Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus

Accumulating evidence suggests that metformin reduces the incidence and mortality of colorectal cancer (CRC). However, underlying mechanisms have not been fully clarified. The aim of this study was to examine the pathological characteristics of resected CRC from patients treated with metformin for t...

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Bibliographic Details
Published in:	Cancer science Vol. 111; no. 11; pp. 4012 - 4020
Main Authors:	Saito, Akira, Kitayama, Joji, Horie, Hisanaga, Koinuma, Koji, Ohzawa, Hideyuki, Yamaguchi, Hironori, Kawahira, Hiroshi, Mimura, Toshiki, Lefor, Alan Kawarai, Sata, Naohiro
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.11.2020 John Wiley and Sons Inc
Subjects:	Adult Aged Aged, 80 and over Antibodies CD163 antigen CD3 antigen CD8 antigen Cloning Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - complications Colorectal Neoplasms - immunology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Female Fibrosis Gender Hemoglobin Humans Hypoglycemic Agents - pharmacology Immunohistochemistry Insulin Invasiveness Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Macrophages Male Metastasis Metformin Metformin - pharmacology Middle Aged Mortality Neoplasm Metastasis Neoplasm Staging Original Phenotypes Regression analysis Stroma Surgery tertiary lymphoid structure Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tumor-Associated Macrophages - drug effects Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism Tumors tumor‐associated macrophage tumor‐infiltrating lymphocytes Denmark tertiary lymphoid structure metformin tumor-associated macrophage tumor-infiltrating lymphocytes colorectal cancer
ISSN:	1347-9032, 1349-7006, 1349-7006
Online Access:	Get full text
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