Examining relationships between the Danish Composite Deprivation Index and risk of developing schizophrenia: A national multilevel analysis

Few population-based multilevel analyses examining individual- and neighborhood-level risk factors for schizophrenia have been conducted. A study cohort of all persons born in Denmark from 1990 to 1999 was followed for diagnosis with schizophrenia. Follow-up was initiated at 10th birthday and termin...

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Veröffentlicht in:Schizophrenia research Jg. 285; S. 52 - 59
Hauptverfasser: Horsdal, Henriette T., Jensen, Anja S., Antonsen, Sussie, Pedersen, Marianne G., Trabjerg, Betina B., Thompson, Wesley K., Fan, Chun C., Sabel, Clive E., Agerbo, Esben, Pedersen, Carsten B., Webb, Roger T.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.11.2025
Schlagworte:
Adolescent
Adult
Cohort Studies
Crime - statistics & numerical data
Denmark - epidemiology
Deprivation
Educational Status
Employment - statistics & numerical data
Epidemiology
Female
Humans
Male
Middle Aged
Multilevel Analysis
Neighborhood Characteristics - statistics & numerical data
Psychiatric/Mental Health
Registries
Residence Characteristics - statistics & numerical data
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Social Deprivation
Young Adult
Denmark
Schizophrenia
Deprivation
Multilevel analysis
Epidemiology
Risk factors
ISSN:0920-9964, 1573-2509, 1573-2509
Online-Zugang:Volltext
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Zusammenfassung:Few population-based multilevel analyses examining individual- and neighborhood-level risk factors for schizophrenia have been conducted. A study cohort of all persons born in Denmark from 1990 to 1999 was followed for diagnosis with schizophrenia. Follow-up was initiated at 10th birthday and terminated at death, emigration, incident diagnosis, or 31st December 2018, whichever came first. A Danish Composite Deprivation Index was derived using 10-year weighted average neighborhood-level indicators in 1990–1999 categorized into five domains: Income; Employment; Education, Skills & Training; Health & Disability; and Crime. By fitting multilevel log-linear Poisson regression models, neighborhood-level deprivation indicators were examined with and without adjustment for individual-level covariates. Four neighborhood-level deprivation domains, Employment, Education, Skills & Training, Health & Disability, and Crime, as well as the Danish Composite Deprivation Index (adjusted IRR 1.14; 95 % credibility interval 1.10–1.17), were associated with elevated risk independent of individual-level deprivation measures. The specific neighborhood-level indicators linked with the highest adjusted elevations in risk were: Proportion of inhabitants aged 18–22 years who did not complete primary school before age 18 (adjusted IRR 1.23; 1.20–1.27); Proportion of inhabitants convicted for any violent crime (adjusted IRR 1.19; 1.16–1.23); and Proportion of inhabitants convicted for any crime resulting in a custodial sentence (adjusted IRR 1.15; 1.12–1.18). This novel population-based multilevel analysis has evidenced the independent associations of neighborhood-level deprivation indicators on schizophrenia risk elevation. Replication is needed in other populations to inform the refinement of preventive strategies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0920-9964
1573-2509
1573-2509
DOI:10.1016/j.schres.2025.09.001