Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme are insensitive to the apoptotic effect of TRAIL. Improvement in therapeutic modalities that enhances the efficacy of TRAIL in glioma is muc...

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Bibliographic Details
Published in:	Stem cells and development Vol. 22; no. 13; p. 1870
Main Authors:	Yulyana, Yulyana, Endaya, Berwini B, Ng, Wai H, Guo, Chang M, Hui, Kam M, Lam, Paula Y P, Ho, Ivy A W
Format:	Journal Article
Language:	English
Published:	United States 01.07.2013
Subjects:	Animals Apoptosis - drug effects Brain Neoplasms - genetics Brain Neoplasms - therapy Carbenoxolone - pharmacology Cell Line, Tumor Connexin 43 Gap Junctions - metabolism Gene Expression Regulation, Neoplastic Glioma - genetics Glioma - pathology Glioma - therapy Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Simplexvirus - genetics TNF-Related Apoptosis-Inducing Ligand - biosynthesis TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Up-Regulation Xenograft Model Antitumor Assays
ISSN:	1557-8534, 1557-8534
Online Access:	Get more information
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