Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success

The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent advances in understanding and overcoming hurdles to direct neuronal conversion have provided new insights into mechanisms that maintain cell ide...

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Vydáno v:Cell stem cell Ročník 21; číslo 1; s. 18
Hlavní autoři: Gascón, Sergio, Masserdotti, Giacomo, Russo, Gianluca Luigi, Götz, Magdalena
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 06.07.2017
Témata:
Animals
Cellular Reprogramming
Cellular Reprogramming Techniques - methods
Humans
Neurons - cytology
Neurons - metabolism
stem cells
brain repair
direct reprogramming
iPSC
neurogenesis
neuron
transdifferentiation
metabolism
conversion
ISSN:1875-9777, 1875-9777
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Shrnutí:The ability to directly reprogram mature cells to alternative fates challenges concepts of how cell identities are maintained, erased, and acquired. Recent advances in understanding and overcoming hurdles to direct neuronal conversion have provided new insights into mechanisms that maintain cell identity programs and have enabled high efficiency reprogramming in vivo. We discuss key cell-intrinsic molecular and metabolic constraints that influence the establishment of a new identity as well as environmental inputs from injured brains that favor or harm the conversion process. Finally, we outline the challenges ahead with a particular focus on direct neuronal reprogramming in vivo.
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ISSN:1875-9777
1875-9777
DOI:10.1016/j.stem.2017.06.011