Phospholipid-protein balance in affective disorders: Analysis of human blood serum using Raman and FTIR spectroscopy. A pilot study

[Display omitted] •The Raman and FTIR spectra of blood serum from depressed subjects show a decrease in the amount of phospholipids and proteins.•The phospholipid–protein balance plays an important role in the development of depression.•Raman and FTIR spectroscopy could be effective tools to identif...

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Vydáno v:Journal of pharmaceutical and biomedical analysis Ročník 131; s. 287 - 296
Hlavní autoři: Depciuch, Joanna, Sowa-Kućma, Magdalena, Nowak, Gabriel, Dudek, Dominika, Siwek, Marcin, Styczeń, Krzysztof, Parlińska-Wojtan, Magdalena
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier B.V 30.11.2016
Témata:
Adult
Affective disorders
Aged
Aging - blood
Bipolar Disorder - blood
Blood Proteins - analysis
Case-Control Studies
Depression
Depressive Disorder, Major - blood
Female
FTIR
Humans
Male
Middle Aged
Phospholipid – protein balance
Phospholipids - blood
Pilot Projects
Raman spectroscopy
Serum markers
Sex Characteristics
Spectroscopy, Fourier Transform Infrared
Spectrum Analysis, Raman
Young Adult
Serum markers
Phospholipid – protein balance
Depression
Affective disorders
Raman spectroscopy
FTIR
ISSN:0731-7085, 1873-264X
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Shrnutí:[Display omitted] •The Raman and FTIR spectra of blood serum from depressed subjects show a decrease in the amount of phospholipids and proteins.•The phospholipid–protein balance plays an important role in the development of depression.•Raman and FTIR spectroscopy could be effective tools to identify the changes in the blood serum during depression. Raman and FTIR (Fourier Transform Infra Red) spectroscopies provide information on the chemical structure of compounds through identification and analysis of functional groups. In the present study, both spectroscopic techniques were used for investigating the phospholipid – protein balance in blood serum of depressed subjects (major depressive disorder and bipolar disorder type I or II) taking also into account their age and gender. The obtained results were compared with those of healthy subjects. The Raman and FTIR (using ATR (Attenuated Total Reflectance) technique), spectra show that a correlation between the level of phospholipids and proteins exists. Indeed, in depressed subjects the quantity of phospholipids and proteins is lower, compared to healthy ones. The second derivative of FTIR spectra shows that phospholipids directly affect the structure of proteins and their functions. In all male depressed subjects a higher amount of phospholipids and proteins compared to female depressed subjects was measured, offering them faster recovery perspectives. Spectroscopy results show that the phospholipids’ and proteins’ levels are lower in depressed subjects from 41 to 65 compared to the age group between 20 and 40, independently from the gender. Consequently, this study shows that Raman and infrared spectroscopies might be applied as a diagnostic tool to evaluate the balance between phospholipids and proteins in blood serum as a potential biomarker in depressive disorders.
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ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2016.08.037