Some characteristics of a retrovirus isolated from transformed bovine cells

A novel retrovirus has been isolated from bovine cells transformed after cocultivation with leukocytes from an animal suffering from sheep-associated bovine malignant catarrhal fever. Morphologically and in its morphogenesis the virus resembles the type D Mason-Pfizer monkey virus (MPMV) as well as...

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Vydáno v:Virology (New York, N.Y.) Ročník 171; číslo 2; s. 394
Hlavní autoři: York, D F, Williamson, A, Barnard, B J, Verwoerd, D W
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.1989
Témata:
Animals
Antibodies, Viral - immunology
Blotting, Western
Cattle - microbiology
Cell Transformation, Viral
Cells, Cultured
Leukocytes - microbiology
Mice
Mice, Nude
Molecular Weight
Neoplasms, Experimental - microbiology
Neoplasms, Experimental - pathology
Retroviridae - immunology
Retroviridae - isolation & purification
Viral Proteins - analysis
ISSN:0042-6822
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Shrnutí:A novel retrovirus has been isolated from bovine cells transformed after cocultivation with leukocytes from an animal suffering from sheep-associated bovine malignant catarrhal fever. Morphologically and in its morphogenesis the virus resembles the type D Mason-Pfizer monkey virus (MPMV) as well as the ovine jaagsiekte retrovirus (JSRV). It is also serologically related to these two viruses, whereas a relationship to other known bovine retroviruses was not detected. However, its density of 1.16 g/ml in sucrose and the preference of its reverse transcriptase for manganese ions are closer to the characteristics of type C retroviruses. Unsuccessful attempts at transmission suggest that the virus may be defective in some function affecting its infectivity.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0042-6822
DOI:10.1016/0042-6822(89)90607-7