HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium

Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical complexity and low possibility of radical surgery, whi...

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Bibliographic Details
Published in:	Oncogene Vol. 38; no. 6; pp. 868 - 880
Main Authors:	Xu, Yun-Fei, Liu, Zeng-Li, Pan, Chang, Yang, Xiao-Qing, Ning, Shang-Lei, Liu, Hong-Da, Guo, Sen, Yu, Jin-Ming, Zhang, Zong-Li
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.02.2019 Nature Publishing Group
Subjects:	631/67 692/53/2422 Angiogenesis Apoptosis Bile Bile Duct Neoplasms - blood Bile Duct Neoplasms - mortality Bile Duct Neoplasms - surgery Bile ducts Biliary tract cancer Biological markers Biomarkers Cancer therapies Care and treatment Cell Biology Cholangiocarcinoma Cholangitis Chromosomal proteins Clinical significance Development and progression Disease-Free Survival Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Epidermal growth factor receptors Female Gene expression Genetic aspects Health aspects HMGB1 protein HMGB1 Protein - blood Human Genetics Humans Immune response Immunohistochemistry Internal Medicine Intracellular Klatskin Tumor - blood Klatskin Tumor - mortality Klatskin Tumor - surgery Lipopolysaccharides Male Medical prognosis Medicine Medicine & Public Health Metastasis Microvasculature Morbidity Multivariate analysis Neoplasm Proteins - blood Neovascularization, Pathologic - blood Neovascularization, Pathologic - mortality Neovascularization, Pathologic - surgery Oncology Patients Prognosis Prospective Studies Surgery Survival Rate Transcription factors Vascular endothelial growth factor
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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