Longitudinal up‐regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment
Objective/Hypothesis Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the...
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| Vydáno v: | Laryngoscope Investigative Otolaryngology Ročník 2; číslo 6; s. 344 - 350 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
John Wiley & Sons, Inc
01.12.2017
John Wiley and Sons Inc |
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| ISSN: | 2378-8038, 0023-852X, 2378-8038 |
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| Abstract | Objective/Hypothesis
Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.
Study Design
Prospective, single‐arm repeated measures
Methods
Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.
Results
The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.
Conclusion
EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.
Level of Evidence
2b. |
|---|---|
| AbstractList | Objective/HypothesisMeniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Study DesignProspective, single‐arm repeated measuresMethodsEleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.ResultsThe frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.ConclusionEH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.Level of Evidence2b. Objective/Hypothesis Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design Prospective, single‐arm repeated measures Methods Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. Results The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. Conclusion EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. Level of Evidence 2b. Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Objective/HypothesisMeniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Prospective, single-arm repeated measures.Study DesignProspective, single-arm repeated measures.Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.MethodsEleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.ResultsThe frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.ConclusionEH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.2b.Level of Evidence2b. Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Prospective, single-arm repeated measures. Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. 2b. |
| Author | Akahani, Shiro Oya, Ryohei Takeda, Noriaki Fukushima, Munehisa Naganawa, Shinji Inohara, Hidenori Kitahara, Tadashi |
| AuthorAffiliation | 4 Department of Radiology Nagoya University Graduate School of Medicine Aichi Japan 1 Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan 2 Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan 3 Department of Otolaryngology and Head and Neck Surgery Nara Medical University Nara Japan 5 Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan |
| AuthorAffiliation_xml | – name: 5 Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan – name: 3 Department of Otolaryngology and Head and Neck Surgery Nara Medical University Nara Japan – name: 2 Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan – name: 4 Department of Radiology Nagoya University Graduate School of Medicine Aichi Japan – name: 1 Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan |
| Author_xml | – sequence: 1 givenname: Munehisa orcidid: 0000-0001-9785-8166 surname: Fukushima fullname: Fukushima, Munehisa email: mfukushima@kansaih.johas.go.jp organization: Osaka University, Graduate School of Medicine – sequence: 2 givenname: Tadashi surname: Kitahara fullname: Kitahara, Tadashi organization: Nara Medical University – sequence: 3 givenname: Ryohei surname: Oya fullname: Oya, Ryohei organization: Osaka University, Graduate School of Medicine – sequence: 4 givenname: Shiro surname: Akahani fullname: Akahani, Shiro organization: Kansai Rosai Hospital – sequence: 5 givenname: Hidenori surname: Inohara fullname: Inohara, Hidenori organization: Osaka University, Graduate School of Medicine – sequence: 6 givenname: Shinji surname: Naganawa fullname: Naganawa, Shinji organization: Nagoya University Graduate School of Medicine – sequence: 7 givenname: Noriaki surname: Takeda fullname: Takeda, Noriaki organization: University of Tokushima School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29299506$$D View this record in MEDLINE/PubMed |
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| Copyright | 2017 The Authors Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society 2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | Meniere's disease endolymphatic hydrops gadolinium‐enhanced inner ear magnetic resonance imaging |
| Language | English |
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| Notes | Financial disclosure: This research was supported in part by a Grant‐in‐Aid for Research on Intractable Vestibular Disorder from Japan AMED (2015‐2017) and by research funds to promote the hospital functions of Japan Organization of Occupational Health and Safety. The authors have no other funding, financial relationships, or conflicts to disclose. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| References | 2004; 66 2007; 19 2010; 15 1938; 44 1995; 519 2007; 264 2013; 40 1985; 6 2011; 32 1995; 113 2014; 271 2005; 26 2012; 11 2012; 33 1938; 31 2009; 30 1989; 98 2007; 117 2000; 544 2013; 12 2013; 34 1986; 48 1982; 44 2013; 133 2010; 130 2000; 140 2014; 35 2017 2016; 136 2003; 82 2012; 7 2013; 270 2016; 130 2014; 32 |
| References_xml | – start-page: 1 year: 2017 end-page: 5 article-title: Contralateral type of delayed endolymphatic hydrops may consist of two phenotypes based on a magnetic resonance imaging preliminary study publication-title: Acta Otolaryngol – volume: 19 start-page: 901 year: 2007 end-page: 906 article-title: The relevance of an elevation in the plasma vasopressin levels to the pathogenesis of Meniere's attack publication-title: J Neuroendocrinol – volume: 35 start-page: e162 year: 2014 end-page: 169 article-title: Prevalence, associated factors, and comorbid conditions for Meniere's disease publication-title: Ear Hear – volume: 31 start-page: 1317 year: 1938 end-page: 1336 article-title: Observations on the pathology of Meniere's syndrome: (Section of Otology) publication-title: Proc R Soc Med – volume: 66 start-page: 291 year: 2004 end-page: 296 article-title: Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs publication-title: ORL J Otorhinolaryngol Relat Spec – volume: 130 start-page: 242 year: 2016 end-page: 247 article-title: Does the intravenous administration of frusemide reduce endolymphatic hydrops? publication-title: The J Laryngol Otol – volume: 34 start-page: 1210 year: 2013 end-page: 1214 article-title: Endolymphatic hydrops in Meniere's disease: cause, consequence, or epiphenomenon? publication-title: Otol Neurotol – volume: 136 start-page: 1304 year: 2016 end-page: 1308 article-title: Preceding profound deafness and co‐factors promote development of endolymphatic hydrops in preliminary patients with delayed endolymphatic hydrops publication-title: Acta Otolaryngol – volume: 264 start-page: 1275 year: 2007 end-page: 1281 article-title: Glycerol pure tone audiometry and glycerol vestibular evoked myogenic potential: representing specific status of endolymphatic hydrops in the inner ear publication-title: Eur Arch Otorhinolaryngol – volume: 44 start-page: 2310 year: 1938 end-page: 2312 article-title: Uber die pathologische Veranderung bei einem Meniere‐Kraken publication-title: J Otolaryngol Jpn – volume: 271 start-page: 887 year: 2014 end-page: 897 article-title: Meta‐analysis of clinical studies with betahistine in Meniere's disease and vestibular vertigo publication-title: Eur Arch Otorhinolaryngol – volume: 113 start-page: 181 year: 1995 end-page: 185 article-title: American Academy of Otolaryngology–Head and Neck Foundation, Inc publication-title: Otolaryngol Head Neck Surg – volume: 12 start-page: 63 year: 2013 end-page: 68 article-title: Imaging of Meniere's disease after intravenous administration of single‐dose gadodiamide: utility of multiplication of MR cisternography and HYDROPS image publication-title: Magn Reson Med Sci – volume: 26 start-page: 74 year: 2005 end-page: 81 article-title: Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? publication-title: Otol Neurotol – volume: 519 start-page: 219 year: 1995 end-page: 222 article-title: Antidiuretic hormone (ADH) and endolymphatic hydrops publication-title: Acta Otolaryngol Suppl – volume: 82 start-page: 185 year: 2003 end-page: 187 article-title: Changing trends in the surgical treatment of Meniere's disease: results of a 10‐year survey publication-title: Ear Nose Throat J – volume: 7 start-page: e39086 year: 2012 article-title: Betahistine exerts a dose‐dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo publication-title: PloS One – volume: 133 start-page: 924 year: 2013 end-page: 929 article-title: Changes in endolymphatic hydrops after sac surgery examined by Gd‐enhanced MRI publication-title: Acta Otolaryngol – volume: 44 start-page: 232 year: 1982 end-page: 238 article-title: Treatment of Meniere's disease with isosorbide publication-title: ORL J Otorhinolaryngol Relat Spec – volume: 136 start-page: 451 year: 2016 end-page: 455 article-title: Gadolinium‐enhanced inner ear magnetic resonance imaging for evaluation of delayed endolymphatic hydrops, including a bilateral case publication-title: Acta Otolaryngol – volume: 30 start-page: 812 year: 2009 end-page: 819 article-title: Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops publication-title: Otol Neurotol – volume: 26 start-page: 778 year: 2005 end-page: 781 article-title: Volume of components of labyrinth: magnetic resonance imaging study publication-title: Otol Neurot – volume: 40 start-page: 425 year: 2013 end-page: 430 article-title: Long‐term results of endolymphatic sac drainage with local steroids for intractable Meniere's disease publication-title: Auris Nasus Larynx – volume: 6 start-page: 358 year: 1985 end-page: 367 article-title: Gentamicin tympanoclysis: effects on the vestibular secretory cells publication-title: Am J Otolaryngol – volume: 544 start-page: 34 year: 2000 end-page: 39 article-title: A review of medical treatment for Meniere's disease publication-title: Acta Otolaryngol Suppl – volume: 117 start-page: 415 year: 2007 end-page: 420 article-title: Visualization of endolymphatic hydrops in patients with Meniere's disease publication-title: Laryngoscope – volume: 32 start-page: 191 year: 2014 end-page: 204 article-title: Visualization of endolymphatic hydrops with MR imaging in patients with Meniere's disease and related pathologies: current status of its methods and clinical significance publication-title: Jpn J Radiol – volume: 32 start-page: 1152 year: 2011 end-page: 1157 article-title: Progression of endolymphatic hydrops in Meniere's disease as evaluated by magnetic resonance imaging publication-title: Otol Neurotol – volume: 98 start-page: 873 year: 1989 end-page: 883 article-title: Meniere's syndrome and endolymphatic hydrops. Double‐blind temporal bone study publication-title: Ann Otol Rhinol Laryngol – volume: 48 start-page: 287 year: 1986 end-page: 292 article-title: Use of a diuretic (Dyazide) in the treatment of Meniere's disease. A double‐blind cross‐over placebo‐controlled study publication-title: ORL J Otorhinolaryngol Relat Spec – volume: 33 start-page: 629 year: 2012 end-page: 633 article-title: Magnetic resonance imaging fails to show evidence of reduced endolymphatic hydrops in gentamicin treatment of Meniere's disease publication-title: Otol Neurotol – volume: 15 start-page: 318 year: 2010 end-page: 322 article-title: Current‐day prevalence of Meniere's syndrome publication-title: Audiol Neurotol – volume: 130 start-page: 644 year: 2010 end-page: 651 article-title: Long‐term course of Meniere's disease revisited publication-title: Acta Otolaryngol – volume: 270 start-page: 1231 year: 2013 end-page: 1235 article-title: Effect of standard‐dose Betahistine on endolymphatic hydrops: an MRI pilot study publication-title: Eur Arch Otorhinolaryngol – volume: 140 start-page: 1 year: 2000 end-page: 6 article-title: Endolymphatic hydrops induced by chronic administration of vasopressin publication-title: Hear Res – volume: 11 start-page: 213 year: 2012 end-page: 219 article-title: Imaging of Meniere's disease after intravenous administration of single‐dose gadodiamide: utility of subtraction images with different inversion time publication-title: Magn Reson Med Sci |
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Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss,... Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its... Objective/HypothesisMeniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss,... |
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| StartPage | 344 |
| SubjectTerms | endolymphatic hydrops gadolinium‐enhanced inner ear magnetic resonance imaging Glycerol Homeostasis Hypotheses Medical treatment Meniere disease Meniere's disease Otology Otology, Neurotology, and Neuroscience Patients Vertigo |
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| Title | Longitudinal up‐regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment |
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