The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats

Coproporphyrin I (CPI) and III (CPIII) are discussed as biomarkers for organic anion transporting polypeptides (OATPs). We report on CPI and CPIII levels in wildtype, rSlco2b1-knockout, and SLCO2B1-humanized rats at baseline and after administration of atorvastatin, an inhibitor of the CPIII-specifi...

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Bibliographic Details

Published in:	Journal of pharmacological sciences Vol. 153; no. 3; pp. 170 - 174
Main Authors:	Kinzi, Jonny, Grube, Markus, Hussner, Janine, Seibert, Isabell, Hamburger, Matthias, Meyer zu Schwabedissen, Henriette E.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01.11.2023 Elsevier
Subjects:	Atorvastatin Coproporphyrin OATP2B1 Atorvastatin Coproporphyrin OATP2B1
ISSN:	1347-8613, 1347-8648, 1347-8648
Online Access:	Get full text
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