Longitudinal up‐regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment
Objective/Hypothesis Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the...
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| Vydané v: | Laryngoscope Investigative Otolaryngology Ročník 2; číslo 6; s. 344 - 350 |
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| Hlavní autori: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
John Wiley & Sons, Inc
01.12.2017
John Wiley and Sons Inc |
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| ISSN: | 2378-8038, 0023-852X, 2378-8038 |
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| Abstract | Objective/Hypothesis
Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.
Study Design
Prospective, single‐arm repeated measures
Methods
Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.
Results
The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.
Conclusion
EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.
Level of Evidence
2b. |
|---|---|
| AbstractList | Objective/HypothesisMeniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Study DesignProspective, single‐arm repeated measuresMethodsEleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.ResultsThe frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.ConclusionEH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.Level of Evidence2b. Objective/Hypothesis Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design Prospective, single‐arm repeated measures Methods Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium‐enhanced inner ear magnetic resonance (MR) imaging and neuro‐otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. Results The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13–91% of the pre‐treatment level. The volume ratio of post‐treatment EH‐to‐pre‐treatment EH ranged from 1.01–3.22. The total volume of pre‐treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. Conclusion EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. Level of Evidence 2b. Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Objective/HypothesisMeniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Prospective, single-arm repeated measures.Study DesignProspective, single-arm repeated measures.Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.MethodsEleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.ResultsThe frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.ConclusionEH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.2b.Level of Evidence2b. Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Prospective, single-arm repeated measures. Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. 2b. |
| Author | Akahani, Shiro Oya, Ryohei Takeda, Noriaki Fukushima, Munehisa Naganawa, Shinji Inohara, Hidenori Kitahara, Tadashi |
| AuthorAffiliation | 4 Department of Radiology Nagoya University Graduate School of Medicine Aichi Japan 1 Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan 2 Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan 3 Department of Otolaryngology and Head and Neck Surgery Nara Medical University Nara Japan 5 Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan |
| AuthorAffiliation_xml | – name: 5 Department of Otolaryngology University of Tokushima School of Medicine Tokushima Japan – name: 3 Department of Otolaryngology and Head and Neck Surgery Nara Medical University Nara Japan – name: 2 Department of Otolaryngology and Head and Neck Surgery Osaka University, Graduate School of Medicine Osaka Japan – name: 4 Department of Radiology Nagoya University Graduate School of Medicine Aichi Japan – name: 1 Department of Otolaryngology and Head and Neck Surgery Kansai Rosai Hospital Hyogo Japan |
| Author_xml | – sequence: 1 givenname: Munehisa orcidid: 0000-0001-9785-8166 surname: Fukushima fullname: Fukushima, Munehisa email: mfukushima@kansaih.johas.go.jp organization: Osaka University, Graduate School of Medicine – sequence: 2 givenname: Tadashi surname: Kitahara fullname: Kitahara, Tadashi organization: Nara Medical University – sequence: 3 givenname: Ryohei surname: Oya fullname: Oya, Ryohei organization: Osaka University, Graduate School of Medicine – sequence: 4 givenname: Shiro surname: Akahani fullname: Akahani, Shiro organization: Kansai Rosai Hospital – sequence: 5 givenname: Hidenori surname: Inohara fullname: Inohara, Hidenori organization: Osaka University, Graduate School of Medicine – sequence: 6 givenname: Shinji surname: Naganawa fullname: Naganawa, Shinji organization: Nagoya University Graduate School of Medicine – sequence: 7 givenname: Noriaki surname: Takeda fullname: Takeda, Noriaki organization: University of Tokushima School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29299506$$D View this record in MEDLINE/PubMed |
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| Copyright | 2017 The Authors Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society 2017. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | Meniere's disease endolymphatic hydrops gadolinium‐enhanced inner ear magnetic resonance imaging |
| Language | English |
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| Notes | Financial disclosure: This research was supported in part by a Grant‐in‐Aid for Research on Intractable Vestibular Disorder from Japan AMED (2015‐2017) and by research funds to promote the hospital functions of Japan Organization of Occupational Health and Safety. The authors have no other funding, financial relationships, or conflicts to disclose. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| References | 2004; 66 2007; 19 2010; 15 1938; 44 1995; 519 2007; 264 2013; 40 1985; 6 2011; 32 1995; 113 2014; 271 2005; 26 2012; 11 2012; 33 1938; 31 2009; 30 1989; 98 2007; 117 2000; 544 2013; 12 2013; 34 1986; 48 1982; 44 2013; 133 2010; 130 2000; 140 2014; 35 2017 2016; 136 2003; 82 2012; 7 2013; 270 2016; 130 2014; 32 |
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Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss,... Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its... Objective/HypothesisMeniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss,... |
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| SubjectTerms | endolymphatic hydrops gadolinium‐enhanced inner ear magnetic resonance imaging Glycerol Homeostasis Hypotheses Medical treatment Meniere disease Meniere's disease Otology Otology, Neurotology, and Neuroscience Patients Vertigo |
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| Title | Longitudinal up‐regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment |
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