Piskula (bb0385) 2008; 138 Li, Yang, Ying, Yu, Sanguansri, Augustin (bb0215) 2020; 147 Zhang, Amin, Zhang, Yu, Jing, Wang, Lyu, Yu (bb0405) 2025; 463 Flory, Sus, Haas, Jehle, Kienhofer, Waehler, Frank (bb0090) 2021; 65 Zhu, Ding, Ren, Xi, Liu (bb0420) 2024; 458 Cheng, Zhang, Wu, Liu, Zhou, Tan, Feng, Peng (bb0040) 2023; 119 Barani, Sangiovanni, Angarano, Rajizadeh, Mehrabani, Piazza, Nematollahi (bb0010) 2021; 16 Goldberg, Yan, Soleas (bb0095) 2003; 36 Jaganath, Mullen, Edwards, Crozier (bb0150) 2006; 40 Zhan, Meng, Yan, Tan, Khurshid, Li, Wang (bb0400) 2024; 457 Egert (bb0065) 2012; 107 Graefe, Wittig, Mueller, Riethling, Uehleke, Drewelow, Veit (bb0100) 2001; 41 Ichwan, Walker, Nicola, Ludwig-Muller, Bottcher, Overall, Kempermann (bb0145) 2021; 16 Rodrigues, Marques, Hacke, Loubet Filho, Cazarin, Mariutti (bb0325) 2022; 5 de Vries, Hollman, Meyboom, Buysman, Zock, van Staveren, Katan (bb0370) 1998; 68 Boulton, Walle, Walle (bb0030) 1998; 50 Patsopoulos, Evangelou, Ioannidis (bb0295) 2008; 37 Wójcicki, Gawrońska-Szklarz, Bieganowski, Patalan, Smulski, Samochowiec, Zakrzewski (bb0395) 1995; 27 Pérez-Jiménez, Hubert, Hooper, Cassidy, Manach, Williamson, Scalbert (bb0300) 2010; 92 Ma, Huang, Yin, Yu, Yang (bb0230) 2021; 360 Drenth-van Maanen, Wilting, Jansen (bb0060) 2020; 86 Elferink, Bruekers, Veeneman, Boltje (bb0075) 2020; 77 Magar, Sohng (bb0235) 2020; 30 Nakamura, Murota, Kumamoto, Misumi, Bando, Ikushiro, Takahashi, Sekido, Kato, Terao (bb0280) 2014; 58 Singh, Arif, Bajguz, Hayat (bb0345) 2021; 166 Kashino, Murota, Matsuda, Tomotake, Hamano, Mukai, Terao (bb0175) 2015; 80 Chomphen, Yamanont, Morales (bb0045) 2024; 16 Egert, Wolffram, Schulze, Langguth, Hubbermann, Schwarz, Müller (bb0070) 2012; 107 Meng, Maliakal, Lu, Lee, Yang (bb0255) 2004; 52 Moher, Liberati, Tetzlaff, Altman, Group, P (bb0260) 2009; 339 Hollman, van Trijp, Mengelers, de Vries, Katan (bb0130) 1997; 114 Lu, Ho, Huang (bb0225) 2017; 37 Zhou, Zheng, McClements (bb0410) 2021; 12 Shiromani, Patil, Nallamuthu, R, R., Singsit, D., & Anand, T. (bb0340) 2023; 3 Hollman, Bijsman, van Gameren, Cnossen, de Vries, Katan (bb0125) 1999; 31 Nishijima, Takida, Saito, Ikeda, Iwai (bb0285) 2015; 113 Harris, Brunton, Tiwari, Cummins (bb0115) 2015; 187 Su, Zhou, Xu, Huang, Li, He, Cheng, Wang (bb0360) 2024; 149 Gregor, Auernigg-Haselmaier, Malleier, Bruckberger, Séneca, Pjevac, Pignitter, Duszka (bb0105) 2023; 107 Kapoor, Moriwaki, Uguri, Timm, Kuroiwa (bb0170) 2021; 85 Costa, de Sousa, Dos Santos Alves, Goes, Pereira, Alves, Gondim (bb0050) 2021; 44 Joseph, Shanmughan, Balakrishnan, Maliakel, Krishnakumar (bb0160) 2022; 7 Williamson, Clifford (bb0390) 2017; 139 Jiang, Engelhardt, Thrane, Maiwald, Stark (bb0155) 2015; 183 Musther, Olivares-Morales, Hatley, Liu, Rostami Hodjegan (bb0275) 2014; 57 Osojnik Crnivec, Skrt, Seremet, Sternisa, Farcnik, Strumbelj, Poklar Ulrih (bb0290) 2021; 126 McClements, Saliva-Trujillo, Zhang, Zhang, Zou, Yao, Xiao (bb0250) 2016; 88 Sterne, Hernan, Reeves, Savovic, Berkman, Viswanathan, Higgins (bb0350) 2016; 355 de Vries, Hollman, van Amersfoort, Olthof, Katan (bb0375) 2001; 131 Fang, Cheng, Zhang, Ma, Yang, Hou, Deng, Hou, Bai (bb0085) 2021; 82 Hickson, Langhi Prata, Bobart, Evans, Giorgadze, Hashmi, Kirkland (bb0120) 2019; 47 Perez-Moral, Saha, Philo, Hart, Winterbone, Hollands, Curtis (bb0305) 2018; 48 Li, Konecke, Harich, Wegiel, Taylor, Edgar (bb0210) 2013; 92 Weignerova, Marhol, Gerstorferova, Kren (bb0380) 2012; 115 Kim, Kim, Sung (bb0185) 2003; 22 Bondonno, Bondonno, Ward, Woodman, Hodgson, Croft (bb0020) 2020; 123 Kupikowska-Stobba, Niu, Klojdová, Agregán, Lorenzo, Kasprzak (bb0200) 2024 Day, Gee, DuPont, Johnson, Williamson (bb0055) 2003; 65 Price, Rhodes (bb0315) 1997; 74 Kaushik, O’Fallon, Clarkson, Dunne, Conca, Michniak-Kohn (bb0180) 2012; 77 Sankaranarayanan, Sekhon, Ambat, Nelson, Jose, Bhat, Scaria (bb0330) 2021; 22 Mullen, Edwards, Crozier (bb0265) 2006; 96 Murota, Matsuda, Kashino, Fujikura, Nakamura, Kato, Shimizu, Okuyama, Tanaka, Koda, Sekido, Terao (bb0270) 2010; 501 Petersen, Egert, Bosy-Westphal, Muller, Wolffram, Hubbermann, Schwarz (bb0310) 2016; 88 Burak, Brüll, Langguth, Zimmermann, Stoffel-Wagner, Sausen, Egert (bb0035) 2017; 56 Zhu (10.1016/j.foodchem.2025.143630_bb0415) 2021; 43 Jiang (10.1016/j.foodchem.2025.143630_bb0155) 2015; 183 Moher (10.1016/j.foodchem.2025.143630_bb0260) 2009; 339 Boonpawa (10.1016/j.foodchem.2025.143630_bb0025) 2015; 98 Mullen (10.1016/j.foodchem.2025.143630_bb0265) 2006; 96 Trakooncharoenvit (10.1016/j.foodchem.2025.143630_bb0365) 2021; 69 Fang (10.1016/j.foodchem.2025.143630_bb0085) 2021; 82 Shi (10.1016/j.foodchem.2025.143630_bb0335) 2015; 6 Singh (10.1016/j.foodchem.2025.143630_bb0345) 2021; 166 Harris (10.1016/j.foodchem.2025.143630_bb0115) 2015; 187 Zhang (10.1016/j.foodchem.2025.143630_bb0405) 2025; 463 Chomphen (10.1016/j.foodchem.2025.143630_bb0045) 2024; 16 Flory (10.1016/j.foodchem.2025.143630_bb0090) 2021; 65 Williamson (10.1016/j.foodchem.2025.143630_bb0390) 2017; 139 Graefe (10.1016/j.foodchem.2025.143630_bb0100) 2001; 41 Nakamura (10.1016/j.foodchem.2025.143630_bb0280) 2014; 58 Rodrigues (10.1016/j.foodchem.2025.143630_bb0325) 2022; 5 Su (10.1016/j.foodchem.2025.143630_bb0360) 2024; 149 Ichwan (10.1016/j.foodchem.2025.143630_bb0145) 2021; 16 Lin (10.1016/j.foodchem.2025.143630_bb0220) 2024; 62 Drenth-van Maanen (10.1016/j.foodchem.2025.143630_bb0060) 2020; 86 Weignerova (10.1016/j.foodchem.2025.143630_bb0380) 2012; 115 Abdulhameed (10.1016/j.foodchem.2025.143630_bb0005) 2022; 13 Justice (10.1016/j.foodchem.2025.143630_bb0165) 2019; 40 Zhou (10.1016/j.foodchem.2025.143630_bb0410) 2021; 12 Burak (10.1016/j.foodchem.2025.143630_bb0035) 2017; 56 Meng (10.1016/j.foodchem.2025.143630_bb0255) 2004; 52 Costa (10.1016/j.foodchem.2025.143630_bb0050) 2021; 44 Egert (10.1016/j.foodchem.2025.143630_bb0070) 2012; 107 Kapoor (10.1016/j.foodchem.2025.143630_bb0170) 2021; 85 Shiromani (10.1016/j.foodchem.2025.143630_bb0340) 2023; 3 Magar (10.1016/j.foodchem.2025.143630_bb0235) 2020; 30 Mangoni (10.1016/j.foodchem.2025.143630_bb0245) 2004; 57 Barani (10.1016/j.foodchem.2025.143630_bb0010) 2021; 16 Kashino (10.1016/j.foodchem.2025.143630_bb0175) 2015; 80 Hollman (10.1016/j.foodchem.2025.143630_bb0135) 2001; 34 Goldberg (10.1016/j.foodchem.2025.143630_bb0095) 2003; 36 Sterne (10.1016/j.foodchem.2025.143630_bb0350) 2016; 355 Hollman (10.1016/j.foodchem.2025.143630_bb0125) 1999; 31 Joseph (10.1016/j.foodchem.2025.143630_bb0160) 2022; 7 Osojnik Crnivec (10.1016/j.foodchem.2025.143630_bb0290) 2021; 126 Behera (10.1016/j.foodchem.2025.143630_bb0015) 2021; 44 Jaganath (10.1016/j.foodchem.2025.143630_bb0150) 2006; 40 Ma (10.1016/j.foodchem.2025.143630_bb0230) 2021; 360 de Vries (10.1016/j.foodchem.2025.143630_bb0370) 1998; 68 Makino (10.1016/j.foodchem.2025.143630_bb0240) 2018; 82 Perez-Moral (10.1016/j.foodchem.2025.143630_bb0305) 2018; 48 Hickson (10.1016/j.foodchem.2025.143630_bb0120) 2019; 47 Pérez-Jiménez (10.1016/j.foodchem.2025.143630_bb0300) 2010; 92 Zhan (10.1016/j.foodchem.2025.143630_bb0400) 2024; 457 Cheng (10.1016/j.foodchem.2025.143630_bb0040) 2023; 119 Lee (10.1016/j.foodchem.2025.143630_bb0205) 2012; 60 Kim (10.1016/j.foodchem.2025.143630_bb0185) 2003; 22 Gregor (10.1016/j.foodchem.2025.143630_bb0105) 2023; 107 Li (10.1016/j.foodchem.2025.143630_bb0215) 2020; 147 Musther (10.1016/j.foodchem.2025.143630_bb0275) 2014; 57 Wiczkowski (10.1016/j.foodchem.2025.143630_bb0385) 2008; 138 Murota (10.1016/j.foodchem.2025.143630_bb0270) 2010; 501 Koli (10.1016/j.foodchem.2025.143630_bb0195) 2010; 58 Sterne (10.1016/j.foodchem.2025.143630_bb0355) 2019; 366 Riva (10.1016/j.foodchem.2025.143630_bb0320) 2019; 44 Egert (10.1016/j.foodchem.2025.143630_bb0065) 2012; 107 Patsopoulos (10.1016/j.foodchem.2025.143630_bb0295) 2008; 37 Nishijima (10.1016/j.foodchem.2025.143630_bb0285) 2015; 113 Li (10.1016/j.foodchem.2025.143630_bb0210) 2013; 92 Zhu (10.1016/j.foodchem.2025.143630_bb0420) 2024; 458 McClements (10.1016/j.foodchem.2025.143630_bb0250) 2016; 88 Hollman (10.1016/j.foodchem.2025.143630_bb0130) 1997; 114 de Vries (10.1016/j.foodchem.2025.143630_bb0375) 2001; 131 Lu (10.1016/j.foodchem.2025.143630_bb0225) 2017; 37 Petersen (10.1016/j.foodchem.2025.143630_bb0310) 2016; 88 Hollman (10.1016/j.foodchem.2025.143630_bb0140) 1997; 418 Kaushik (10.1016/j.foodchem.2025.143630_bb0180) 2012; 77 Day (10.1016/j.foodchem.2025.143630_bb0055) 2003; 65 Kim (10.1016/j.foodchem.2025.143630_bb0190) 2019; 213 Kupikowska-Stobba (10.1016/j.foodchem.2025.143630_bb0200) 2024 Boulton (10.1016/j.foodchem.2025.143630_bb0030) 1998; 50 Sankaranarayanan (10.1016/j.foodchem.2025.143630_bb0330) 2021; 22 Guo (10.1016/j.foodchem.2025.143630_bb0110) 2013; 57 Elferink (10.1016/j.foodchem.2025.143630_bb0075) 2020; 77 Erlund (10.1016/j.foodchem.2025.143630_bb0080) 2006; 54 Price (10.1016/j.foodchem.2025.143630_bb0315) 1997; 74 Wójcicki (10.1016/j.foodchem.2025.143630_bb0395) 1995; 27 Bondonno (10.1016/j.foodchem.2025.143630_bb0020) 2020; 123
References_xml	– volume: 107 year: 2023 ident: bb0105 article-title: Fiber consumption stimulates the activity of microbial bile salt hydrolases publication-title: Journal of Functional Foods – volume: 501 start-page: 91 year: 2010 end-page: 97 ident: bb0270 article-title: α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans publication-title: Archives of Biochemistry and Biophysics – volume: 88 start-page: 140 year: 2016 end-page: 152 ident: bb0250 article-title: Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions publication-title: Food Research International – volume: 7 start-page: 46825 year: 2022 end-page: 46832 ident: bb0160 article-title: Enhanced bioavailability and pharmacokinetics of a natural self- emulsifying reversible hybrid-hydrogel system of quercetin: A randomized double-blinded comparative crossover study publication-title: ACS Omega – volume: 92 start-page: 2033 year: 2013 end-page: 2040 ident: bb0210 article-title: Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability publication-title: Carbohydrate Polymers – volume: 3 year: 2023 ident: bb0340 article-title: Shellac/caseinate as a composite nanocarrier for improved bioavailability of quercetin publication-title: Food Hydrocolloids for Health – volume: 86 start-page: 1921 year: 2020 end-page: 1930 ident: bb0060 article-title: Prescribing medicines to older people-how to consider the impact of ageing on human organ and body functions publication-title: British Journal of Clinical Pharmacology – volume: 57 start-page: 280 year: 2014 end-page: 291 ident: bb0275 article-title: Animal versus human oral drug bioavailability: Do they correlate? publication-title: European Journal of Pharmaceutical Sciences – volume: 85 year: 2021 ident: bb0170 article-title: Bioavailability of dietary isoquercitrin-gamma-cyclodextrin molecular inclusion complex in Sprague-Dawley rats and healthy humans publication-title: Journal of Functional Foods – volume: 60 start-page: 3874 year: 2012 end-page: 3881 ident: bb0205 article-title: Pharmacokinetics of quercetin absorption from apples and onions in healthy humans publication-title: Journal of Agricultural and Food Chemistry – volume: 16 start-page: 6983 year: 2021 end-page: 7022 ident: bb0010 article-title: Phytosomes as innovative delivery Systems for Phytochemicals: A comprehensive review of literature publication-title: International Journal of Nanomedicine – volume: 74 start-page: 331 year: 1997 end-page: 339 ident: bb0315 article-title: Analysis of the major Flavonol glycosides present in four varieties of onion ( publication-title: Journal of the Science of Food and Agriculture – volume: 98 start-page: 690 year: 2015 end-page: 702 ident: bb0025 article-title: Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites publication-title: Biochemical Pharmacology – volume: 77 start-page: 4799 year: 2020 end-page: 4826 ident: bb0075 article-title: A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine : “a gut feeling” publication-title: Cellular and Molecular Life Sciences – volume: 6 start-page: 1443 year: 2015 end-page: 1448 ident: bb0335 article-title: Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: A randomized, single-blinded, cross-over study publication-title: Food & Function – volume: 52 start-page: 935 year: 2004 end-page: 942 ident: bb0255 article-title: Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice publication-title: Journal of Agricultural and Food Chemistry – volume: 5 start-page: 228 year: 2022 end-page: 233 ident: bb0325 article-title: Trust your gut: Bioavailability and bioaccessibility of dietary compounds publication-title: Current Research in Food Science – volume: 463 year: 2025 ident: bb0405 article-title: The application of dietary fibre as microcapsule wall material in food processing publication-title: Food Chemistry – volume: 92 start-page: 801 year: 2010 end-page: 809 ident: bb0300 article-title: Urinary metabolites as biomarkers of polyphenol intake in humans: A systematic review publication-title: The American Journal of Clinical Nutrition – volume: 82 start-page: 2007 year: 2018 end-page: 2011 ident: bb0240 article-title: Influence of long-term feeding of high-fat diet on quercetin and fat absorption from the small intestine in lymph duct-cannulated rats publication-title: Bioscience, Biotechnology, and Biochemistry – volume: 355 year: 2016 ident: bb0350 article-title: ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions publication-title: The BMJ – volume: 41 start-page: 492 year: 2001 end-page: 499 ident: bb0100 article-title: Pharmacokinetics and bioavailability of quercetin glycosides in humans publication-title: The Journal of Clinical Pharmacology – volume: 40 start-page: 1035 year: 2006 end-page: 1046 ident: bb0150 article-title: The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man publication-title: Free Radical Research – volume: 88 start-page: 159 year: 2016 end-page: 165 ident: bb0310 article-title: Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources publication-title: Food Research International – volume: 123 start-page: 182 year: 2020 end-page: 189 ident: bb0020 article-title: Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease publication-title: British Journal of Nutrition – volume: 68 start-page: 60 year: 1998 end-page: 65 ident: bb0370 article-title: Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake publication-title: American Journal of Clinical Nutrition – volume: 62 year: 2024 ident: bb0220 article-title: A modified self-micro emulsifying liposome for bioavailability enhancement of quercetin and its biological effects publication-title: Food Bioscience – volume: 22 start-page: 217 year: 2003 end-page: 223 ident: bb0185 article-title: Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers publication-title: Journal of the American College of Nutrition – volume: 119 year: 2023 ident: bb0040 article-title: Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review publication-title: Phytomedicine – volume: 366 year: 2019 ident: bb0355 article-title: RoB 2: A revised tool for assessing risk of bias in randomised trials publication-title: The BMJ – volume: 36 start-page: 79 year: 2003 end-page: 87 ident: bb0095 article-title: Absorption of three wine-related polyphenols in three different matrices by healthy subjects publication-title: Clinical Biochemistry – volume: 50 start-page: 243 year: 1998 end-page: 249 ident: bb0030 article-title: Extensive binding of the bioflavonoid quercetin to human plasma proteins publication-title: Journal of Pharmacy and Pharmacology – volume: 166 start-page: 10 year: 2021 end-page: 19 ident: bb0345 article-title: The role of quercetin in plants publication-title: Plant Physiology and Biochemistry – volume: 58 start-page: 310 year: 2014 end-page: 317 ident: bb0280 article-title: Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans publication-title: Molecular Nutrition & Food Research – volume: 16 start-page: 548 year: 2021 end-page: 565 ident: bb0145 article-title: Apple Peel and flesh contain pro-neurogenic compounds publication-title: Stem Cell Reports – volume: 107 start-page: 539 year: 2012 end-page: 546 ident: bb0065 article-title: Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules publication-title: British Journal of Nutrition – volume: 107 start-page: 539 year: 2012 end-page: 546 ident: bb0070 article-title: Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules publication-title: British Journal of Nutrition – volume: 131 start-page: 745 year: 2001 end-page: 748 ident: bb0375 article-title: Red wine is a poor source of bioavailable flavonols in men publication-title: The Journal of Nutrition – volume: 65 start-page: 1199 year: 2003 end-page: 1206 ident: bb0055 article-title: Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter publication-title: Biochemical Pharmacology – volume: 213 start-page: 112 year: 2019 end-page: 123 ident: bb0190 article-title: Increased renal cellular senescence in murine high-fat diet: Effect of the senolytic drug quercetin publication-title: Translational Research – volume: 44 start-page: 169 year: 2019 end-page: 177 ident: bb0320 article-title: Improved Oral absorption of quercetin from quercetin Phytosome®, a new delivery system based on food grade lecithin publication-title: European Journal of Drug Metabolism and Pharmacokinetics – volume: 96 start-page: 107 year: 2006 end-page: 116 ident: bb0265 article-title: Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions publication-title: British Journal of Nutrition – volume: 147 year: 2020 ident: bb0215 article-title: Analysis of polyphenols in apple pomace: A comparative study of different extraction and hydrolysis procedures publication-title: Industrial Crops and Products – volume: 43 year: 2021 ident: bb0415 article-title: Potential applications and preliminary mechanism of action of dietary polyphenols against hyperuricemia: A review publication-title: Food Bioscience – volume: 360 year: 2021 ident: bb0230 article-title: Bioavailability of quercetin in zein-based colloidal particles-stabilized Pickering emulsions investigated by the in vitro digestion coupled with Caco-2 cell monolayer model publication-title: Food Chemistry – volume: 149 year: 2024 ident: bb0360 article-title: Enhancing the bioavailability of quercetin via the construction of carboxymethylated curdlan/quercetin nanocomplex publication-title: Food Hydrocolloids – volume: 138 start-page: 885 year: 2008 end-page: 888 ident: bb0385 article-title: Quercetin from shallots ( publication-title: The Journal of Nutrition – volume: 126 start-page: 476 year: 2021 end-page: 486 ident: bb0290 article-title: Waste streams in onion production: Bioactive compounds, quercetin and use of antimicrobial and antioxidative properties publication-title: Waste Management – volume: 48 start-page: 410 year: 2018 end-page: 419 ident: bb0305 article-title: Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from in vitro models and a human bioavailability study publication-title: Journal of Functional Foods – volume: 37 start-page: 1148 year: 2008 end-page: 1157 ident: bb0295 article-title: Sensitivity of between-study heterogeneity in meta-analysis: Proposed metrics and empirical evaluation publication-title: International Journal of Epidemiology – volume: 22 year: 2021 ident: bb0330 article-title: Screening of human gut bacterial culture collection identifies species that biotransform quercetin into metabolites with anticancer properties. International journal of molecular publication-title: Science – year: 2024 ident: bb0200 article-title: Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats publication-title: Food Chemistry – volume: 44 year: 2021 ident: bb0015 article-title: Physicochemical study of dietary fiber methylcellulose and human intestinal bile salt micellar aggregates publication-title: Colloid and Interface Science Communications – volume: 16 year: 2024 ident: bb0045 article-title: Flavonoid metabolites in serum and urine after the ingestion of selected tropical fruits publication-title: Nutrients – volume: 113 start-page: 1531 year: 2015 end-page: 1538 ident: bb0285 article-title: Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects publication-title: British Journal of Nutrition – volume: 339 year: 2009 ident: bb0260 article-title: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement publication-title: The BMJ – volume: 418 start-page: 152 year: 1997 end-page: 156 ident: bb0140 article-title: Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man publication-title: Federation of European Biochemical Societies letters – volume: 27 start-page: 141 year: 1995 end-page: 146 ident: bb0395 article-title: Comparative pharmacokinetics and bioavailability of flavonoid glycosides of publication-title: Materia Medica Polona – volume: 12 start-page: 3420 year: 2021 end-page: 3432 ident: bb0410 article-title: Encapsulation of lipophilic polyphenols in plant-based nanoemulsions: Impact of carrier oil on lipid digestion and curcumin, resveratrol and quercetin bioaccessibility publication-title: Food & Function – volume: 56 start-page: 343 year: 2017 end-page: 353 ident: bb0035 article-title: Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans publication-title: European Journal of Nutrition – volume: 114 start-page: 139 year: 1997 end-page: 140 ident: bb0130 article-title: Bioavailability of the dietary antioxidant flavonol quercetin in man publication-title: Cancer Letters – volume: 13 start-page: 981 year: 2022 end-page: 991 ident: bb0005 article-title: Enhancing the bioavailability of quercetin by concomitant administration with enzyme inhibitor publication-title: Journal of Pharmaceutical Negative Results – volume: 44 start-page: 2033 year: 2021 end-page: 2043 ident: bb0050 article-title: Anti-inflammatory and Hepatoprotective effects of quercetin in an experimental model of rheumatoid arthritis publication-title: Inflammation – volume: 77 start-page: H231 year: 2012 end-page: H238 ident: bb0180 article-title: Comparison of quercetin pharmacokinetics following oral supplementation in humans publication-title: Journal of Food Science – volume: 57 start-page: 6 year: 2004 end-page: 14 ident: bb0245 article-title: Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications publication-title: British Journal of Clinical Pharmacology – volume: 47 start-page: 446 year: 2019 end-page: 456 ident: bb0120 article-title: Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease publication-title: EBioMedicine – volume: 34 start-page: 297 year: 2001 end-page: 300 ident: bb0135 article-title: Addition of milk does not affect the absorption of flavonols from tea in man publication-title: Free Radical Research – volume: 115 start-page: 222 year: 2012 end-page: 227 ident: bb0380 article-title: Preparatory production of quercetin-3-beta-D-glucopyranoside using alkali-tolerant thermostable alpha-L-rhamnosidase from publication-title: Bioresource Technology – volume: 187 start-page: 135 year: 2015 end-page: 139 ident: bb0115 article-title: Human exposure modelling of quercetin in onions ( publication-title: Food Chemistry – volume: 69 start-page: 5907 year: 2021 end-page: 5916 ident: bb0365 article-title: Combination of alpha-Glycosyl-Isoquercitrin and soybean Fiber promotes quercetin bioavailability and glucagon-like Peptide-1 secretion and improves glucose homeostasis in rats fed a high-fat high-sucrose diet publication-title: Journal of Agricultural and Food Chemistry – volume: 457 year: 2024 ident: bb0400 article-title: A novel cascade catalysis for one-pot enzymatically modified isoquercitrin (EMIQ) conversion from rutin and sucrose using rationally designed gradient temperature control publication-title: Food Chemistry – volume: 139 start-page: 24 year: 2017 end-page: 39 ident: bb0390 article-title: Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols publication-title: Biochemical Pharmacology – volume: 37 start-page: 138 year: 2017 end-page: 146 ident: bb0225 article-title: Improving quercetin dissolution and bioaccessibility with reduced crystallite sizes through media milling technique publication-title: Journal of Functional Foods – volume: 65 year: 2021 ident: bb0090 article-title: Increasing post-digestive solubility of curcumin is the Most successful strategy to improve its Oral bioavailability: A randomized cross-over trial in healthy adults and in vitro bioaccessibility experiments publication-title: Molecular Nutrition & Food Research – volume: 57 start-page: 896 year: 2013 end-page: 905 ident: bb0110 article-title: Dietary fat increases quercetin bioavailability in overweight adults publication-title: Molecular Nutrition & Food Research – volume: 30 start-page: 11 year: 2020 end-page: 20 ident: bb0235 article-title: A review on structure, modifications and structure-activity relation of quercetin and its derivatives publication-title: Journal of Microbiology and Biotechnology – volume: 54 start-page: 13 year: 2006 end-page: 17 ident: bb0080 article-title: Bioavailability of quercetin from berries and the diet publication-title: Nutrition and Cancer-an International Journal – volume: 40 start-page: 554 year: 2019 end-page: 563 ident: bb0165 article-title: Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study publication-title: EBioMedicine – volume: 58 start-page: 3927 year: 2010 end-page: 3932 ident: bb0195 article-title: Bioavailability of various polyphenols from a diet containing moderate amounts of berries publication-title: Journal of Agricultural and Food Chemistry – volume: 458 year: 2024 ident: bb0420 article-title: The bioavailability, absorption, metabolism, and regulation of glucolipid metabolism disorders by quercetin and its important glycosides: A review publication-title: Food Chemistry – volume: 31 start-page: 569 year: 1999 end-page: 573 ident: bb0125 article-title: The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man publication-title: Free Radical Research – volume: 82 year: 2021 ident: bb0085 article-title: The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism publication-title: Journal of Functional Foods – volume: 80 start-page: H2597 year: 2015 end-page: H2602 ident: bb0175 article-title: Effect of processed onions on the plasma concentration of quercetin in rats and humans publication-title: Journal of Food Science – volume: 183 start-page: 30 year: 2015 end-page: 35 ident: bb0155 article-title: Determination of flavonol glycosides in green tea, oolong tea and black tea by UHPLC compared to HPLC publication-title: Food Chemistry – volume: 37 start-page: 138 year: 2017 ident: 10.1016/j.foodchem.2025.143630_bb0225 article-title: Improving quercetin dissolution and bioaccessibility with reduced crystallite sizes through media milling technique publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2017.07.047 – volume: 48 start-page: 410 year: 2018 ident: 10.1016/j.foodchem.2025.143630_bb0305 publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2018.07.035 – volume: 40 start-page: 1035 issue: 10 year: 2006 ident: 10.1016/j.foodchem.2025.143630_bb0150 article-title: The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man publication-title: Free Radical Research doi: 10.1080/10715760600771400 – volume: 139 start-page: 24 year: 2017 ident: 10.1016/j.foodchem.2025.143630_bb0390 article-title: Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols publication-title: Biochemical Pharmacology doi: 10.1016/j.bcp.2017.03.012 – volume: 22 issue: 13 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0330 article-title: Screening of human gut bacterial culture collection identifies species that biotransform quercetin into metabolites with anticancer properties. International journal of molecular publication-title: Science – volume: 7 start-page: 46825 issue: 50 year: 2022 ident: 10.1016/j.foodchem.2025.143630_bb0160 article-title: Enhanced bioavailability and pharmacokinetics of a natural self- emulsifying reversible hybrid-hydrogel system of quercetin: A randomized double-blinded comparative crossover study publication-title: ACS Omega doi: 10.1021/acsomega.2c05929 – volume: 92 start-page: 801 issue: 4 year: 2010 ident: 10.1016/j.foodchem.2025.143630_bb0300 article-title: Urinary metabolites as biomarkers of polyphenol intake in humans: A systematic review publication-title: The American Journal of Clinical Nutrition doi: 10.3945/ajcn.2010.29924 – volume: 69 start-page: 5907 issue: 21 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0365 article-title: Combination of alpha-Glycosyl-Isoquercitrin and soybean Fiber promotes quercetin bioavailability and glucagon-like Peptide-1 secretion and improves glucose homeostasis in rats fed a high-fat high-sucrose diet publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.1c01388 – volume: 56 start-page: 343 issue: 1 year: 2017 ident: 10.1016/j.foodchem.2025.143630_bb0035 article-title: Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans publication-title: European Journal of Nutrition doi: 10.1007/s00394-015-1084-x – volume: 16 issue: 1 year: 2024 ident: 10.1016/j.foodchem.2025.143630_bb0045 article-title: Flavonoid metabolites in serum and urine after the ingestion of selected tropical fruits publication-title: Nutrients doi: 10.3390/nu16010161 – volume: 360 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0230 article-title: Bioavailability of quercetin in zein-based colloidal particles-stabilized Pickering emulsions investigated by the in vitro digestion coupled with Caco-2 cell monolayer model publication-title: Food Chemistry doi: 10.1016/j.foodchem.2021.130152 – volume: 22 start-page: 217 issue: 3 year: 2003 ident: 10.1016/j.foodchem.2025.143630_bb0185 article-title: Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers publication-title: Journal of the American College of Nutrition doi: 10.1080/07315724.2003.10719296 – volume: 30 start-page: 11 issue: 1 year: 2020 ident: 10.1016/j.foodchem.2025.143630_bb0235 article-title: A review on structure, modifications and structure-activity relation of quercetin and its derivatives publication-title: Journal of Microbiology and Biotechnology doi: 10.4014/jmb.1907.07003 – volume: 31 start-page: 569 issue: 6 year: 1999 ident: 10.1016/j.foodchem.2025.143630_bb0125 article-title: The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man publication-title: Free Radical Research doi: 10.1080/10715769900301141 – volume: 88 start-page: 159 year: 2016 ident: 10.1016/j.foodchem.2025.143630_bb0310 article-title: Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources publication-title: Food Research International doi: 10.1016/j.foodres.2016.02.013 – volume: 44 start-page: 169 issue: 2 year: 2019 ident: 10.1016/j.foodchem.2025.143630_bb0320 article-title: Improved Oral absorption of quercetin from quercetin Phytosome®, a new delivery system based on food grade lecithin publication-title: European Journal of Drug Metabolism and Pharmacokinetics doi: 10.1007/s13318-018-0517-3 – volume: 47 start-page: 446 year: 2019 ident: 10.1016/j.foodchem.2025.143630_bb0120 article-title: Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease publication-title: EBioMedicine doi: 10.1016/j.ebiom.2019.08.069 – volume: 80 start-page: H2597 issue: 11 year: 2015 ident: 10.1016/j.foodchem.2025.143630_bb0175 article-title: Effect of processed onions on the plasma concentration of quercetin in rats and humans publication-title: Journal of Food Science doi: 10.1111/1750-3841.13079 – volume: 82 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0085 article-title: The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2021.104501 – volume: 463 issue: Pt 2 year: 2025 ident: 10.1016/j.foodchem.2025.143630_bb0405 article-title: The application of dietary fibre as microcapsule wall material in food processing publication-title: Food Chemistry – volume: 123 start-page: 182 issue: 2 year: 2020 ident: 10.1016/j.foodchem.2025.143630_bb0020 article-title: Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease publication-title: British Journal of Nutrition doi: 10.1017/S0007114519002137 – volume: 501 start-page: 91 issue: 1 year: 2010 ident: 10.1016/j.foodchem.2025.143630_bb0270 article-title: α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans publication-title: Archives of Biochemistry and Biophysics doi: 10.1016/j.abb.2010.06.036 – volume: 37 start-page: 1148 issue: 5 year: 2008 ident: 10.1016/j.foodchem.2025.143630_bb0295 article-title: Sensitivity of between-study heterogeneity in meta-analysis: Proposed metrics and empirical evaluation publication-title: International Journal of Epidemiology doi: 10.1093/ije/dyn065 – volume: 107 year: 2023 ident: 10.1016/j.foodchem.2025.143630_bb0105 article-title: Fiber consumption stimulates the activity of microbial bile salt hydrolases publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2023.105707 – volume: 57 start-page: 6 issue: 1 year: 2004 ident: 10.1016/j.foodchem.2025.143630_bb0245 article-title: Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications publication-title: British Journal of Clinical Pharmacology doi: 10.1046/j.1365-2125.2003.02007.x – volume: 86 start-page: 1921 issue: 10 year: 2020 ident: 10.1016/j.foodchem.2025.143630_bb0060 article-title: Prescribing medicines to older people-how to consider the impact of ageing on human organ and body functions publication-title: British Journal of Clinical Pharmacology doi: 10.1111/bcp.14094 – year: 2024 ident: 10.1016/j.foodchem.2025.143630_bb0200 article-title: Controlled lipid digestion in the development of functional and personalized foods for a tailored delivery of dietary fats publication-title: Food Chemistry – volume: 41 start-page: 492 issue: 5 year: 2001 ident: 10.1016/j.foodchem.2025.143630_bb0100 article-title: Pharmacokinetics and bioavailability of quercetin glycosides in humans publication-title: The Journal of Clinical Pharmacology doi: 10.1177/00912700122010366 – volume: 74 start-page: 331 issue: 3 year: 1997 ident: 10.1016/j.foodchem.2025.143630_bb0315 article-title: Analysis of the major Flavonol glycosides present in four varieties of onion (Allium cepa) and changes in composition resulting from autolysis publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/(SICI)1097-0010(199707)74:3<331::AID-JSFA806>3.0.CO;2-C – volume: 68 start-page: 60 issue: 1 year: 1998 ident: 10.1016/j.foodchem.2025.143630_bb0370 article-title: Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake publication-title: American Journal of Clinical Nutrition doi: 10.1093/ajcn/68.1.60 – volume: 96 start-page: 107 issue: 1 year: 2006 ident: 10.1016/j.foodchem.2025.143630_bb0265 article-title: Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions publication-title: British Journal of Nutrition doi: 10.1079/BJN20061809 – volume: 82 start-page: 2007 issue: 11 year: 2018 ident: 10.1016/j.foodchem.2025.143630_bb0240 article-title: Influence of long-term feeding of high-fat diet on quercetin and fat absorption from the small intestine in lymph duct-cannulated rats publication-title: Bioscience, Biotechnology, and Biochemistry doi: 10.1080/09168451.2018.1498726 – volume: 92 start-page: 2033 issue: 2 year: 2013 ident: 10.1016/j.foodchem.2025.143630_bb0210 article-title: Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability publication-title: Carbohydrate Polymers doi: 10.1016/j.carbpol.2012.11.073 – volume: 52 start-page: 935 issue: 4 year: 2004 ident: 10.1016/j.foodchem.2025.143630_bb0255 article-title: Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf030582e – volume: 113 start-page: 1531 issue: 10 year: 2015 ident: 10.1016/j.foodchem.2025.143630_bb0285 article-title: Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects publication-title: British Journal of Nutrition doi: 10.1017/S0007114515000537 – volume: 44 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0015 article-title: Physicochemical study of dietary fiber methylcellulose and human intestinal bile salt micellar aggregates publication-title: Colloid and Interface Science Communications doi: 10.1016/j.colcom.2021.100493 – volume: 131 start-page: 745 issue: 3 year: 2001 ident: 10.1016/j.foodchem.2025.143630_bb0375 article-title: Red wine is a poor source of bioavailable flavonols in men publication-title: The Journal of Nutrition doi: 10.1093/jn/131.3.745 – volume: 119 year: 2023 ident: 10.1016/j.foodchem.2025.143630_bb0040 article-title: Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review publication-title: Phytomedicine doi: 10.1016/j.phymed.2023.154979 – volume: 126 start-page: 476 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0290 article-title: Waste streams in onion production: Bioactive compounds, quercetin and use of antimicrobial and antioxidative properties publication-title: Waste Management doi: 10.1016/j.wasman.2021.03.033 – volume: 60 start-page: 3874 issue: 15 year: 2012 ident: 10.1016/j.foodchem.2025.143630_bb0205 article-title: Pharmacokinetics of quercetin absorption from apples and onions in healthy humans publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf3001857 – volume: 88 start-page: 140 issue: Pt A year: 2016 ident: 10.1016/j.foodchem.2025.143630_bb0250 article-title: Boosting the bioavailability of hydrophobic nutrients, vitamins, and nutraceuticals in natural products using excipient emulsions publication-title: Food Research International doi: 10.1016/j.foodres.2015.11.017 – volume: 458 year: 2024 ident: 10.1016/j.foodchem.2025.143630_bb0420 article-title: The bioavailability, absorption, metabolism, and regulation of glucolipid metabolism disorders by quercetin and its important glycosides: A review publication-title: Food Chemistry doi: 10.1016/j.foodchem.2024.140262 – volume: 65 start-page: 1199 issue: 7 year: 2003 ident: 10.1016/j.foodchem.2025.143630_bb0055 article-title: Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter publication-title: Biochemical Pharmacology doi: 10.1016/S0006-2952(03)00039-X – volume: 34 start-page: 297 issue: 3 year: 2001 ident: 10.1016/j.foodchem.2025.143630_bb0135 article-title: Addition of milk does not affect the absorption of flavonols from tea in man publication-title: Free Radical Research doi: 10.1080/10715760100300261 – volume: 3 year: 2023 ident: 10.1016/j.foodchem.2025.143630_bb0340 article-title: Shellac/caseinate as a composite nanocarrier for improved bioavailability of quercetin publication-title: Food Hydrocolloids for Health doi: 10.1016/j.fhfh.2022.100113 – volume: 149 year: 2024 ident: 10.1016/j.foodchem.2025.143630_bb0360 article-title: Enhancing the bioavailability of quercetin via the construction of carboxymethylated curdlan/quercetin nanocomplex publication-title: Food Hydrocolloids doi: 10.1016/j.foodhyd.2023.109502 – volume: 85 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0170 article-title: Bioavailability of dietary isoquercitrin-gamma-cyclodextrin molecular inclusion complex in Sprague-Dawley rats and healthy humans publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2021.104663 – volume: 98 start-page: 690 issue: 4 year: 2015 ident: 10.1016/j.foodchem.2025.143630_bb0025 article-title: Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites publication-title: Biochemical Pharmacology doi: 10.1016/j.bcp.2015.09.022 – volume: 57 start-page: 896 issue: 5 year: 2013 ident: 10.1016/j.foodchem.2025.143630_bb0110 article-title: Dietary fat increases quercetin bioavailability in overweight adults publication-title: Molecular Nutrition & Food Research doi: 10.1002/mnfr.201200619 – volume: 77 start-page: H231 issue: 11 year: 2012 ident: 10.1016/j.foodchem.2025.143630_bb0180 article-title: Comparison of quercetin pharmacokinetics following oral supplementation in humans publication-title: Journal of Food Science doi: 10.1111/j.1750-3841.2012.02934.x – volume: 58 start-page: 3927 issue: 7 year: 2010 ident: 10.1016/j.foodchem.2025.143630_bb0195 article-title: Bioavailability of various polyphenols from a diet containing moderate amounts of berries publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9024823 – volume: 57 start-page: 280 issue: 100 year: 2014 ident: 10.1016/j.foodchem.2025.143630_bb0275 article-title: Animal versus human oral drug bioavailability: Do they correlate? publication-title: European Journal of Pharmaceutical Sciences doi: 10.1016/j.ejps.2013.08.018 – volume: 183 start-page: 30 year: 2015 ident: 10.1016/j.foodchem.2025.143630_bb0155 article-title: Determination of flavonol glycosides in green tea, oolong tea and black tea by UHPLC compared to HPLC publication-title: Food Chemistry doi: 10.1016/j.foodchem.2015.03.024 – volume: 147 year: 2020 ident: 10.1016/j.foodchem.2025.143630_bb0215 article-title: Analysis of polyphenols in apple pomace: A comparative study of different extraction and hydrolysis procedures publication-title: Industrial Crops and Products doi: 10.1016/j.indcrop.2020.112250 – volume: 40 start-page: 554 year: 2019 ident: 10.1016/j.foodchem.2025.143630_bb0165 article-title: Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study publication-title: EBioMedicine doi: 10.1016/j.ebiom.2018.12.052 – volume: 213 start-page: 112 year: 2019 ident: 10.1016/j.foodchem.2025.143630_bb0190 article-title: Increased renal cellular senescence in murine high-fat diet: Effect of the senolytic drug quercetin publication-title: Translational Research doi: 10.1016/j.trsl.2019.07.005 – volume: 138 start-page: 885 issue: 5 year: 2008 ident: 10.1016/j.foodchem.2025.143630_bb0385 article-title: Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides publication-title: The Journal of Nutrition doi: 10.1093/jn/138.5.885 – volume: 16 start-page: 6983 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0010 article-title: Phytosomes as innovative delivery Systems for Phytochemicals: A comprehensive review of literature publication-title: International Journal of Nanomedicine doi: 10.2147/IJN.S318416 – volume: 16 start-page: 548 issue: 3 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0145 article-title: Apple Peel and flesh contain pro-neurogenic compounds publication-title: Stem Cell Reports doi: 10.1016/j.stemcr.2021.01.005 – volume: 355 year: 2016 ident: 10.1016/j.foodchem.2025.143630_bb0350 article-title: ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions publication-title: The BMJ – volume: 77 start-page: 4799 issue: 23 year: 2020 ident: 10.1016/j.foodchem.2025.143630_bb0075 article-title: A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine : “a gut feeling” publication-title: Cellular and Molecular Life Sciences doi: 10.1007/s00018-020-03564-1 – volume: 418 start-page: 152 issue: 1–2 year: 1997 ident: 10.1016/j.foodchem.2025.143630_bb0140 article-title: Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man publication-title: Federation of European Biochemical Societies letters doi: 10.1016/S0014-5793(97)01367-7 – volume: 12 start-page: 3420 issue: 8 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0410 article-title: Encapsulation of lipophilic polyphenols in plant-based nanoemulsions: Impact of carrier oil on lipid digestion and curcumin, resveratrol and quercetin bioaccessibility publication-title: Food & Function doi: 10.1039/D1FO00275A – volume: 54 start-page: 13 issue: 1 year: 2006 ident: 10.1016/j.foodchem.2025.143630_bb0080 article-title: Bioavailability of quercetin from berries and the diet publication-title: Nutrition and Cancer-an International Journal doi: 10.1207/s15327914nc5401_3 – volume: 114 start-page: 139 issue: 1–2 year: 1997 ident: 10.1016/j.foodchem.2025.143630_bb0130 article-title: Bioavailability of the dietary antioxidant flavonol quercetin in man publication-title: Cancer Letters doi: 10.1016/S0304-3835(97)04644-2 – volume: 339 year: 2009 ident: 10.1016/j.foodchem.2025.143630_bb0260 article-title: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement publication-title: The BMJ doi: 10.1136/bmj.b2535 – volume: 36 start-page: 79 issue: 1 year: 2003 ident: 10.1016/j.foodchem.2025.143630_bb0095 article-title: Absorption of three wine-related polyphenols in three different matrices by healthy subjects publication-title: Clinical Biochemistry doi: 10.1016/S0009-9120(02)00397-1 – volume: 107 start-page: 539 issue: 4 year: 2012 ident: 10.1016/j.foodchem.2025.143630_bb0070 article-title: Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules publication-title: British Journal of Nutrition doi: 10.1017/S0007114511003242 – volume: 43 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0415 article-title: Potential applications and preliminary mechanism of action of dietary polyphenols against hyperuricemia: A review publication-title: Food Bioscience doi: 10.1016/j.fbio.2021.101297 – volume: 44 start-page: 2033 issue: 5 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0050 article-title: Anti-inflammatory and Hepatoprotective effects of quercetin in an experimental model of rheumatoid arthritis publication-title: Inflammation doi: 10.1007/s10753-021-01479-y – volume: 187 start-page: 135 year: 2015 ident: 10.1016/j.foodchem.2025.143630_bb0115 article-title: Human exposure modelling of quercetin in onions (Allium cepa L.) following thermal processing publication-title: Food Chemistry doi: 10.1016/j.foodchem.2015.04.035 – volume: 6 start-page: 1443 issue: 5 year: 2015 ident: 10.1016/j.foodchem.2025.143630_bb0335 article-title: Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: A randomized, single-blinded, cross-over study publication-title: Food & Function doi: 10.1039/C5FO00155B – volume: 366 year: 2019 ident: 10.1016/j.foodchem.2025.143630_bb0355 article-title: RoB 2: A revised tool for assessing risk of bias in randomised trials publication-title: The BMJ – volume: 50 start-page: 243 issue: 2 year: 1998 ident: 10.1016/j.foodchem.2025.143630_bb0030 article-title: Extensive binding of the bioflavonoid quercetin to human plasma proteins publication-title: Journal of Pharmacy and Pharmacology doi: 10.1111/j.2042-7158.1998.tb06183.x – volume: 58 start-page: 310 issue: 2 year: 2014 ident: 10.1016/j.foodchem.2025.143630_bb0280 article-title: Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans publication-title: Molecular Nutrition & Food Research doi: 10.1002/mnfr.201300234 – volume: 107 start-page: 539 issue: 4 year: 2012 ident: 10.1016/j.foodchem.2025.143630_bb0065 article-title: Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules publication-title: British Journal of Nutrition doi: 10.1017/S0007114511003242 – volume: 115 start-page: 222 year: 2012 ident: 10.1016/j.foodchem.2025.143630_bb0380 article-title: Preparatory production of quercetin-3-beta-D-glucopyranoside using alkali-tolerant thermostable alpha-L-rhamnosidase from aspergillus terreus publication-title: Bioresource Technology doi: 10.1016/j.biortech.2011.08.029 – volume: 62 year: 2024 ident: 10.1016/j.foodchem.2025.143630_bb0220 article-title: A modified self-micro emulsifying liposome for bioavailability enhancement of quercetin and its biological effects publication-title: Food Bioscience doi: 10.1016/j.fbio.2024.105352 – volume: 27 start-page: 141 issue: 4 year: 1995 ident: 10.1016/j.foodchem.2025.143630_bb0395 article-title: Comparative pharmacokinetics and bioavailability of flavonoid glycosides of Ginkgo biloba after a single oral administration of three formulations to healthy volunteers publication-title: Materia Medica Polona – volume: 13 start-page: 981 year: 2022 ident: 10.1016/j.foodchem.2025.143630_bb0005 article-title: Enhancing the bioavailability of quercetin by concomitant administration with enzyme inhibitor publication-title: Journal of Pharmaceutical Negative Results doi: 10.47750/pnr.2022.13.S06.131 – volume: 65 issue: 24 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0090 article-title: Increasing post-digestive solubility of curcumin is the Most successful strategy to improve its Oral bioavailability: A randomized cross-over trial in healthy adults and in vitro bioaccessibility experiments publication-title: Molecular Nutrition & Food Research doi: 10.1002/mnfr.202100613 – volume: 166 start-page: 10 year: 2021 ident: 10.1016/j.foodchem.2025.143630_bb0345 article-title: The role of quercetin in plants publication-title: Plant Physiology and Biochemistry doi: 10.1016/j.plaphy.2021.05.023 – volume: 457 year: 2024 ident: 10.1016/j.foodchem.2025.143630_bb0400 article-title: A novel cascade catalysis for one-pot enzymatically modified isoquercitrin (EMIQ) conversion from rutin and sucrose using rationally designed gradient temperature control publication-title: Food Chemistry doi: 10.1016/j.foodchem.2024.140163 – volume: 5 start-page: 228 year: 2022 ident: 10.1016/j.foodchem.2025.143630_bb0325 article-title: Trust your gut: Bioavailability and bioaccessibility of dietary compounds publication-title: Current Research in Food Science doi: 10.1016/j.crfs.2022.01.002
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SubjectTerms	bioactive properties bioavailability Biological Availability blood chemical structure Clinical Trials as Topic Dietary Supplements - analysis Emulsification Encapsulation fenugreek Flavonoid food chemistry food matrix Food matrix interactions galactomannans Humans lecithins meta-analysis Polyphenols quercetin Quercetin - administration & dosage Quercetin - analysis Quercetin - pharmacokinetics Solid dispersion systematic review urine
Title	Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies
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