Abdominal Visceral Adipose Tissue and All-Cause Mortality: A Systematic Review

Increased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk. We systematically searched four databases. We performed citations/articles screening, data abstraction, and quality ass...

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Vydáno v:Frontiers in endocrinology (Lausanne) Ročník 13; s. 922931
Hlavní autoři: Saad, Randa K., Ghezzawi, Malak, Horanieh, Renee, Khamis, Assem M., Saunders, Katherine H., Batsis, John A., Chakhtoura, Marlene
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 22.08.2022
Témata:
Abdominal Fat
abdominal visceral fat
Aged
all-cause mortality
Body Mass Index
Endocrinology
fatal outcome
Humans
Intra-Abdominal Fat - diagnostic imaging
Intra-Abdominal Fat - metabolism
Risk Factors
systematic review
Tomography, X-Ray Computed
visceral adipose tissue
abdominal visceral fat
systematic review
all-cause mortality
fatal outcome
visceral adipose tissue
ISSN:1664-2392, 1664-2392
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Shrnutí:Increased abdominal visceral adipose tissue (VAT) implies an adverse cardio-metabolic profile. We examined the association of abdominal VAT parameters and all-cause mortality risk. We systematically searched four databases. We performed citations/articles screening, data abstraction, and quality assessment in duplicate and independently (CRD42020205021). We included 12 cohorts, the majority used computed tomography to assess abdominal VAT area. Six cohorts with a mean age ≤ 65 years, examining all-cause mortality risk per increment in VAT area (cm ) or volume (cm ), showed a 11-98% relative risk increase with higher VAT parameters. However, the association lost significance after adjusting for glycemic indices, body mass index, or other fat parameters. In 4 cohorts with a mean age >65 years, the findings on mortality were inconsistent. Conversely, in two cohorts (mean age 73-77 years), a higher VAT density, was inversely proportional to VAT area, and implied a higher mortality risk. A high abdominal VAT area seems to be associated with increased all-cause mortality in individuals ≤ 65 years, possibly mediated by metabolic complications, and not through an independent effect. This relationship is weaker and may reverse in older individuals, most likely secondary to confounding bias and reverse causality. An individual participant data meta-analysis is needed to confirm our findings, and to define an abdominal VAT area cutoff implying increased mortality risk. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=205021, identifier CRD42020205021.
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Edited by: Yuanyuan Wang, Monash University, Australia
These authors share first authorship
This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology
Reviewed by: Kai G. Kahl, Hannover Medical School, Germany; Dagfinn Aune, Bjørknes College, Norway
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.922931