Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation

Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-ap...

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Veröffentlicht in:Current oncology (Toronto) Jg. 28; H. 6; S. 5041 - 5053
Hauptverfasser: Grams, Astrid Ellen, Mangesius, Stephanie, Steiger, Ruth, Radovic, Ivan, Rietzler, Andreas, Walchhofer, Lisa Maria, Galijašević, Malik, Mangesius, Julian, Nowosielski, Martha, Freyschlag, Christian Franz, Kerschbaumer, Johannes, Gizewski, Elke Ruth
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI 01.12.2021
MDPI AG
Schlagworte:
ATP
Brain
cerebral energy metabolism
chemoradiation
Chemoradiotherapy
Female
glioblastoma
Glioblastoma - diagnostic imaging
Glioblastoma - metabolism
Glioblastoma - therapy
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
normal-appearing brain tissue
phosphorous magnetic resonance spectroscopy (31P-MRS)
glioblastoma
normal-appearing brain tissue
tumor infiltration
cerebral energy metabolism
ATP
chemoradiation
phosphorous magnetic resonance spectroscopy (31P-MRS)
ISSN:1718-7729, 1198-0052, 1718-7729
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Abstract Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-appearing” brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest “contrast-enhancing (CE) tumor” (if present), “adjacent to the (former) tumor”, “ipsilateral distant” hemisphere, and “contralateral” hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to “normalize” under therapy. In different “normal-appearing” brain areas of GB patients, the energy and membrane metabolism either “normalized” or were “disturbed”, in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort.
AbstractList Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably “normal-appearing” brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest “contrast-enhancing (CE) tumor” (if present), “adjacent to the (former) tumor”, “ipsilateral distant” hemisphere, and “contralateral” hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to “normalize” under therapy. In different “normal-appearing” brain areas of GB patients, the energy and membrane metabolism either “normalized” or were “disturbed”, in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort.
Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably "normal-appearing" brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest "contrast-enhancing (CE) tumor" (if present), "adjacent to the (former) tumor", "ipsilateral distant" hemisphere, and "contralateral" hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to "normalize" under therapy. In different "normal-appearing" brain areas of GB patients, the energy and membrane metabolism either "normalized" or were "disturbed", in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort.Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was to investigate changes in the energy and membrane metabolism measured with phosphorous MR spectroscopy (31P-MRS) in the presumably "normal-appearing" brain following chemoradiation therapy (CRT) in GB patients in comparison to healthy controls. Twenty (seven female, thirteen male) GB patients underwent a 31P-MRS scan prior to surgery (baseline) and after three months of standard CRT (follow-up examination. The regions of interest "contrast-enhancing (CE) tumor" (if present), "adjacent to the (former) tumor", "ipsilateral distant" hemisphere, and "contralateral" hemisphere were compared, differentiating between patients with stable (SD) and progressive disease (PD). Metabolite ratios PCr/ATP, Pi/ATP, PCr/Pi, PME/PDE, PME/PCr, and PDE/ATP were investigated. In PD, energy and membrane metabolism in CE tumor areas have a tendency to "normalize" under therapy. In different "normal-appearing" brain areas of GB patients, the energy and membrane metabolism either "normalized" or were "disturbed", in comparison to baseline or controls. Differences were also detected between patients with SD and PD. 31P-MRS might contribute as an additional imaging biomarker for outcome measurement, which remains to be investigated in a larger cohort.
Author Steiger, Ruth
Grams, Astrid Ellen
Radovic, Ivan
Mangesius, Julian
Nowosielski, Martha
Gizewski, Elke Ruth
Galijašević, Malik
Rietzler, Andreas
Freyschlag, Christian Franz
Kerschbaumer, Johannes
Mangesius, Stephanie
Walchhofer, Lisa Maria
AuthorAffiliation 1 Department of Neuroradiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; astrid.grams@i-med.ac.at (A.E.G.); stephanie.mangeisus@i-med.ac.at (S.M.); ivan.radovic@icloud.com (I.R.); andreas.rietzler@i-med.ac.at (A.R.); malik.galijasevic@i-med.ac.at (M.G.); elke.gizewski@i-med.ac.at (E.R.G.)
4 Department of Radiation Oncology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; julian.mangesius@i-med.ac.at
2 Neuroimaging Core Facility, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
6 Department of Neurosurgery, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; christian.freyschlag@i-med.ac.at (C.F.F.); johannes.kerschbaumer@i-med.ac.at (J.K.)
5 Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; martha.nowosielski@i-med.ac.at
3 Department of Radiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; lisa.walchhof
AuthorAffiliation_xml – name: 3 Department of Radiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; lisa.walchhofer@kh-schwaz.at
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Issue 6
Keywords glioblastoma
normal-appearing brain tissue
tumor infiltration
cerebral energy metabolism
ATP
chemoradiation
phosphorous magnetic resonance spectroscopy (31P-MRS)
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Snippet Brain parenchyma infiltration with glioblastoma (GB) cannot be entirely visualized by conventional magnetic resonance imaging (MRI). The aim of this study was...
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SubjectTerms ATP
Brain
cerebral energy metabolism
chemoradiation
Chemoradiotherapy
Female
glioblastoma
Glioblastoma - diagnostic imaging
Glioblastoma - metabolism
Glioblastoma - therapy
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
normal-appearing brain tissue
phosphorous magnetic resonance spectroscopy (31P-MRS)
Title Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation
URI https://www.ncbi.nlm.nih.gov/pubmed/34940063
https://www.proquest.com/docview/2613292172
https://pubmed.ncbi.nlm.nih.gov/PMC8700426
https://doaj.org/article/08ab38d5fdec453b825b8789ab31a0b0
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