Sepsis, Coagulation, and Antithrombin: Old Lessons and New Insights
ABSTRACT Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the most important mechanisms contributing to the activation of coagulation in sepsis is the downregulation of physiologic anticoagulant...
Uloženo v:
| Vydáno v: | Seminars in thrombosis and hemostasis Ročník 34; číslo 8; s. 742 - 746 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.11.2008
|
| Témata: | |
| ISSN: | 0094-6176, 1098-9064, 1098-9064 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | ABSTRACT
Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the most important mechanisms contributing to the activation of coagulation in sepsis is the downregulation of physiologic anticoagulant systems, such as the antithrombin pathway. More than 20 years ago, Eberhard Mammen already hypothesized that coagulation activation and antithrombin were important factors in patients with sepsis. Abundant experimental and clinical studies have supported that notion in recent years. The better understanding of the pathogenesis of coagulation activation and the role of natural anticoagulants in sepsis has led to the development of anticoagulant factor concentrates, such as antithrombin concentrate. Clinical studies indicate that these interventions may have a role in the (supportive) treatment of patients with sepsis, mostly based on surrogate outcomes, but ongoing studies will have to confirm a beneficial effect in reducing mortality. |
|---|---|
| AbstractList | Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the most important mechanisms contributing to the activation of coagulation in sepsis is the downregulation of physiologic anticoagulant systems, such as the antithrombin pathway. More than 20 years ago, Eberhard Mammen already hypothesized that coagulation activation and antithrombin were important factors in patients with sepsis. Abundant experimental and clinical studies have supported that notion in recent years. The better understanding of the pathogenesis of coagulation activation and the role of natural anticoagulants in sepsis has led to the development of anticoagulant factor concentrates, such as antithrombin concentrate. Clinical studies indicate that these interventions may have a role in the (supportive) treatment of patients with sepsis, mostly based on surrogate outcomes, but ongoing studies will have to confirm a beneficial effect in reducing mortality.Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the most important mechanisms contributing to the activation of coagulation in sepsis is the downregulation of physiologic anticoagulant systems, such as the antithrombin pathway. More than 20 years ago, Eberhard Mammen already hypothesized that coagulation activation and antithrombin were important factors in patients with sepsis. Abundant experimental and clinical studies have supported that notion in recent years. The better understanding of the pathogenesis of coagulation activation and the role of natural anticoagulants in sepsis has led to the development of anticoagulant factor concentrates, such as antithrombin concentrate. Clinical studies indicate that these interventions may have a role in the (supportive) treatment of patients with sepsis, mostly based on surrogate outcomes, but ongoing studies will have to confirm a beneficial effect in reducing mortality. Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the most important mechanisms contributing to the activation of coagulation in sepsis is the downregulation of physiologic anticoagulant systems, such as the antithrombin pathway. More than 20 years ago, Eberhard Mammen already hypothesized that coagulation activation and antithrombin were important factors in patients with sepsis. Abundant experimental and clinical studies have supported that notion in recent years. The better understanding of the pathogenesis of coagulation activation and the role of natural anticoagulants in sepsis has led to the development of anticoagulant factor concentrates, such as antithrombin concentrate. Clinical studies indicate that these interventions may have a role in the (supportive) treatment of patients with sepsis, mostly based on surrogate outcomes, but ongoing studies will have to confirm a beneficial effect in reducing mortality. ABSTRACT Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the most important mechanisms contributing to the activation of coagulation in sepsis is the downregulation of physiologic anticoagulant systems, such as the antithrombin pathway. More than 20 years ago, Eberhard Mammen already hypothesized that coagulation activation and antithrombin were important factors in patients with sepsis. Abundant experimental and clinical studies have supported that notion in recent years. The better understanding of the pathogenesis of coagulation activation and the role of natural anticoagulants in sepsis has led to the development of anticoagulant factor concentrates, such as antithrombin concentrate. Clinical studies indicate that these interventions may have a role in the (supportive) treatment of patients with sepsis, mostly based on surrogate outcomes, but ongoing studies will have to confirm a beneficial effect in reducing mortality. |
| Author | Schouten, Marcel van der Poll, Tom Levi, Marcel |
| Author_xml | – sequence: 1 givenname: Marcel surname: Levi fullname: Levi, Marcel organization: Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands – sequence: 2 givenname: Marcel surname: Schouten fullname: Schouten, Marcel organization: Center for Infection and Inflammation Research (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands – sequence: 3 givenname: Tom surname: van der Poll fullname: van der Poll, Tom organization: Center for Infection and Inflammation Research (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19214912$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kDtPwzAUhS1URB-wMqJMTDX4urYTs1UVj0oVHYDZcmK7dZXYJU6E-Pe0UKY7nE9H535jNAgxWISugdwB4fw-YUKoxACMUy7O0AiILLAkgg3QiBDJsIBcDNE4pR0hwApCL9AQJAUmgY7Q4s3uk0_TbBH1pq9152OYZjqYbB46323b2JQ-PGTr2mQrm1IM6Td9tV_ZMiS_2XbpEp07XSd7dboT9PH0-L54wav183IxX-GKibzDrNSaz8o8Z4QWwCHX4ARIU3LnKDXUaMOIFM4UleaaGlMQl1eEFczKyjk7m6Dbv959Gz97mzrV-FTZutbBxj4pIURBQcABvDmBfdlYo_atb3T7rf7fPgD4D-i23jZW7WLfhsN0BUQdtaqkjlrVSevsB3NGaKg |
| CitedBy_id | crossref_primary_10_1186_s40560_021_00555_7 crossref_primary_10_1111_j_1752_8062_2011_00351_x crossref_primary_10_1155_2016_4054806 crossref_primary_10_1007_s00281_011_0280_x crossref_primary_10_1016_j_amjmed_2010_10_018 crossref_primary_10_1592_phco_30_10_994 crossref_primary_10_1136_vr_105283 crossref_primary_10_1186_s12959_023_00556_6 crossref_primary_10_1186_s40635_015_0072_z crossref_primary_10_1016_j_vascn_2011_09_001 crossref_primary_10_1186_cc12716 crossref_primary_10_1007_s11739_014_1176_2 crossref_primary_10_1016_j_jevs_2014_08_005 crossref_primary_10_1186_s12959_025_00747_3 crossref_primary_10_1002_ams2_659 crossref_primary_10_4196_kjpp_2016_20_1_83 crossref_primary_10_1016_j_arcmed_2021_07_003 crossref_primary_10_4196_kjpp_2017_21_5_495 crossref_primary_10_1111_j_1538_7836_2010_03891_x crossref_primary_10_3390_jcm9092875 crossref_primary_10_12688_f1000research_6709_1 crossref_primary_10_4187_respcare_01531 crossref_primary_10_12688_f1000research_6709_2 crossref_primary_10_1016_j_thromres_2014_02_014 crossref_primary_10_1371_journal_pone_0170334 crossref_primary_10_1007_s12272_011_0318_6 crossref_primary_10_1186_1479_5876_9_25 crossref_primary_10_1016_j_vascn_2012_11_003 crossref_primary_10_1038_s41598_023_49855_y crossref_primary_10_3390_ijms232012474 |
| ContentType | Journal Article |
| Copyright | Thieme Medical Publishers |
| Copyright_xml | – notice: Thieme Medical Publishers |
| DBID | 0U6 CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1055/s-0029-1145256 |
| DatabaseName | Thieme Connect Journals Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: 0U6 name: Thieme Connect Journals Open Access url: http://open.thieme.com sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1098-9064 |
| EndPage | 746 |
| ExternalDocumentID | 19214912 10_1055_s_0029_1145256 |
| Genre | Journal Article Review |
| GroupedDBID | --- .GJ 0R~ 0U6 123 1UC 4.4 53G 5RE 5~~ AAIWL AAKAS AAQQT ABJNI ABOCM ABZLV ACGFO ACGFS ADZCM AENEX AEVEF AHRAW AHRSK AIVKU AJGCD AKJTW ALMA_UNASSIGNED_HOLDINGS BPGNG C45 CAG COF CS3 DU5 EBS EJD EXEOM F5P H13 IY8 J5H N9A O9- OVD P2P Q3R QTC RIG ROL RTC TEORI TWZ UDS YFH ZGI ZXP ACNUY AGCGI CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c467t-4baa53b7740281517a1f619db5ff22d2dad4096fd8ca5a2dd80f7c0484e9cffe3 |
| IEDL.DBID | 0U6 |
| ISICitedReferencesCount | 40 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000263072500008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0094-6176 1098-9064 |
| IngestDate | Thu Jul 10 19:32:49 EDT 2025 Mon Jul 21 05:23:59 EDT 2025 Sun Nov 24 15:09:11 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | antithrombin Sepsis thrombosis coagulation |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c467t-4baa53b7740281517a1f619db5ff22d2dad4096fd8ca5a2dd80f7c0484e9cffe3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | http://dx.doi.org/10.1055/s-0029-1145256 |
| PMID | 19214912 |
| PQID | 66682161 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_66682161 pubmed_primary_19214912 thieme_journals_10_1055_s_0029_1145256 |
| PublicationCentury | 2000 |
| PublicationDate | 2008-11-01 |
| PublicationDateYYYYMMDD | 2008-11-01 |
| PublicationDate_xml | – month: 11 year: 2008 text: 2008-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Seminars in thrombosis and hemostasis |
| PublicationTitleAlternate | Semin Thromb Hemost |
| PublicationYear | 2008 |
| SSID | ssj0014802 |
| Score | 2.0793922 |
| SecondaryResourceType | review_article |
| Snippet | ABSTRACT
Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation.... Current insights in the pathogenesis of multiple organ dysfunction in patients with sepsis point to a pivotal role of inflammation and coagulation. One of the... |
| SourceID | proquest pubmed thieme |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 742 |
| SubjectTerms | Anticoagulants - therapeutic use Antithrombins - physiology Antithrombins - therapeutic use Blood Coagulation - physiology Fibrinolytic Agents - therapeutic use Humans Sepsis - blood Sepsis - drug therapy |
| Title | Sepsis, Coagulation, and Antithrombin: Old Lessons and New Insights |
| URI | http://dx.doi.org/10.1055/s-0029-1145256 https://www.ncbi.nlm.nih.gov/pubmed/19214912 https://www.proquest.com/docview/66682161 |
| Volume | 34 |
| WOSCitedRecordID | wos000263072500008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1JS8NAFB60inhxX-qag3hqsJ3MJDPeSrEotLWghd6GySy2YJPSaf39vixVUQ-9DCELhJe3fC_fvPcQumkQrThhxMfcSp-YIPA5IdYPtGGaE82typu4dqJejw2HvP_9v-M3g0_pnfPzLRqA2ymE53W0gUFLMxOsD8IvvoCwetEXnJOs6C1ctmf88_x_QBIO5qOxmZgfkaW9u_o77aGdEj16zeJz76M1kxygrW7Jjx-i1ouZurGrea1UvpWDuWqeTLTXzMpxR7N0Apnwvff8rr0O-DhQufwquDrvKXFZou6O0KD98Np69MsxCb4CLzf3SSwlDWLAcYAVIIBHsmEhLdIxtRZjjbXUkMSFVjMlqcRas7qNFFguMVxZa4JjVEnSxJwiD-ABnGIKDDUmMqRSRsqGOA6yaRwhDaroeik9AWqYcQsyMenCCciCGAb0WEUnhVDFtOiWIbKGa4Q3cBXdFlIWpZU4kRPglAonMnGKUpxnq954jrbz3Rt5ZeAFqsxnC3OJNtXHfOxmV7mCwBoNGay9fvcTtcCx-A |
| linkProvider | Thieme |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fT9swED4NmBgvsME2OjbIA-IJq21ip_HeULWqFaWbRCvxZjn-QSvRtKpT_n7OiTshwQMPvEVOLFmfLufvdHffAZy3qVacZpTE3EpCTZIQTqkliTaZ5lRzqyoR12FnNMru7vi_0B7tQlllOZ2ZuSHKV3qo0pdaLGv1U9c0AWHXnJbzhzCnljUdqco4kNszvMK3YIf5CRJo3a1J-j-nQLNWrR3OqW-MSzcSji_2v0Y28aE-1rPbp3fwvuf-DPuBhUZXtdl8gQ-mOITdm5BnP4LurVm6mbuMugt5HwZ8XUay0NGVb-udrhZzjKh_R38fdDREX4mmW71FlxkNCucDfvcVJr0_426fhHELRKG3LAnNpWRJjnwQOQcSgY5sWwyvdM6sjWMda6kxGEytzpRkMtY6a9mOQg9ADVfWmuQbbBeLwhxDhDQDlzKFP3xOZcqk7Cibxnnip3qkLGnA2QZhgebscxSyMIu1ExhNZTGy0AZ8r4EXy1p1Q3jhNsrbcQMuaqDFBlNRJdIZE054OEWA88dbPzyDT_3xzVAMB6PrE9irKkKqbsOfsF2u1uYXfFSP5cytTiuDegLSgtAA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8NAEB60injx_ajPHMSTa9tkN816k2pRrFVQwduy2YcWNC3d1N_vbJKKoAcP3kI2hOVjdvYbZuYbgKMW1YrThJKQW0moiSLCKbUk0ibRnGpuVSHi2mv3-8nzM7-fgbtpL4wvq8xfB-bdEOUrPVTuSy1Gpfqpa5gKYdcYaVuNqWUNR4oqDqT2DG_wU1yahTmG1uhnOTSf4q-0Ak2apXw4p743Lp6qOP74x298Ex_KnX27gLrL_771FViquGhwXhrPKsyYbA0Wbqts-zp0HszIDdxJ0BnKl2rM10kgMx2c--be1_HwHePqs-DuTQc99JhowMUqOs7gOnM-7Hcb8NS9fOxckWroAlHoM3NCUylZlCIrROaBdKAtWxaDLJ0ya8NQh1pqDAljqxMlmQy1Tpq2rdAPUMOVtSbahFo2zMw2BEg28FWi8NinVMZMyraycZhGfrZHzKI6HE5BFmjUPlMhMzOcOIExVRIiF63DVom9GJXaG8LLt1HeCutwXGItprCKIp3OmHDCQyoqSHf--uEhLNxfdEXvun-zC4tFWUjRcrgHtXw8Mfswrz7ygRsfFCb1CRMi0Xo |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sepsis%2C+Coagulation%2C+and+Antithrombin%3A+Old+Lessons+and+New+Insights&rft.jtitle=Seminars+in+thrombosis+and+hemostasis&rft.au=Levi%2C+Marcel&rft.au=Schouten%2C+Marcel&rft.au=van+der+Poll%2C+Tom&rft.date=2008-11-01&rft.issn=0094-6176&rft.eissn=1098-9064&rft.volume=34&rft.issue=8&rft.spage=742&rft.epage=746&rft_id=info:doi/10.1055%2Fs-0029-1145256&rft.externalDBID=HTML_FULL_TEXT&rft.externalDocID=10_1055_s_0029_1145256 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0094-6176&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0094-6176&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0094-6176&client=summon |