Carbenoxolone enhances TRAIL-induced apoptosis through the upregulation of death receptor 5 and inhibition of gap junction intercellular communication in human glioma

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been used extensively in cancer therapy. However, more than half of glioblastoma multiforme are insensitive to the apoptotic effect of TRAIL. Improvement in therapeutic modalities that enhances the efficacy of TRAIL in glioma is muc...

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Vydáno v:	Stem cells and development Ročník 22; číslo 13; s. 1870
Hlavní autoři:	Yulyana, Yulyana, Endaya, Berwini B, Ng, Wai H, Guo, Chang M, Hui, Kam M, Lam, Paula Y P, Ho, Ivy A W
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2013
Témata:	Animals Apoptosis - drug effects Brain Neoplasms - genetics Brain Neoplasms - therapy Carbenoxolone - pharmacology Cell Line, Tumor Connexin 43 Gap Junctions - metabolism Gene Expression Regulation, Neoplastic Glioma - genetics Glioma - pathology Glioma - therapy Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Simplexvirus - genetics TNF-Related Apoptosis-Inducing Ligand - biosynthesis TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Up-Regulation Xenograft Model Antitumor Assays
ISSN:	1557-8534, 1557-8534
On-line přístup:	Zjistit podrobnosti o přístupu
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