Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State

Direct lineage reprogramming, including with small molecules, has emerged as a promising approach for generating desired cell types. We recently found that during chemical induction of induced pluripotent stem cells (iPSCs) from mouse fibroblasts, cells pass through an extra-embryonic endoderm (XEN)...

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Vydané v:	Cell stem cell Ročník 21; číslo 2; s. 264
Hlavní autori:	Li, Xiang, Liu, Defang, Ma, Yantao, Du, Xiaomin, Jing, Junzhan, Wang, Lipeng, Xie, Bingqing, Sun, Da, Sun, Shaoqiang, Jin, Xueqin, Zhang, Xu, Zhao, Ting, Guan, Jingyang, Yi, Zexuan, Lai, Weifeng, Zheng, Ping, Huang, Zhuo, Chang, Yanzhong, Chai, Zhen, Xu, Jun, Deng, Hongkui
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 03.08.2017
Predmet:	Aging Animals Animals, Newborn Brain - cytology Cell Differentiation Cell Lineage Cell Survival Cells, Cultured Cellular Reprogramming Endoderm - cytology Extraembryonic Membranes - cytology Female Fibroblasts - metabolism Gene Expression Profiling Genomic Instability Green Fluorescent Proteins - metabolism Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Male Mice Neurons - cytology Neurons - metabolism Neurons - transplantation Transcription, Genetic long-term expansion chemical reprogramming chemically-induced XEN-like state functional neurons direct reprogramming multifunctional XEN-like state functional hepatocyte lineage reprogramming expandable XEN-like state neural reprogramming
ISSN:	1875-9777, 1875-9777
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