Dissecting modular synthases through inhibition: A complementary chemical and genetic approach

[Display omitted] Modular synthases, such as fatty acid, polyketide, and non-ribosomal peptide synthases (NRPSs), are sophisticated machineries essential in both primary and secondary metabolism. Various techniques have been developed to understand their genetic background and enzymatic abilities. H...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry letters Vol. 30; no. 2; p. 126820
Main Authors:	Vickery, Christopher R., McCulloch, Ian P., Sonnenschein, Eva C., Beld, Joris, Noel, Joseph P., Burkart, Michael D.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15.01.2020
Subjects:	Bacterial Proteins - metabolism BpsA Domain-specific inhibitors Indigoidine Natural products Non-ribosomal peptide synthetase Peptide Synthases - chemistry Transferases (Other Substituted Phosphate Groups) - metabolism Domain-specific inhibitors BpsA Non-ribosomal peptide synthetase Natural products Indigoidine
ISSN:	0960-894X, 1464-3405, 1464-3405
Online Access:	Get full text
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