Increased IFN-γ production by NK and CD3+/CD56+ cells in sexually HIV-1-exposed but uninfected individuals

The mechanisms involved in controlling the establishment of HIV-1 infection are not fully understood. In particular, the role of innate immunity in natural resistance exhibited by individuals who are continuously exposed to HIV-1 but remain seronegative (ESN) has not been thoroughly evaluated. We de...

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Veröffentlicht in:Clinical Immunology Jg. 120; H. 2; S. 138 - 146
Hauptverfasser: Montoya, Carlos Julio, Velilla, Paula Andrea, Chougnet, Claire, Landay, Alan L., Rugeles, Maria Teresa
Format: Journal Article
Sprache:Englisch
Veröffentlicht: San Diego, CA Elsevier Inc 01.08.2006
Elsevier
Schlagworte:
Adult
Antigens, CD - blood
Antigens, Differentiation, T-Lymphocyte - blood
B7-2 Antigen - blood
Biological and medical sciences
CD3 Complex - biosynthesis
CD3+/CD56+ cells
CD56 Antigen - biosynthesis
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
HIV Infections - immunology
HIV Seronegativity - immunology
HIV-1
HIV-1 - immunology
HIV-1-exposed seronegatives
Human immunodeficiency virus 1
Humans
IFN-γ
Immunity
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Immunophenotyping
Innate immunity
Interferon-gamma - biosynthesis
Invariant NKT cells
Killer Cells, Natural - immunology
Lectins, C-Type
Male
Medical sciences
Middle Aged
NK cells
Up-Regulation
HIV-1
CD3+/CD56+ cells
Invariant NKT cells
NK cells
IFN-γ
HIV-1-exposed seronegatives
Innate immunity
Human
Immunopathology
Invariant
Natural killer T cell
HIV-1 virus
Retroviridae
Natural immunity
AIDS
Immune deficiency
Lentivirus
Infection
Virus
Natural killer cell
Immunology
Viral disease
Human immunodeficiency virus
Gamma interferon
ISSN:1521-6616, 1521-7035, 1365-2567
Online-Zugang:Volltext
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Zusammenfassung:The mechanisms involved in controlling the establishment of HIV-1 infection are not fully understood. In particular, the role of innate immunity in natural resistance exhibited by individuals who are continuously exposed to HIV-1 but remain seronegative (ESN) has not been thoroughly evaluated. We determined the frequency and function of peripheral blood innate immune cells (plasmacytoid and myeloid dendritic cells, monocytes, NK cells, CD3+/CD56+ cells and invariant NKT cells) in ESN, chronically HIV-1-infected and low-risk HIV-1 seronegative individuals. ESN demonstrated a similar frequency of innate immune cells in comparison to controls and a higher frequency of dendritic cells, NK and invariant NKT cells compared to HIV-1-infected subjects. Incubation of mononuclear cells with stimulatory CpG ODN induced CD86 and CD69 up-regulation to a similar degree on innate cells from the three study groups. CpG ODN-stimulated secretion of cytokines was also similar between ESN and controls, while secretion of IFN-α was significantly decreased in HIV-1+ individuals. Importantly, expression of IFN-γ by PMA/Ionomycin-activated CD56bright NK cells and CD3+/CD56+ cells was significantly higher in ESN when compared with controls. The anti-viral effects of IFN-γ are well established, and so our results suggest that IFN-γ production by innate immune cells might be one of the multiple factors involved in controlling the establishment of sexually transmitted HIV-1 infection.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1521-6616
1521-7035
1365-2567
DOI:10.1016/j.clim.2006.02.008