Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis

Vitiligo is a commonly acquired pigmentary disease characterized by the progressive destruction of melanocytes. The role of adipose tissue in vitiligo remains unclear. To investigate the role of adipose tissue in the pathogenesis of vitiligo, 50 patients newly diagnosed with vitiligo and 40 age- and...

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Bibliographic Details
Published in:Acta dermato-venereologica Vol. 104; p. adv41018
Main Authors: Shao, XinYi, Pan, Xingyu, Chen, Tingqiao, Chen, Ziyan, Li, Yuhao, Zhong, Judan, Wang, Ruiyao, Yu, Jun, Chen, Jin, Chen, Yangmei
Format: Journal Article
Language:English
Published: Sweden MJS Publishing, on behalf of the Society for Publication of Acta Dermato-Venereologica 19.11.2024
Medical Journals Sweden
Subjects:
Absorptiometry, Photon
adipokines
Adipokines - blood
Adiponectin - blood
adipose tissue
Adipose Tissue - metabolism
Adiposity
Adult
Biomarkers - blood
Body Composition
body composition analysis
Body Fat Distribution
Case-Control Studies
dual-energy X-ray absorptiometry
Female
Humans
Leptin - blood
Male
Middle Aged
Obesity, Abdominal - physiopathology
Original
Predictive Value of Tests
Resistin - blood
vitiligo
Vitiligo - blood
Vitiligo - physiopathology
Young Adult
ISSN:0001-5555, 1651-2057, 1651-2057
Online Access:Get full text
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Summary:Vitiligo is a commonly acquired pigmentary disease characterized by the progressive destruction of melanocytes. The role of adipose tissue in vitiligo remains unclear. To investigate the role of adipose tissue in the pathogenesis of vitiligo, 50 patients newly diagnosed with vitiligo and 40 age- and sex-matched healthy controls were enrolled, and fat mass and distribution using dual-energy X-ray absorptiometry (DXA) and serum adipokine levels using enzyme-linked immunosorbent assay were assessed. The trunk and whole-body fat mass and the trunk/limb fat mass ratio were significantly higher in patients with vitiligo. Higher leptin and resistin levels and lower adiponectin levels were observed. Positive correlation of the trunk fat mass index with vitiligo area scoring index scores (r = 0.38, p = 0.0071) was found. Additionally, plasma adiponectin levels were negatively correlated with vitiligo disease activity scores (r = –0.307, p < 0.05). Receiver operating characteristic curve analysis showed that the percentage of limb lean tissue mass, trunk/limb fat mass ratio, and serum adipokine levels achieved a high area under the curve score for distinguishing patients with vitiligo from healthy controls. In conclusion, the incidence of central obesity and adipokine dysregulation was higher in patients with vitiligo. The potential role of adipose tissue in the pathogenesis of vitiligo should be emphasized.
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These authors contributed to the work equally.
ISSN:0001-5555
1651-2057
1651-2057
DOI:10.2340/actadv.v104.41018