Antibacterial Activity of Cold Atmospheric Pressure Argon Plasma against 78 Genetically Different (mecA, luk-P, agr or Capsular Polysaccharide Type) Staphylococcus aureus Strains

Previous studies on the antimicrobial activity of cold atmospheric pressure argon plasma showed varying effects against mecA + or mecA - Staphylococcus aureus strains. This observation may have important clinical and epidemiological implications. Here, the antibacterial activity of argon plasma was...

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Veröffentlicht in:Skin pharmacology and physiology Jg. 29; H. 2; S. 83 - 91
Hauptverfasser: Matthes, Rutger, Lührman, Anne, Holtfreter, Silva, Kolata, Julia, Radke, Dörte, Hübner, Nils-Olaf, Assadian, Ojan, Kramer, Axel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel, Switzerland S. Karger AG 01.01.2016
Schlagworte:
Anti-Bacterial Agents - administration & dosage
Argon
Argon - administration & dosage
Atmospheric Pressure
Bacterial Proteins
Care and treatment
Cold Temperature - adverse effects
Development and progression
Health aspects
High temperature plasmas
Humans
Original Paper
Peroxidases
Plasma (Ionized gases)
Polysaccharides, Bacterial - antagonists & inhibitors
Polysaccharides, Bacterial - genetics
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
United Kingdom
Methicillin-resistant S. aureus
Tolerability
Antibacterial efficacy
Virulence
Staphylococcus aureus
Cold atmospheric pressure plasma
ISSN:1660-5527, 1660-5535
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Zusammenfassung:Previous studies on the antimicrobial activity of cold atmospheric pressure argon plasma showed varying effects against mecA + or mecA - Staphylococcus aureus strains. This observation may have important clinical and epidemiological implications. Here, the antibacterial activity of argon plasma was investigated against 78 genetically different S. aureus strains, stratified by mecA, luk-P, agr1-4, or the cell wall capsule polysaccharide types 5 and 8. kINPen09® served as the plasma source for all experiments. On agar plates, mecA + luk-P - S. aureus strains showed a decreased susceptibility against plasma compared to other S. aureus strains. This study underlines the high complexity of microbial defence against antimicrobial treatment and confirms a previously reported strain-dependent susceptibility of S. aureus to plasma treatment.
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ISSN:1660-5527
1660-5535
DOI:10.1159/000443210