Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons

Cilia play diverse roles in vertebrate and invertebrate sensory neurons. We show that a mutation of the zebrafish oval (ovl) locus affects a component of the ciliary transport (IFT) mechanism, the IFT88 polypeptide. In mutant retina, cilia are generated but not maintained, producing the absence of p...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 42; H. 5; S. 703
Hauptverfasser:	Tsujikawa, Motokazu, Malicki, Jarema
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 10.06.2004
Schlagworte:	Algal Proteins - physiology Animals Animals, Genetically Modified Biological Transport - genetics Biological Transport - physiology Blotting, Western - methods Body Patterning - genetics Body Patterning - physiology Carrier Proteins - genetics Cell Differentiation - genetics Cell Differentiation - physiology Cell Survival - genetics Cell Survival - physiology Chromosome Mapping Cilia - metabolism Cloning, Molecular - methods Embryo, Mammalian Embryo, Nonmammalian Flagella - metabolism Gene Expression Regulation, Developmental Green Fluorescent Proteins Humans Immunohistochemistry - methods In Situ Hybridization - methods In Situ Nick-End Labeling - methods Luminescent Proteins - metabolism Mice Microinjections Microscopy, Electron Molecular Sequence Data Mutation Neurons, Afferent - cytology Neurons, Afferent - ultrastructure Phalloidine Phenotype Photic Stimulation Plant Proteins Propidium Protozoan Proteins - genetics Protozoan Proteins - physiology Retina - metabolism Retina - ultrastructure Retinal Cone Photoreceptor Cells - metabolism Retinal Rod Photoreceptor Cells - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis Rod Opsins - metabolism Sequence Analysis, DNA Sequence Homology, Amino Acid Tubulin - metabolism Zebrafish
ISSN:	0896-6273
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