Severe long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the vervet monkey ( Cercopithecus aethiops sabaeus)

The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces parkinsonian neurochemical and functional deficits in human and non-human primates. The utility of MPTP-induced parkinsonism in monkeys as an animal model of Parkinson's disease would be greater if it produced a persist...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 81; no. 3; pp. 745 - 755
Main Authors:	Taylor, J.R, Elsworth, J.D, Roth, R.H, Sladek, J.R, Redmond, D.E
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01.12.1997 Elsevier
Subjects:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Behavior, Animal - physiology behaviour Biological and medical sciences Cercopithecus aethiops Chronic Disease Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Male Medical sciences monkey Movement MPTP Neurology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - physiopathology Parkinson Disease, Secondary - psychology Parkinson's disease Severity of Illness Index Time Factors DA, dopamine BASE, baseline PDRS, Parkinson's disease rating scales 6-OHDA, 6-hydroxydopamine monkey Parkinson's disease TH, tyrosine hydroxylase ANOVA, analysis of variance MO, month behaviour MPTP MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animal model Nervous system diseases Monkey Cercopithecus aethiops Parkinson disease Cerebral disorder Vertebrata Mammalia Central nervous system disease Neurotoxin Primates Simioidea Degenerative disease Extrapyramidal syndrome
ISSN:	0306-4522, 1873-7544
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!