Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans

Elevated plasma IL-18 is present in several conditions sharing insulin-resistance as common trait, but the association with insulin-resistance per se is not established. Plasma/serum IL-6, IL-18, TNF-α, soluble TNF receptor II (sTNFR2), and C-reactive protein (CRP) were measured in 97 patients with...

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Bibliographic Details
Published in:Clinical Immunology Vol. 117; no. 2; pp. 152 - 160
Main Authors: Fischer, Christian P., Perstrup, Lisbeth B., Berntsen, Annika, Eskildsen, Peter, Pedersen, Bente K.
Format: Journal Article
Language:English
Published: San Diego, CA Elsevier Inc 01.11.2005
Elsevier
Subjects:
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - metabolism
Case-Control Studies
Cross-Sectional Studies
Cytokines
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - metabolism
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
Inflammation
Insulin resistance
Insulin Resistance - physiology
Interleukin-18 - blood
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Obesity
Receptors, Tumor Necrosis Factor, Type II - blood
Tumor Necrosis Factor-alpha - metabolism
Type 2 diabetes
CRP
SBP
Type 2 diabetes
Obesity
OR
Cytokines
Inflammation
Epidemiology
IL-6
HDL
HOMA-IR
DBP
TNF-α
IL-18
sTNFR2
Insulin resistance
TAG
TZD
Endocrinopathy
Human
Immunopathology
Pancreatic hormone
Cytokine
Biological marker
Metabolic diseases
Insulin
Interleukin 18
Blood plasma
Target tissue resistance
Immunology
ISSN:1521-6616, 1521-7035, 1365-2567
Online Access:Get full text
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Summary:Elevated plasma IL-18 is present in several conditions sharing insulin-resistance as common trait, but the association with insulin-resistance per se is not established. Plasma/serum IL-6, IL-18, TNF-α, soluble TNF receptor II (sTNFR2), and C-reactive protein (CRP) were measured in 97 patients with type 2 diabetes (DM) and 84 non-diabetic controls (CON). The association with insulin-resistance—estimated using the homeostasis model assessment (HOMA-IR)—was analyzed using multivariate linear and logistic regression. Compared to CON, DM demonstrated higher plasma levels of IL-18 ( P = 0.001), IL-6 ( P < 0.001), sTNFR2 ( P = 0.005), and CRP ( P < 0.001), while TNF-α was lower ( P = 0.017). Plasma IL-18 increased across HOMA-IR quartiles in both DM and CON, both with and without adjustment for confounders (all P < 0.05). In contrast, neither IL-6, TNF-α, sTNFR2, nor CRP was associated with HOMA-IR in CON when adjusting for confounders. Accordingly, 50% increase of IL-18 corresponded to a marked increase of HOMA-IR in both DM and CON (DM: 26%, P = 0.014; CON: 25%, P = 0.003) after adjustment for confounders. Our results show that plasma IL-18 was associated with HOMA-IR independent of obesity and type 2 diabetes.
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ISSN:1521-6616
1521-7035
1365-2567
DOI:10.1016/j.clim.2005.07.008