Levamisole-associated multifocal inflammatory encephalopathy: clinical and MRI characteristics, and diagnostic algorithm

•LAMIE is an important diagnostic consideration in the demyelinating episode in developing countries.•Only 1/5 of LAMIE patients with specific oligoclonal bands synthesis in CSF convert to multiple sclerosis.•Three MRI LAMIE patterns were described. Levamisole-associated multifocal inflammatory ence...

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Vydáno v:Multiple sclerosis and related disorders Ročník 69; s. 104418
Hlavní autoři: Fominykh, V., Averchenkov, D., Volik, A., Popova, E., Bryukhov, V., Nazarov, V., Moshnikova, A., Arzumanian, N., Tatarenko, A., Nechaev, V., Manuylova, O., Lapin, S., Brylev, L., Guekht, A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.01.2023
Témata:
ADEM
Brain - diagnostic imaging
Brain - pathology
Demyelinating disorders
Encephalomyelitis, Acute Disseminated - pathology
Female
Humans
Levamisole
Levamisole - adverse effects
Levamisole-associated multifocal inflammatory encephalopathy
Magnetic Resonance Imaging
Male
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - drug therapy
Multiple Sclerosis - pathology
Neuroinflammation
Neurology
Retrospective Studies
Neuroinflammation
Multiple sclerosis
Demyelinating disorders
Levamisole-associated multifocal inflammatory encephalopathy
ADEM
Levamisole
demyelinating disorders
levamisole
neuroinflammation
multiple sclerosis
levamisole-associated multifocal inflammatory encephalopathy
ISSN:2211-0348, 2211-0356, 2211-0356
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Shrnutí:•LAMIE is an important diagnostic consideration in the demyelinating episode in developing countries.•Only 1/5 of LAMIE patients with specific oligoclonal bands synthesis in CSF convert to multiple sclerosis.•Three MRI LAMIE patterns were described. Levamisole-associated multifocal inflammatory encephalopathy (LAMIE) is a devastating adverse effect of levamisole (LEV) treatment. In Russia, people often use LEV without a doctor's prescription for anthelmintic prophylaxis. LAMIE often misdiagnosed as the first episode of MS or acute disseminated encephalomyelitis (ADEM). The aim of our study was to describe clinical, laboratory and morphological characteristics of LAMIE, magnetic resonance imaging (MRI) patterns and create an algorithm for the differential diagnosis. This study was a prospective observational study with retrospective analysis of cases. It was performed at two hospitals with ambulatory service for MS. We included 43 patients with LAMIE with follow-up was from 1 year to 5 years. Age was 19-68 y.o. with female predominance. The most typical manifestations of LAMIE were cerebellar, pyramidal and cognitive symptoms, and majority of patients had biphasic course of the disease. Three main types of MRI patterns were described: ADEM-like, MS-like, atypical demyelination. About 40% of patients had CSF specific oligoclonal bands synthesis, but only 20 % of them converted to MS during the period from 1 month until 2 years. The CSF albumin levels and immunoglobulin G index were elevated in LAMIE patients compared to reference values. We described results of brain biopsy in two cases. Therefore LAMIE should be considered in patients with demyelinating or inflammatory conditions with biphasic onset of the disease and variable MRI presentation. [Display omitted]
Bibliografie:ObjectType-Article-2
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ISSN:2211-0348
2211-0356
2211-0356
DOI:10.1016/j.msard.2022.104418