Ethnicity and prognosis following a cardiovascular event in people with and without type 2 diabetes: Observational analysis in over 5 million subjects in England

To quantify ethnic differences in the risk of all–cause mortality and cardiovascular disease (CVD) events following a first CVD event in people with and without type 2 diabetes. We identified 5,349,271 subjects with a first CVD between 1 January 2002 and 31 May 2020 in England; CVD included aortic a...

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Veröffentlicht in:Diabetes research and clinical practice Jg. 189; S. 109967
Hauptverfasser: Remsing, Sandra C., Abner, Sophia C., Reeves, Katharine, Coles, Briana, Lawson, Claire, Gillies, Clare, Razieh, Cameron, Yates, Tom, Davies, Melanie J., Lilford, Richard, Khunti, Kamlesh, Zaccardi, Francesco
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Ireland Elsevier B.V 01.07.2022
Schlagworte:
Cardiovascular disease
Cardiovascular Diseases - etiology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
England - epidemiology
Ethnicity
Female
Humans
Mortality
Myocardial Infarction
Prognosis
Recurrent event
Risk Factors
Type 2 diabetes
England
Type 2 diabetes
Cardiovascular disease
Ethnicity
Prognosis
Recurrent event
Mortality
ISSN:0168-8227, 1872-8227, 1872-8227
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Zusammenfassung:To quantify ethnic differences in the risk of all–cause mortality and cardiovascular disease (CVD) events following a first CVD event in people with and without type 2 diabetes. We identified 5,349,271 subjects with a first CVD between 1 January 2002 and 31 May 2020 in England; CVD included aortic aneurism, cerebrovascular accident, heart failure, myocardial infarction, peripheral vascular disease, and other cardiovascular diseases. We estimated adjusted hazard ratios (HRs) for type 2 diabetes and ethnicity of three outcomes: fatal and nonfatal second CVD event (different phenotype compared to the first) and all–cause mortality. Relative to White, HRs indicated lower rates in all ethnicities and for all outcomes in both men (from 0.64 to 0.79 for all–cause death; 0.78–0.79 for CVD–related death; and 0.85–0.98 for a second CVD event) and women (0.69–0.77; 0.77–0.83; 0.83–0.95, respectively). Irrespective of ethnicity and sex, type 2 diabetes increased rates of all outcomes by around a third. Prognosis following a CVD event was consistently worse in subjects with type 2 diabetes while varied across ethnicities, suggesting the implementation of different strategies for the secondary prevention of CVD in different ethnic groups.
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ISSN:0168-8227
1872-8227
1872-8227
DOI:10.1016/j.diabres.2022.109967