YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation

N -methyladenosine (m6A) RNA methylation contributes to the cancer stem cell (CSC) phenotype through regulating gene expression. YTHDF2, an m6A reader, was shown to be associated with hepatocellular carcinoma (HCC) patient prognosis. However, the effect of YTHDF2 on liver CSC and cancer metastasis a...

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Bibliographic Details
Published in:	Oncogene Vol. 39; no. 23; pp. 4507 - 4518
Main Authors:	Zhang, Chuanzhao, Huang, Shanzhou, Zhuang, Hongkai, Ruan, Shiye, Zhou, Zixuan, Huang, Kaijun, Ji, Fei, Ma, Zuyi, Hou, Baohua, He, Xiaoshun
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 04.06.2020
Subjects:	5' Untranslated regions Adenosine - analogs & derivatives Adenosine - metabolism Animals Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell culture DNA methylation Gene expression Gene Expression Regulation, Neoplastic - genetics Genomes Genotype & phenotype Hep G2 Cells Hepatocellular carcinoma Hepatocytes Humans Liver - pathology Liver cancer Liver Neoplasms - mortality Liver Neoplasms - pathology Lung cancer Male Medical prognosis Metastases Metastasis Methylation Mice Mice, Inbred BALB C Mice, Nude N6-methyladenosine Neoplasm Metastasis - pathology Neoplasm Transplantation Neoplastic Stem Cells - pathology Oct-4 protein Octamer Transcription Factor-3 - metabolism Phenotypes Prognosis RNA, Messenger - metabolism RNA-Binding Proteins - genetics Spheroids, Cellular Stem cells Translation Transplantation, Heterologous Tumor Cells, Cultured
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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