Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis
Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs). To identify the relationship between SELs and PRLs in MS, and their association with disability. 61 people with MS (pwMS) followed retrospectively wi...
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| Vydané v: | Multiple sclerosis Ročník 29; číslo 3; s. 352 |
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| Hlavní autori: | , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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01.03.2023
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| ISSN: | 1477-0970, 1477-0970 |
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| Abstract | Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).
To identify the relationship between SELs and PRLs in MS, and their association with disability.
61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs.
The median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%,
= 0.027). PRL counts positively correlated with SEL counts (ρ= 0.28,
= 0.03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0.15/year, 95% confidence interval (0.04, 0.27),
= 0.009) than SEL+PRL-patients.
SELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression. |
|---|---|
| AbstractList | Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).BACKGROUNDMagnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).To identify the relationship between SELs and PRLs in MS, and their association with disability.OBJECTIVESTo identify the relationship between SELs and PRLs in MS, and their association with disability.61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs.METHODS61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs.The median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%, p = 0.027). PRL counts positively correlated with SEL counts (ρ= 0.28, p = 0.03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0.15/year, 95% confidence interval (0.04, 0.27), p = 0.009) than SEL+PRL-patients.RESULTSThe median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%, p = 0.027). PRL counts positively correlated with SEL counts (ρ= 0.28, p = 0.03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0.15/year, 95% confidence interval (0.04, 0.27), p = 0.009) than SEL+PRL-patients.SELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression.CONCLUSIONSELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression. Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs). To identify the relationship between SELs and PRLs in MS, and their association with disability. 61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs. The median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were classified as SELs, and 80 as PRLs. 92% of patients had ⩾ 1 SEL, 56% had ⩾ 1 PRL, while both were found in 51%. SELs compared to non-SELs were more likely to also be PRLs (7% vs. 4%, = 0.027). PRL counts positively correlated with SEL counts (ρ= 0.28, = 0.03). SEL + PRL + patients had greater increases in EDSS over time (beta = 0.15/year, 95% confidence interval (0.04, 0.27), = 0.009) than SEL+PRL-patients. SELs are more numerous than PRLs in pwMS. Compared with either SELs or PRLs found in isolation, their joint occurrence was associated with greater clinical progression. |
| Author | Calvi, Alberto Ciccarelli, Olga Sastre-Garriga, Jaume Rovira, Alex Alberich, Manel Chard, Declan Tur, Carmen Rodríguez Barranco, Marta Barkhof, Frederik Pareto, Deborah Clarke, Margareta A Prados, Ferran |
| Author_xml | – sequence: 1 givenname: Alberto orcidid: 0000-0002-1953-2803 surname: Calvi fullname: Calvi, Alberto organization: Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK – sequence: 2 givenname: Margareta A orcidid: 0000-0001-5531-796X surname: Clarke fullname: Clarke, Margareta A organization: Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 3 givenname: Ferran surname: Prados fullname: Prados, Ferran organization: Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London UK/Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK/e-Health Centre, Universitat Oberta de Catalunya, Barcelona, Spain – sequence: 4 givenname: Declan orcidid: 0000-0003-3076-2682 surname: Chard fullname: Chard, Declan organization: Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK/Biomedical Research Centre, National Institute for Health Research (NIHR) and University College London Hospitals (UCLH), London, UK – sequence: 5 givenname: Olga surname: Ciccarelli fullname: Ciccarelli, Olga organization: Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK/Biomedical Research Centre, National Institute for Health Research (NIHR) and University College London Hospitals (UCLH), London, UK – sequence: 6 givenname: Manel surname: Alberich fullname: Alberich, Manel organization: Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 7 givenname: Deborah surname: Pareto fullname: Pareto, Deborah organization: Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 8 givenname: Marta surname: Rodríguez Barranco fullname: Rodríguez Barranco, Marta organization: Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (CEMCAT), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain – sequence: 9 givenname: Jaume orcidid: 0000-0002-1589-2254 surname: Sastre-Garriga fullname: Sastre-Garriga, Jaume organization: Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (CEMCAT), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain – sequence: 10 givenname: Carmen orcidid: 0000-0003-1849-3184 surname: Tur fullname: Tur, Carmen organization: Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK/Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (CEMCAT), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain – sequence: 11 givenname: Alex orcidid: 0000-0002-2132-6750 surname: Rovira fullname: Rovira, Alex organization: Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain – sequence: 12 givenname: Frederik surname: Barkhof fullname: Barkhof, Frederik organization: Queen Square MS Centre, Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, UK/Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK Biomedical Research Centre, National Institute for Health Research (NIHR) and University College London Hospitals (UCLH), London, UK/Radiology & Nuclear medicine, VU University Medical Centre, Amsterdam, The Netherlands |
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| Keywords | susceptibility-weighted imaging (SWI) Chronic active lesions volumetric MRI paramagnetic rim lesions (PRLs) multiple sclerosis slowly expanding lesions (SELs) |
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| Snippet | Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).
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| Title | Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis |
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