The Apolipoprotein L Gene Cluster Has Emerged Recently in Evolution and Is Expressed in Human Vascular Tissue

We previously isolated APOL3 (CG12-1) cDNA and now describe the isolation of APOL1 and APOL2 cDNA from an activated endothelial cell cDNA library and show their endothelialspecific expression in human vascular tissue. APOL1–APOL4 are clustered on human chromosome 22q13.1, as a result of tandem gene...

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Bibliographic Details
Published in:	Genomics (San Diego, Calif.) Vol. 79; no. 4; pp. 539 - 546
Main Authors:	Monajemi, Houshang, Fontijn, Ruud D., Pannekoek, Hans, Horrevoets, Anton J.G.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01.04.2002 Elsevier
Subjects:	Amino Acid Sequence Animals APOL1 gene APOL2 gene APOL3 gene APOL4 gene Apolipoprotein L Apolipoprotein L1 Apolipoproteins - genetics Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Vessels - metabolism Cardiology. Vascular system chromosome 22 Chromosomes, Human, Pair 22 - genetics Evolution, Molecular Gene Expression Profiling Haplorhini - genetics Humans Lipoproteins, HDL - genetics Medical sciences Molecular Sequence Data Multigene Family Organ Specificity Sequence Alignment Sequence Analysis, DNA atherosclerosis endothelial cells apolipoprotein L evolution vascular wall gene cluster mouse lipid metabolism duplication Human Gene cluster Endothelial cell Cardiovascular disease Chromosome G22 Apolipoprotein Gene expression Tandemly repeated sequence Vascular disease Gene Atherosclerosis Evolution Gene duplication Vascular wall
ISSN:	0888-7543, 1089-8646
Online Access:	Get full text
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