Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation

Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-ap...

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Vydáno v:Current oncology (Toronto) Ročník 28; číslo 6; s. 5041 - 5053
Hlavní autoři: Grams, Astrid Ellen, Mangesius, Stephanie, Steiger, Ruth, Radovic, Ivan, Rietzler, Andreas, Walchhofer, Lisa Maria, Galijašević, Malik, Mangesius, Julian, Nowosielski, Martha, Freyschlag, Christian Franz, Kerschbaumer, Johannes, Gizewski, Elke Ruth
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI 01.12.2021
MDPI AG
Témata:
ATP
Brain
cerebral energy metabolism
chemoradiation
Chemoradiotherapy
Female
glioblastoma
Glioblastoma - diagnostic imaging
Glioblastoma - metabolism
Glioblastoma - therapy
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
normal-appearing brain tissue
phosphorous magnetic resonance spectroscopy (31P-MRS)
glioblastoma
normal-appearing brain tissue
tumor infiltration
cerebral energy metabolism
ATP
chemoradiation
phosphorous magnetic resonance spectroscopy (31P-MRS)
ISSN:1718-7729, 1198-0052, 1718-7729
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Shrnutí:Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-appearing” brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest “contrast-enhancing (CE) tumor” (if present), “adjacent to the (former) tumor”, “ipsilateral distant” hemisphere, and “contralateral” hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to “normalize” under therapy. In different “normal-appearing” brain areas of GB patients, the energy and membrane metabolism either “normalized” or were “disturbed”, in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort.
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Contributed equally, shared first author.
ISSN:1718-7729
1198-0052
1718-7729
DOI:10.3390/curroncol28060424