HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium
Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical complexity and low possibility of radical surgery, whi...
Uloženo v:
| Vydáno v: | Oncogene Ročník 38; číslo 6; s. 868 - 880 |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
01.02.2019
Nature Publishing Group |
| Témata: | |
| ISSN: | 0950-9232, 1476-5594, 1476-5594 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical complexity and low possibility of radical surgery, which resulted in the difficulty of specimen obtainment. To screen and identify new biomarkers in PHCCA, we constructed a retrospective cohort with 121 PHCCA patients and a prospective cohort consisting of 64 PHCCA patients, and screened the candidate biomarkers by immunohistochemistry and quantified PCR. In our study, expression of high mobility group box 1 (HMGB1) was demonstrated to be significantly associated with microvascular density (MVD) and unfavorable prognosis of PHCCA in both retrospective and prospective study. Moreover, HMGB1 concentrations in bile and serum of PHCCA patients and healthy controls were detected and compared. Postoperative serum HMGB1 and reflux cholangitis indicated recurrence and unfavorable prognosis of PHCCA. With experiments in vitro and in vivo, we demonstrated that intracellular HMGB1 could be released from PHCCA cells and induce invasion and angiogenesis with LPS stimulation. VEGFR2 expression in vessel endothelial cells was upregulated by the released HMGB1 from PHCCA, resulting in the ectopic angiogenesis. In conclusion, intracellular HMGB1 could be released from PHCCA cells and promote angiogenesis via elevating VEGFR2 in vessel endothelial cells. High expression of HMGB1 was associated with MVD and poor prognosis in clinical analyzation. Postoperative serum HMGB1 and cholangitis could predict high recurrence and unfavorable prognosis. |
|---|---|
| AbstractList | Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical complexity and low possibility of radical surgery, which resulted in the difficulty of specimen obtainment. To screen and identify new biomarkers in PHCCA, we constructed a retrospective cohort with 121 PHCCA patients and a prospective cohort consisting of 64 PHCCA patients, and screened the candidate biomarkers by immunohistochemistry and quantified PCR. In our study, expression of high mobility group box 1 (HMGB1) was demonstrated to be significantly associated with microvascular density (MVD) and unfavorable prognosis of PHCCA in both retrospective and prospective study. Moreover, HMGB1 concentrations in bile and serum of PHCCA patients and healthy controls were detected and compared. Postoperative serum HMGB1 and reflux cholangitis indicated recurrence and unfavorable prognosis of PHCCA. With experiments in vitro and in vivo, we demonstrated that intracellular HMGB1 could be released from PHCCA cells and induce invasion and angiogenesis with LPS stimulation. VEGFR2 expression in vessel endothelial cells was upregulated by the released HMGB1 from PHCCA, resulting in the ectopic angiogenesis. In conclusion, intracellular HMGB1 could be released from PHCCA cells and promote angiogenesis via elevating VEGFR2 in vessel endothelial cells. High expression of HMGB1 was associated with MVD and poor prognosis in clinical analyzation. Postoperative serum HMGB1 and cholangitis could predict high recurrence and unfavorable prognosis. Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical complexity and low possibility of radical surgery, which resulted in the difficulty of specimen obtainment. To screen and identify new biomarkers in PHCCA, we constructed a retrospective cohort with 121 PHCCA patients and a prospective cohort consisting of 64 PHCCA patients, and screened the candidate biomarkers by immunohistochemistry and quantified PCR. In our study, expression of high mobility group box 1 (HMGB1) was demonstrated to be significantly associated with microvascular density (MVD) and unfavorable prognosis of PHCCA in both retrospective and prospective study. Moreover, HMGB1 concentrations in bile and serum of PHCCA patients and healthy controls were detected and compared. Postoperative serum HMGB1 and reflux cholangitis indicated recurrence and unfavorable prognosis of PHCCA. With experiments in vitro and in vivo, we demonstrated that intracellular HMGB1 could be released from PHCCA cells and induce invasion and angiogenesis with LPS stimulation. VEGFR2 expression in vessel endothelial cells was upregulated by the released HMGB1 from PHCCA, resulting in the ectopic angiogenesis. In conclusion, intracellular HMGB1 could be released from PHCCA cells and promote angiogenesis via elevating VEGFR2 in vessel endothelial cells. High expression of HMGB1 was associated with MVD and poor prognosis in clinical analyzation. Postoperative serum HMGB1 and cholangitis could predict high recurrence and unfavorable prognosis.Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers made progresses slowly compared with intrahepatic cholangiocarcinoma because of surgical complexity and low possibility of radical surgery, which resulted in the difficulty of specimen obtainment. To screen and identify new biomarkers in PHCCA, we constructed a retrospective cohort with 121 PHCCA patients and a prospective cohort consisting of 64 PHCCA patients, and screened the candidate biomarkers by immunohistochemistry and quantified PCR. In our study, expression of high mobility group box 1 (HMGB1) was demonstrated to be significantly associated with microvascular density (MVD) and unfavorable prognosis of PHCCA in both retrospective and prospective study. Moreover, HMGB1 concentrations in bile and serum of PHCCA patients and healthy controls were detected and compared. Postoperative serum HMGB1 and reflux cholangitis indicated recurrence and unfavorable prognosis of PHCCA. With experiments in vitro and in vivo, we demonstrated that intracellular HMGB1 could be released from PHCCA cells and induce invasion and angiogenesis with LPS stimulation. VEGFR2 expression in vessel endothelial cells was upregulated by the released HMGB1 from PHCCA, resulting in the ectopic angiogenesis. In conclusion, intracellular HMGB1 could be released from PHCCA cells and promote angiogenesis via elevating VEGFR2 in vessel endothelial cells. High expression of HMGB1 was associated with MVD and poor prognosis in clinical analyzation. Postoperative serum HMGB1 and cholangitis could predict high recurrence and unfavorable prognosis. |
| Audience | Academic |
| Author | Liu, Zeng-Li Xu, Yun-Fei Ning, Shang-Lei Liu, Hong-Da Pan, Chang Guo, Sen Yang, Xiao-Qing Zhang, Zong-Li Yu, Jin-Ming |
| Author_xml | – sequence: 1 givenname: Yun-Fei surname: Xu fullname: Xu, Yun-Fei organization: Department of General Surgery, Qilu Hospital of Shandong University – sequence: 2 givenname: Zeng-Li surname: Liu fullname: Liu, Zeng-Li organization: Department of General Surgery, Qilu Hospital of Shandong University – sequence: 3 givenname: Chang surname: Pan fullname: Pan, Chang organization: Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University – sequence: 4 givenname: Xiao-Qing surname: Yang fullname: Yang, Xiao-Qing organization: Department of Pathology, Qianfoshan Hospital of Shandong University – sequence: 5 givenname: Shang-Lei surname: Ning fullname: Ning, Shang-Lei organization: Department of General Surgery, Qilu Hospital of Shandong University – sequence: 6 givenname: Hong-Da surname: Liu fullname: Liu, Hong-Da organization: Department of Pharmacology & Chemical Biology, University of Pittsburgh – sequence: 7 givenname: Sen surname: Guo fullname: Guo, Sen organization: Department of General Surgery, Qilu Hospital of Shandong University – sequence: 8 givenname: Jin-Ming surname: Yu fullname: Yu, Jin-Ming email: sdyujinming@163.com organization: Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences – sequence: 9 givenname: Zong-Li surname: Zhang fullname: Zhang, Zong-Li email: zzlzzl1900@163.com organization: Department of General Surgery, Qilu Hospital of Shandong University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30177842$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kl1rFDEUhoNU7Lb6A7yRgDfeTM3XTGYua2m3hYog6m3IZk5mUzLJmsxu8c6fbqbbUixaQgg5ed7zkXOO0EGIARB6S8kJJbz9mAXlbVsRWrZo66p9gRZUyKaq604coAXpalJ1jLNDdJTzDSFEdoS9QoecUClbwRbo9-Xn5SeKTUwJvJ4g41s3rbEOg4sDBMgul0uPNzEmvElxCHE2RYs3kNzaeZ2wWUd_JzA6GRfiqPHOaQwednpyYcA_zpcXX9ks2kHO4DGEPk5r8G47vkYvrfYZ3tyfx-j7xfm3s8vq-svy6uz0ujKikVMl2MoY01HJG2Dadk0PwlrbWw7CUGuazjQE-pUppZuuEZyDYYz0goAWREp-jD7s_ZYifm4hT2p02YAvmUPcZsVI1wneUNEW9P0T9CZuUyjZKc445TVvhXiOYlQ2kkhay0dq0B6UCzZOSZs5tDotz5TJmpBCnfyDKquH0ZnSdOuK_S_Bu_vg29UIvdokN-r0Sz00tgByD5gUc05glXFT6UYMxbPzihI1j5Daj5AqI6TmEVJz9fSJ8sH5cxq21-TChgHS41_8X_QHqpjW-A |
| CitedBy_id | crossref_primary_10_1089_ars_2023_0236 crossref_primary_10_1016_j_cellsig_2023_110904 crossref_primary_10_1097_HEP_0000000000000437 crossref_primary_10_3389_fimmu_2022_1049812 crossref_primary_10_1038_s41388_021_01850_1 crossref_primary_10_1097_PAI_0000000000000917 crossref_primary_10_1111_jcmm_17857 crossref_primary_10_1186_s13046_021_01890_1 crossref_primary_10_1016_j_ebiom_2019_06_023 crossref_primary_10_1038_s41388_022_02313_x crossref_primary_10_3389_fphar_2024_1435639 crossref_primary_10_1038_s41388_021_01844_z crossref_primary_10_1155_2021_4933194 crossref_primary_10_1007_s11845_020_02199_2 crossref_primary_10_1111_joor_13129 crossref_primary_10_3389_fonc_2021_757498 crossref_primary_10_23736_S0390_5616_20_04929_2 crossref_primary_10_3389_fonc_2021_730615 crossref_primary_10_1002_2211_5463_13142 crossref_primary_10_1016_j_ymthe_2021_02_017 crossref_primary_10_23736_S0390_5616_20_05107_3 crossref_primary_10_1016_j_biopha_2019_109583 crossref_primary_10_1016_j_scr_2020_102122 crossref_primary_10_1016_j_ebiom_2019_08_062 crossref_primary_10_1124_jpet_119_263202 crossref_primary_10_1038_s41419_020_2549_2 crossref_primary_10_1038_s41419_025_07543_x crossref_primary_10_1038_s41419_021_04451_8 crossref_primary_10_1016_j_tranon_2024_101905 crossref_primary_10_1007_s11845_020_02263_x crossref_primary_10_3390_cancers12102817 crossref_primary_10_1016_j_ebiom_2019_11_021 crossref_primary_10_1177_00368504251362343 crossref_primary_10_3389_fonc_2023_1140103 crossref_primary_10_3390_cimb46040228 crossref_primary_10_1016_j_ajpath_2022_08_008 crossref_primary_10_1007_s00018_022_04500_1 crossref_primary_10_1016_j_jhep_2020_04_033 crossref_primary_10_1111_jgh_14854 crossref_primary_10_1007_s11845_021_02737_6 crossref_primary_10_1080_14728222_2021_2010046 crossref_primary_10_3390_cells11050849 crossref_primary_10_1186_s13046_021_01877_y crossref_primary_10_1016_j_prp_2019_03_026 crossref_primary_10_1136_gutjnl_2023_331715 crossref_primary_10_3389_fonc_2021_777617 crossref_primary_10_3389_fonc_2022_972550 |
| Cites_doi | 10.1158/0008-5472.CAN-05-2217 10.1053/j.gastro.2013.10.013 10.1002/path.1031 10.1038/cr.2017.51 10.2119/molmed.2015.00087 10.1016/S0002-9440(10)62296-1 10.1002/path.2391 10.1053/j.gastro.2013.01.001 10.1089/ars.2010.3356 10.1038/sj.bjc.6604129 10.1152/ajpregu.00184.2009 10.1038/nature18317 10.1172/JCI76887 10.1038/onc.2012.49 10.1016/S0140-6736(13)61903-0 10.3748/wjg.v21.i11.3256 10.1097/01.sla.0000251366.62632.d3 10.1016/j.bbagrm.2009.09.008 10.1016/j.bbrc.2014.02.050 10.1128/MCB.23.8.2991-2998.2003 10.4161/auto.23691 10.1155/2013/157103 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2018 corrected publication 2025 COPYRIGHT 2019 Nature Publishing Group Copyright Nature Publishing Group Feb 2019 Springer Nature Limited 2018 |
| Copyright_xml | – notice: Springer Nature Limited 2018 corrected publication 2025 – notice: COPYRIGHT 2019 Nature Publishing Group – notice: Copyright Nature Publishing Group Feb 2019 – notice: Springer Nature Limited 2018 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 |
| DOI | 10.1038/s41388-018-0485-8 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (ProQuest) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Research Library Biological Science Database (ProQuest) Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic Research Library Prep |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Biology |
| EISSN | 1476-5594 |
| EndPage | 880 |
| ExternalDocumentID | A573127500 30177842 10_1038_s41388_018_0485_8 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -Q- 0R~ 123 29N 2WC 36B 39C 4.4 406 53G 5RE 70F 7X7 8AO 8C1 8FE 8FH 8G5 8R4 8R5 AACDK AANZL AASML AATNV AAYZH ABAKF ABBRH ABDBE ABFSG ABJNI ABLJU ABRTQ ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACPRK ACRQY ACSTC ACZOJ ADBBV ADFRT AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AEZWR AFBBN AFDZB AFHIU AFKRA AFSHS AGHAI AGQEE AHMBA AHSBF AHWEU AIGIU AILAN AIXLP AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF ASPBG ATHPR AVWKF AXYYD AYFIA AZFZN AZQEC BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CS3 DIK DNIVK DPUIP DU5 E3Z EAP EBLON EBS EE. EIOEI EJD ESX F5P FDQFY FEDTE FERAY FIGPU FIZPM FSGXE FYUFA GUQSH HCIFZ HVGLF HZ~ IAO IHR INH INR ITC IWAJR JSO JZLTJ KQ8 L7B LGEZI LK8 LOTEE M1P M2O M7P N9A NADUK NQJWS NXXTH O9- OK1 P2P PQQKQ PROAC PSQYO Q2X RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SWTZT TAOOD TBHMF TDRGL TSG UKHRP WH7 88E 8FI 8FJ AAYXX ABUWG AFFHD CCPQU CITATION DWQXO GNUQQ HMCUK PHGZM PHGZT PJZUB PPXIY PQGLB TUS .55 .GJ 3O- ABAWZ ABDBF ABEFU ACUHS AFFNX B0M BAWUL CAG CGR COF CUY CVF EAD EBC EBD ECM EIF EMB EMK EMOBN EPL NPM OVD RNS SV3 TEORI TR2 UDS X7M ZXP ~8M 3V. 7TM 7TO 7U9 7XB 88A 8FD 8FK FR3 H94 K9. MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 PUEGO |
| ID | FETCH-LOGICAL-c467t-42bccc91736e2af96de4fffdf3e4c1fc69c60edbc559c96433ec220d40ea40773 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 64 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000458006300008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0950-9232 1476-5594 |
| IngestDate | Thu Oct 02 10:35:28 EDT 2025 Tue Oct 07 05:44:30 EDT 2025 Mon Oct 06 18:19:14 EDT 2025 Tue Nov 11 10:31:27 EST 2025 Tue Nov 04 17:56:09 EST 2025 Thu Jul 31 01:53:54 EDT 2025 Tue Nov 18 22:34:20 EST 2025 Sat Nov 29 07:36:28 EST 2025 Wed Jul 30 01:15:19 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c467t-42bccc91736e2af96de4fffdf3e4c1fc69c60edbc559c96433ec220d40ea40773 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 30177842 |
| PQID | 2176707157 |
| PQPubID | 36330 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_2099436148 proquest_journals_3231353844 proquest_journals_2176707157 gale_infotracmisc_A573127500 gale_infotracacademiconefile_A573127500 pubmed_primary_30177842 crossref_citationtrail_10_1038_s41388_018_0485_8 crossref_primary_10_1038_s41388_018_0485_8 springer_journals_10_1038_s41388_018_0485_8 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-02-00 |
| PublicationDateYYYYMMDD | 2019-02-01 |
| PublicationDate_xml | – month: 02 year: 2019 text: 2019-02-00 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England – name: New York |
| PublicationTitle | Oncogene |
| PublicationTitleAbbrev | Oncogene |
| PublicationTitleAlternate | Oncogene |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Q Zhang (485_CR7) 2013; 9 DC Avgousti (485_CR8) 2016; 535 D Wu (485_CR13) 2008; 216 N Razumilava (485_CR1) 2014; 383 R Kang (485_CR24) 2017; 27 S Rizvi (485_CR4) 2017; 15 R Yang (485_CR22) 2009; 297 I Poser (485_CR9) 2003; 23 S Rizvi (485_CR2) 2013; 145 H Kuniyasu (485_CR10) 2002; 196 M Gnanasekar (485_CR12) 2013; 2013 JR van Beijnum (485_CR19) 2013; 32 H Yang (485_CR20) 2015; 21 KD Lillemoe (485_CR3) 2003; 14 ML DeOliveira (485_CR5) 2007; 245 YF Xu (485_CR17) 2014; 446 D Yoshikawa (485_CR16) 2008; 98 M Stros (485_CR6) 2010; 1799 YF Xu (485_CR14) 2015; 21 H Kuniyasu (485_CR11) 2005; 166 P Huebener (485_CR21) 2015; 125 D Tang (485_CR23) 2011; 14 D Sia (485_CR15) 2013; 144 J Dixelius (485_CR18) 2006; 66 40730916 - Oncogene. 2025 Jul 29. doi: 10.1038/s41388-025-03514-w. |
| References_xml | – volume: 66 start-page: 2089 year: 2006 ident: 485_CR18 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2217 – volume: 145 start-page: 1215 year: 2013 ident: 485_CR2 publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.10.013 – volume: 196 start-page: 163 year: 2002 ident: 485_CR10 publication-title: J Pathol doi: 10.1002/path.1031 – volume: 27 start-page: 916 year: 2017 ident: 485_CR24 publication-title: Cell Res doi: 10.1038/cr.2017.51 – volume: 21 start-page: S6 issue: Suppl 1 year: 2015 ident: 485_CR20 publication-title: Mol Med doi: 10.2119/molmed.2015.00087 – volume: 14 start-page: 208 year: 2003 ident: 485_CR3 publication-title: Semin Gastrointest Dis – volume: 166 start-page: 751 year: 2005 ident: 485_CR11 publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)62296-1 – volume: 216 start-page: 167 year: 2008 ident: 485_CR13 publication-title: J Pathol doi: 10.1002/path.2391 – volume: 144 start-page: 829 year: 2013 ident: 485_CR15 publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.01.001 – volume: 14 start-page: 1315 year: 2011 ident: 485_CR23 publication-title: Antioxid Redox Signal doi: 10.1089/ars.2010.3356 – volume: 98 start-page: 418 year: 2008 ident: 485_CR16 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604129 – volume: 297 start-page: R362 year: 2009 ident: 485_CR22 publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00184.2009 – volume: 535 start-page: 173 year: 2016 ident: 485_CR8 publication-title: Nature doi: 10.1038/nature18317 – volume: 125 start-page: 539 year: 2015 ident: 485_CR21 publication-title: J Clin Invest doi: 10.1172/JCI76887 – volume: 32 start-page: 363 year: 2013 ident: 485_CR19 publication-title: Oncogene doi: 10.1038/onc.2012.49 – volume: 383 start-page: 2168 year: 2014 ident: 485_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(13)61903-0 – volume: 15 start-page: 95 year: 2017 ident: 485_CR4 publication-title: Nat Rev Clin Oncol – volume: 21 start-page: 3256 year: 2015 ident: 485_CR14 publication-title: World J Gastroenterol doi: 10.3748/wjg.v21.i11.3256 – volume: 245 start-page: 755 year: 2007 ident: 485_CR5 publication-title: Ann Surg doi: 10.1097/01.sla.0000251366.62632.d3 – volume: 1799 start-page: 101 year: 2010 ident: 485_CR6 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbagrm.2009.09.008 – volume: 446 start-page: 54 year: 2014 ident: 485_CR17 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2014.02.050 – volume: 23 start-page: 2991 year: 2003 ident: 485_CR9 publication-title: Mol Cell Biol doi: 10.1128/MCB.23.8.2991-2998.2003 – volume: 9 start-page: 451 year: 2013 ident: 485_CR7 publication-title: Autophagy doi: 10.4161/auto.23691 – volume: 2013 start-page: 157103 year: 2013 ident: 485_CR12 publication-title: Prostate Cancer doi: 10.1155/2013/157103 – reference: 40730916 - Oncogene. 2025 Jul 29. doi: 10.1038/s41388-025-03514-w. |
| SSID | ssj0007902 |
| Score | 2.5301352 |
| Snippet | Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers... |
| SourceID | proquest gale pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 868 |
| SubjectTerms | 631/67 692/53/2422 Angiogenesis Apoptosis Bile Bile Duct Neoplasms - blood Bile Duct Neoplasms - mortality Bile Duct Neoplasms - surgery Bile ducts Biliary tract cancer Biological markers Biomarkers Cancer therapies Care and treatment Cell Biology Cholangiocarcinoma Cholangitis Chromosomal proteins Clinical significance Development and progression Disease-Free Survival Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Epidermal growth factor receptors Female Gene expression Genetic aspects Health aspects HMGB1 protein HMGB1 Protein - blood Human Genetics Humans Immune response Immunohistochemistry Internal Medicine Intracellular Klatskin Tumor - blood Klatskin Tumor - mortality Klatskin Tumor - surgery Lipopolysaccharides Male Medical prognosis Medicine Medicine & Public Health Metastasis Microvasculature Morbidity Multivariate analysis Neoplasm Proteins - blood Neovascularization, Pathologic - blood Neovascularization, Pathologic - mortality Neovascularization, Pathologic - surgery Oncology Patients Prognosis Prospective Studies Surgery Survival Rate Transcription factors Vascular endothelial growth factor |
| Title | HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium |
| URI | https://link.springer.com/article/10.1038/s41388-018-0485-8 https://www.ncbi.nlm.nih.gov/pubmed/30177842 https://www.proquest.com/docview/2176707157 https://www.proquest.com/docview/3231353844 https://www.proquest.com/docview/2099436148 |
| Volume | 38 |
| WOSCitedRecordID | wos000458006300008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database (ProQuest) customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: M7P dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: 8C1 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-5594 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0007902 issn: 0950-9232 databaseCode: M2O dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEB6apK9LH9uX23RRoVBoMLElrSWfSrLsJpfdLqEtezO2LKeGjb3dF_TWn94ZPzbd0ObSgw22LGExo9GM5vEBvOep9KThmau5pZScULmx7EnXC4xvgsT4KpEV2IQaj_V0Gk6aA7dlE1bZysRKUKeloTPyY4GKiMDVKeWn-Q-XUKPIu9pAaOzBAVVJ4FXo3mQriVUdc4hahOeiIsNbr6bQx0sU3prCuPCSuufqnX3ppnT-Y3u64S-ttqHh4_-dwBN41Cig7KTmmKdwxxYduFdDUv7swIN-iwDXgfujxvH-DH6dj85OfWYIy2NG6imjA1wWF5d5eUniMl_iQ8rmZblgFPNVlPSqzBhVUv6eo_3MKjOaOhjCLyrKq5ht8phRgntMwdfs2-BseMGp04Yqms-YLVJKEJvl66vn8HU4-NI_dxvwBteg7F25kifGGDQGRWB5nIVBamWWZWkmrDR-ZoLQBJ5NE4MmjaGiYMIazj1kHRujkanEC9gvysK-AhYmibWqSiPWUvBUJ2i26yDRhqP2FSsHvJZ0kWkqmxPAxiyqPOxCRzW1I6R2RNSOtAMft13mdVmP2z7-QPwQ0ZLHcU3cZC7g31HxrOikp0RVJ99z4HDnS6SX2W1uWSNqRMUyQpswUKjo9dRfm6_ZxoF322YamKLjCluucQhU86Wgkq4OvKwZdTsrFOBKackdOGo593rwf0759e2_8gYeouIY1tHrh7C_WqztW7hrNqt8uejCnpqq6q7xrvt-Fw5OB-PJBT6N-OdutUh_A3kPOfo |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6V8igXHuFlKLBIICSQVWd3410fECqlaao2AaGCejP2el0spXbIC_XGL-I3MuNHSirorQci5ZCsd-S157n7zQzAc55ITxqeuppbSskJlBvJjnQ937SNH5u2imXZbEINBvrwMPi4Ar-aXBiCVTY6sVTUSWFoj3xDoCMiUDqlfDv67lLXKDpdbVpoVGyxZ09-YMg2ebP7Ht_vC8672wdbPbfuKuAaVApTV_LYGINRivAtj9LAT6xM0zRJhZWmnRo_ML5nk9igr22oWpWwhnMP12QjjH6UQLqX4LKkSIiggvzDQvOrCuOIXovnouPEm1NUoTcmaCw0wcbwK3XH1Ut28Kw1-MMcnjmfLc1e9-b_9sBuwY3awWablUTchhWbt-Bq1XLzpAVrW02HuxZc69fAgjvws9ffeddmhnqVDMn9ZrRBzaL8KCuOyBxkE_yRsFFRjBlh2vKC_ipSRpWiv2XDaMzKbQKaYKg_U14cR2yeRYwS-CMCl7Mv2zvdT5wmzali-5DZPKEEuGE2O74Lny_kqdyD1bzI7QNgQRxbq8o0aS0FT3Ss8ePH2nD0LiPlgNewSmjqyu3UQGQYlggCocOKu0LkrpC4K9QOvFpMGVVlS867-CXxX0gqDemaqM7MwLuj4mDhZkeJsg-A58D60pX4vszycMOKYa0KJyHGvL5CWemovw6fsqkDzxbDRJjQf7ktZkgCwxgpqGStA_crwVisCg2UUlpyB143knJK_J9Lfnj-rTyFtd5Bfz_c3x3sPYLr6CQHFVJ_HVan45l9DFfMfJpNxk9KBcDg60UL0G8IC5RY |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9NAFH4qKRQuLGEzFBgkEBKVFWc88YwPCHVJ2qo0iipAvbn2eFwspXbIhnrjd_HreM9LSirorQci5ZCM58ljv-V7M28BeMNj4QjNE1txQyk5vrRD0RG24-m29iLdlpEomk3Ifl8dH_uDFfhV58JQWGWtEwtFHeea9shbLgIRF6VTiFZShUUMdnofR99t6iBFJ611O42SRQ7M-Q903yYf9nfwXb_lvNf9vL1nVx0GbI0KYmoLHmmt0WNxPcPDxPdiI5IkiRPXCN1OtOdrzzFxpBF3a6pc5RrNuYPrMyF6QtJFujdgVSLIEA1Y3er2B0cLOyDLiEfEMI6NMIrXZ6quak3QdCgKIsOvUB1bLVnFy7bhD-N46bS2MIK9e__z47sPdyvozTZLWXkAKyZrwq2yGed5E25v173vmrB2WIUcPISfe4e7W22mqYvJkIA5o61rFmanaX5KhiKd4I-YjfJ8zCjaLcvprzxhVEP6WzoMx6zYQKAJmjo3ZflZyOZpyCi1P6Swc_a1u9s74jRpTrXch8xkMaXGDdPZ2SP4ci1P5TE0sjwzT4H5UWSMLBKolXB5rCKFHy9SmiPuDKUFTs02ga5qulNrkWFQxBa4Kig5LUBOC4jTAmXB-8WUUVnQ5KqL3xEvBqTskK4Oq5wNvDsqGxZsdqRbdAhwLFhfuhLfl14ertkyqJTkJEBv2JMIcTvyr8MXLGvB68UwEaa4wMzkMySBDo5wqZitBU9KIVmsCk2XlEpwCzZqqbkg_s8lP7v6Vl7BGspN8Gm_f_Ac7iB69ssQ_nVoTMcz8wJu6vk0nYxfVtqAwcl1S9Bv-P-edQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HMGB1+correlates+with+angiogenesis+and+poor+prognosis+of+perihilar+cholangiocarcinoma+via+elevating+VEGFR2+of+vessel+endothelium&rft.jtitle=Oncogene&rft.au=Xu%2C+Yun-Fei&rft.au=Liu%2C+Zeng-Li&rft.au=Pan%2C+Chang&rft.au=Yang%2C+Xiao-Qing&rft.date=2019-02-01&rft.pub=Nature+Publishing+Group&rft.issn=0950-9232&rft.volume=38&rft.issue=6&rft.spage=868&rft_id=info:doi/10.1038%2Fs41388-018-0485-8&rft.externalDocID=A573127500 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon |